[1]吕天娇,李凌燕,张 弘,等.肾动脉主干加分支射频消融在难治性高血压治疗中的应用[J].介入放射学杂志,2020,29(09):879-882.
 Lv Tianjiao,LI Lingyan,ZHANG Hong,et al.Application of radiofrequency ablation of the main renal artery together with its branch in treating resistant hypertension[J].journal interventional radiology,2020,29(09):879-882.
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肾动脉主干加分支射频消融在难治性高血压治疗中的应用()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
29
期数:
2020年09
页码:
879-882
栏目:
心脏介入
出版日期:
2020-09-25

文章信息/Info

Title:
Application of radiofrequency ablation of the main renal artery together with its branch in treating resistant hypertension
作者:
吕天娇 李凌燕 张 弘 张 华 李清丽 邓伟明 段秋霞 郜俊清刘宗军
Author(s):
Lv Tianjiao LI Lingyan ZHANG Hong ZHANG Hua LI Qingli DENG Weiming DUAN Qiuxia GAO Junqing LIU Zongjun.
Department of Cardiology, Affiliated Putuo District Central Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
关键词:
【关键词】 肾动脉分支去神经化 难治性高血压 经皮肾交感神经射频消融术
文献标志码:
A
摘要:
【摘要】 目的 探讨肾动脉分支去神经化在经皮肾交感神经射频消融治疗难治性高血压中的应用。 方法 入选难治性高血压患者60例,完成肾动脉造影后随机分为单纯主支消融组、主支+分支消融组,各30例。观察分析患者基本资料,手术相关参数(消融点数、温度、平均能量),术前和术后2年诊室血压、动态血压等。 结果 两组患者年龄、伴发疾病、用药情况差异无统计学意义(P>0.05)。主支+分支消融组消融点数与单纯主支消融组相比呈显著增加趋势。两组患者术后诊室血压、动态血压均低于术前(P<0.05)。术后3~12个月期间主支+分支消融组诊室血压显著低于单纯主支消融组(P<0.001),但术后15~24个月期间两组差异无统计学意义(P>0.05)。 结论 肾动脉主支+分支消融术治疗难治性高血压安全有效,但远期随访中与单纯主支消融相比无明显优势。

参考文献/References:

[1] Esler MD, Krum H, Schlaich M, et al. Renal sympathetic denervation for treatment of drug- resistant hypertension: one- year results from the simplicity HTN- 2 randomized, controlled trial[J]. Circulation, 2012, 126:2976- 2982.
[2] Symplicity HTN- 2 Investigators. Renal sympathetic denervation in patients with treatment- resistant hypertension(the symplicity HTN- 2 trial): a randomized controlled trial[J]. Lancet, 2010,376: 1903- 1909.
[3] Papademetriou V, Worthley S, Tsioufis C, et al. Catheter- based renal denervation for the treatment of patients with drug- resistant hypertension: EnligTHN I: three- month data of a first in man study using a multi- electrode radiofrequency ablation catheter[J]. Circulation, 2012, 125: A19523.
[4] Bhatt DL, Kandzari DE, O’Neill WW, et al. A controlled trail of renal denervation for resistant hypertension[J]. N Engl J Med, 2014, 370:1393- 1401.
[5] Bohm M, Mahfound F, Ukena C. First report of the global SYMPLICITY registry on the effect of renal artery denervation in patients with uncontrolled hypertension[J]. Hypertension, 2015, 65: 766- 774.
[6] Kandzari DE, Bohm M, Mahfoud F, et al. Effect of renal denervation on blood pressure in the presence of antihypertensive drugs: 6- month efficacy and safety results from the SPYRAL HTN- ON MED proof- of- concept randomised trial[J]. Lancet,2018, 391:2346- 2355.
[7] Smith SM, Gong Y, Handberg E, et al. Predictors and outcomes of resistant hypertension among patients with coronary artery disease and hypertension[J]. J Hypertens, 2014, 32: 635- 643.
[8] 杨 宁, 程康安,李拥军. 去肾交感神经支配术与高血压[J]. 介入放射学杂志, 2012, 21:441- 446.
[9] Krum H, Schlaich MP, Sobotka PA, et al. Percutaneous renal denervation in patients with treatment- resistant hypertension: final 3- year report of the Symplicity HTN- 1 study[J]. Lancet, 2014, 383: 622–629.
[10] 潘 涛,郭金和,滕皋军. 经导管肾交感神经射频消融术临床研究进展[J]. 介入放射学杂志, 2015, 24:1113- 1118.
[11] Mahfoud F, Tunev S, Ewen S, et al. Impact of lesion placement on efficacy and safety of catheter- based radiofrequency renal ednervation[J]. J Am Coll Cardiol, 2015, 66:1766- 1775.
[12] Bohm M, Brilakis N, Mancia G, et al. TCT- 762 renal denervation treatment with the Symplicity Spyral multielectrode catheter: 6- month safety and blood pressure outcomes from the Global SYMPLICITY Registry[J]. J Am Coll Cardiol, 2016, 68(Suppl): B308.
[13] Fengler K, Ewen S, Hollriegel R, et al. Blood pressure response to main renal artery and combined main renal artery plus branch renal denervation in patients with resistant hypertension[J]. J Am Heart Assoc, 2017, 6: e006196.

备注/Memo

备注/Memo:
(收稿日期:2019- 11- 16)
(本文编辑:边 佶)
更新日期/Last Update: 2020-09-15