[1]颜 波,狄镇海,施瑞华,等.新型可降解防移位食管支架实验研究[J].介入放射学杂志,2021,30(02):153-157.
 YAN Bo,DI Zhenhai,SHI Ruihua,et al.Experimental study on novel biodegradable and anti-displacement esophageal stents[J].journal interventional radiology,2021,30(02):153-157.
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新型可降解防移位食管支架实验研究()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
30
期数:
2021年02
页码:
153-157
栏目:
实验研究
出版日期:
2021-02-25

文章信息/Info

Title:
Experimental study on novel biodegradable and anti-displacement esophageal stents
作者:
颜 波 狄镇海 施瑞华 冷德嵘 吕朋华
Author(s):
YAN Bo DI Zhenhai SHI Ruihua LENG Derong LV Penghua.
Department of Interventional Radiology, Subei People’s Hospital, Yangzhou, Jiangsu Province 225001, China
关键词:
【关键词】 食道狭窄 可生物降解食管支架 动物实验
文献标志码:
A
摘要:
【摘要】 目的 通过动物实验探讨新型可降解防移位食管支架的安全性、降解性能及设计策略。 方法 采用医用聚对二氧环己酮[poly(p-dioxanone),PPDO]编制有“倒刺结”结构(实验组)和无“倒刺结”结构(对照组)的全覆膜分段式食管支架,分别植入巴马猪食管。术后每周1次胃镜检查,直至支架降解滑落。胃镜下观察支架移位、支架降解和食管黏膜增生情况。结果 实验组(n=9)、对照组(n=9)实验猪分别植入有“倒刺结”、无“倒刺结”食管支架各9枚,手术均获成功。未出现食管破裂出血、生命体征异常等并发症。术后1、2、4周两组支架移位程度评分差异有统计学意义(P<0.05)。两组支架降解和黏膜增生反应相当,每周评分差异均无统计学意义(P>0.05)。结论 新型可降解防移位食管支架植入安全,未发生严重并发症。早期(1~4周内)防移位效果显著,不影响支架降解,不增加食管黏膜增生,有一定的临床应用前景。

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备注/Memo

备注/Memo:
(收稿日期:2019- 11- 21)
(本文编辑:边 佶)
更新日期/Last Update: 2021-02-22