[1]肖丽珍,方锋凯,陈开良.超声引导下介入治疗对卵巢巧克力囊肿患者血清转录因子活化蛋白激酶B、糖类抗原125、白细胞介素-6的影响[J].介入放射学杂志,2020,29(11):1131-1135.
 XIAO Lizhen,FANG Fengkai,CHEN Kailiang..Effect of ultrasound-guided interventional therapy on serum JUNB, CA125 and IL-6 in patients with ovarian chocolate cyst[J].journal interventional radiology,2020,29(11):1131-1135.
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超声引导下介入治疗对卵巢巧克力囊肿患者血清转录因子活化蛋白激酶B、糖类抗原125、白细胞介素-6的影响()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
29
期数:
2020年11
页码:
1131-1135
栏目:
临床研究
出版日期:
2020-11-25

文章信息/Info

Title:
Effect of ultrasound-guided interventional therapy on serum JUNB, CA125 and IL-6 in patients with ovarian chocolate cyst
作者:
肖丽珍 方锋凯 陈开良
Author(s):
XIAO Lizhen FANG Fengkai CHEN Kailiang.
Department of Ultrasound Medicine, Hainan West Central Hospital, Danzhou, Hainan Province 571799, China
关键词:
【关键词】 卵巢巧克力囊肿 转录因子活化蛋白激酶B 糖类抗原125 白细胞介素-6
文献标志码:
A
摘要:
【摘要】 目的 探讨超声引导下介入治疗对卵巢巧克力囊肿患者血清转录因子活化蛋白激酶B(JUNB)、糖类抗原125(CA125)、白细胞介素-6(IL-6)的影响,为巧克力囊肿患者的预后评估提供一定的理论依据。 方法 前瞻性纳入2016年8月至2018年9月收治的96例卵巢巧克力囊肿患者为研究对象,均接受超声引导下介入治疗。在介入治疗前、治疗后6个月检测血清中JUNB、CA125、IL-6水平,同时收集患者治疗后6个月的随访信息,根据是否复发分为复发组(n=78)和未复发组(n=18),比较两组治疗前、治疗后3、6个月时血清中JUNB、CA125、IL-6的差异,并分析3个指标的变化趋势,同时运用受试者工作特征(ROC)曲线判断血清中JUNB、CA125、IL-6在评估患者预后中的价值,计算曲线下面积(AUC)、灵敏度和特异度。结果 未复发治疗后6个月时血清JUNB、CA125、IL-6均呈下降趋势(P<0.05),而复发组仅在治疗后6个月有上升趋势(P<0.05)。JUNB在治疗前、治疗后3、6个月时的AUC分别为0.490、0.661、0.922;CA125分别为0.471、0.946、0.979;IL-6分别为0.519、0.647、0.852。其最佳截断值分别为1.752、64.82、46.62。 结论 超声引导下介入治疗可降低卵巢巧克力囊肿患者血清中JUNB、CA125、IL-6的水平,复发患者以上指标均有上升趋势,血清JUNB和IL-6可在一定程度上评估患者预后。

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备注/Memo

备注/Memo:
(收稿日期:2019- 12- 10)
(本文编辑:俞瑞纲)
更新日期/Last Update: 2020-11-16