[1]王天成,马聪,肖煜东,等.利多卡因-表阿霉素-超液化碘油混合乳剂在肝癌TACE相关疼痛管理中的应用 [J].介入放射学杂志,2020,29(04):366-371.
 WANG Tiancheng,MA Cong,XIAO Yudong,et al.The application of lidocaine-epirubicin-lipiodol emulsion in the management of TACE-related pain in HCC patients[J].journal interventional radiology,2020,29(04):366-371.
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利多卡因-表阿霉素-超液化碘油混合乳剂在肝癌TACE相关疼痛管理中的应用
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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
29
期数:
2020年04
页码:
366-371
栏目:
肿瘤介入
出版日期:
2020-05-08

文章信息/Info

Title:
The application of lidocaine-epirubicin-lipiodol emulsion in the management of TACE-related pain in HCC patients
作者:
王天成马聪肖煜东张子曙
Author(s):
WANG Tiancheng MA Cong XIAO Yudong ZHANG Zishu.
Department of Radiology, Second Xiangya Hospital of Central South University, Changsha, Hunan Province 410011, China
关键词:
【关键词】 肝癌经动脉化疗栓塞术利多卡因疼痛管理
文献标志码:
A
摘要:
【摘要】 目的?探讨利多卡因-表阿霉素-超液化碘油乳剂在缓解TACE术中及术后患者疼痛的有效性及安全性。方法?采用前瞻性随机对照的研究方法,共纳入55例患者。运用最小化法动态随机将患者分为A组(n=28)与B组(n=27)。A组在栓塞前通过导管一次性注入利多卡因100 mg,再注入表阿霉素-超液化碘油乳剂,B组在栓塞术中注入利多卡因-表阿霉素-超液化碘油乳剂。两组利多卡因用量均为100 mg。观察并记录患者术中及术后72 h内的疼痛评分(使用视觉疼痛评分量表),比较两组患者的一般情况,术后不良反应及其他止痛药物使用量。计量资料用均数±标准差或中位数(四分位间距)表示,计数资料用百分比表示;两组患者之间计量资料比较使用独立样本t检验或Mann-Whitney U检验,计数资料比较用χ2检验或者Fisher精确检验;以P<0.05为差异有统计学意义。结果?两组患者的一般情况、碘油使用总量、TACE手术时长、表阿霉素用量及术后不良反应均无统计学差异(P>0.05)。B组在术中及术后4 h、8 h、24 h的疼痛评分均明显小于A组 (P<0.01),而在术前,术后48 h、72 h
两组间的疼痛评分差异无统计学意义(P>0.05)。B组患者TACE术后曲马多使用量小于A组患者
(P<0.05),两组患者术后哌替啶使用量差异无统计学意义(P>0.05)。结论?利多卡因-表阿霉素-超液化碘油乳剂具有延长利多卡因止痛时长的作用,可以在TACE术中和术后有效减轻患者疼痛程度,达到长时间的止痛效果,从而提高患者住院期间生活质量。

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备注/Memo

备注/Memo:
(收稿日期:2019-06-10)
(本文编辑:俞瑞纲)
更新日期/Last Update: 2020-05-06