[1]张训,徐燕能,张向琼,等.CalliSpheres载药微球联合碘化油治疗大肝癌14例[J].介入放射学杂志,2020,29(01):39-44.
　ZHANG Xun,XU Yanneng,ZHANG Xiangqiong,et al.CalliSpheres drug-eluting beads combined with lipiodol for TACE treatment of large liver cancer in 14 patients[J].journal interventional radiology,2020,29(01):39-44.
点击复制

CalliSpheres载药微球联合碘化油治疗大肝癌14例()

PDF下载中关闭

分享到：

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
29
期数:
2020年01
页码:
39-44
栏目:
肿瘤介入
出版日期:
2020-02-10

文章信息/Info

Title:
CalliSpheres drug-eluting beads combined with lipiodol for TACE treatment of large liver cancer in 14 patients
作者:
张训; 徐燕能; 张向琼; 胡伟; 袁罡; 马小燕; 斯光晏
Author(s):
ZHANG Xun;  XU Yanneng;  ZHANG Xiangqiong;  HU Wei;  YUAN Gang;  MA Xiaoyan;  SI Guangyan.
Department of Interventional Radiology, Affiliated Hospital of Traditional Chinese Medicine, Southwest Medical University, Luzhou, Sichuan Province 646000, China
关键词:
【关键词】　肝癌; 经导管动脉化疗栓塞; 可载药栓塞微球; 碘化油
文献标志码:
A
摘要:
【摘要】　目的?观察CalliSpheres载药微球联合碘化油治疗大肝癌的近期临床疗效及安全性。方法?回顾性分析2017年7月至2018年6月行TACE治疗的14例大肝癌患者，术中使用CalliSpheres载药微球联合碘化油治疗，采用mRECIST标准评价治疗效果，比较患者术前与术后肝功能及AFP变化，分析不良反应与并发症发生情况。结果?14例患者均接受CalliSpheres载药微球联合碘化油治疗，技术均获成功；随访6个月以上，患者术后1、3和6个月的疾病缓解率分别为85.7%、78.6%和64.3%，疾病控制率分别为92.9%、92.9%、78.6%；术后1个月AFP明显下降，与术前比较差异有统计学意义（P＜0.05）；术后7 d患者ALT和总胆红素（TBIL）明显升高，白蛋白（ALB）有所下降，与术前比较差异有统计学意义（P均＜0.05）；术后1个月肝功能指标基本恢复至术前基线水平，与术前比较差异均无统计学意义
（P＞0.05）；术后不良反应主要表现为轻度腹痛、低热、恶心、呕吐，但经对症处理后均在1周内得到缓解。结论?CalliSpheres载药微球联合碘化油治疗大肝癌有良好的近期疗效，安全可行，在达到与DEB-TACE相似效果的同时能减少载药微球剂量，从而减轻患者经济负担，其远期疗效仍待进一步研究。

参考文献/References:

1 Park JW, Chen M, Colombo M, et al. Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE studyJ. Liver Int, 2015, 35:2155-2166.
2 European Association for the Study of the Liver. EASL Clinical Practice Guidelines: management of hepatocellular carcinomaJ. J Hepatol, 2018, 69:182-236.
3 中华人民共和国国家卫生和计划生育委员会. 原发性肝癌诊疗规范（2017年版）J. 临床肝胆病杂志， 2017， 33:1419-1431.
4 安天志，高?嵩， 靳?勇， 等. 中国肝细胞癌经动脉化疗栓塞治疗（TACE）临床实践指南J. 介入放射学杂志， 2018， 27:1117-1126.
5 周永祥， 张景俊， 罗志刚， 等. CalliSpheres?载药微球栓塞治疗高龄肝癌患者的安全性分析J. 广东医学， 2018， 39:1561-1565.
6 Wu B, Zhou J, Ling G, et al. CalliSpheres drug-eluting beads versus lipiodol transarterial chemoembolization in the treatment of hepatocellular carcinoma: a short-term efficacy and safety studyJ. World J Surg Oncol, 2018, 16:69.
7 刘?金，曹?刚，张根山， 等. 国产CalliSpheres载药微球治疗原发性肝癌12例J. 介入放射学杂志, 2017, 26:993-998.
8 de Baere T, Arai Y, Lencioni R, et al. Treatment of liver tumors with lipiodol TACE: technical recommendations from experts opinionJ. Cardiovasc Intervent Radiol, 2016, 39:334-343.
9 Liu YS, Ou MC, Tsai YS, et al. Transarterial chemoembolization using gelatin sponges or microspheres plus lipiodol-doxorubicin versus doxorubicin-loaded beads for the treatment of hepatocellular carcinomaJ. Korean J Radiol, 2015, 16:125-132.
10 徐彦哲， 丁佑铭， 杨?阳. 微球联合碘化油栓塞化疗治疗肝细胞癌的Meta分析J. 中华肝胆外科杂志， 2014, 20:24-28.
11 官泳松， 贺?庆， 靳?勇， 等. 迦俐生聚乙烯醇栓塞微球的研制J. 中华肝脏病杂志， 2016， 24:549-551.
12 Facciorusso A. Drug-eluting beads transarterial chemoembolization for hepatocellular carcinoma: current state of the artJ. World J Gastroenterol, 2018, 24:161-169.
13 徐文杰， 曹?刚， 张根山， 等. 聚乙烯醇栓塞微球可载药微球介入治疗中晚期肝癌的临床疗效及安全性观察J. 实用癌症杂志， 2017， 32:1999-2001.
14 Golfieri R, Giampalma E, Renzulli M, et al. Randomised controlled trial of doxorubicin-eluting beads vs conventional chemoembolisation for hepatocellular carcinomaJ. Br J Cancer, 2014, 111:255-264.
15 Wu GC, Chan ED, Chou YC, et al. Risk factors for the development of pulmonary oil embolism after transcatheter arterial chemoembolization of hepatic tumorsJ. Anticancer Drugs, 2014, 25:976-981.
16 Zhong C, Guo RP, Li JQ, et al. A randomized controlled trial of hepatectomy with adjuvant transcatheter arterial chemoembolization versus hepatectomy alone for Stage ⅢA hepatocellular carcinomaJ. J Cancer Res Clin Oncol, 2009, 135:1437-1445.
17 赵?倩，颜志平. 载药微球经导管动脉化疗栓塞治疗肝癌研究进展J. 介入放射学杂志， 2017， 26:1052-1056.
18 崔?鹏， 杜小丽， 周?瀚， 等. TACE治疗肝癌伴门脉癌栓患者的预后分析J. 介入放射学杂志， 2018, 27:266-271.
19 Chern MC, Chuang VP, Liang CT, et al. Transcatheter arterial chemoembolization for advanced hepatocellular carcinoma with portal vein invasion: safety, efficacy, and prognostic factorsJ. J Vasc Interv Radiol, 2014, 25:32-40.


相似文献/References:

[1]官泳松,贺庆.肝癌介入治疗中应用p５３的几个要点[J].介入放射学杂志,2008,(11):761.
　GUAN Yongsong,HE Qing.Essentials in clinical application of p５３for tumors intervention－example of liver cancer[J].journal interventional radiology,2008,(01):761.
[2]沈海洋,杨光,刘瑞宝,等.肝右叶前、后段原发性肝癌动脉化疗栓塞术后近期疗效比较[J].介入放射学杂志,2010,(05):382.
　SHEN Haiyang,YANG Guang,LIU Ruibao,et al.Short－term effects of TACE for primary hepatocellular carcinoma of the right hepatic lobe：a comparison between the lesions in anterior segments and the lesions in posterior segments[J].journal interventional radiology,2010,(01):382.
[3]杨永波,程红岩.肝动脉化疗栓塞治疗中碘油用量的现状与研究进展[J].介入放射学杂志,2012,(04):348.
　.Ｔｈｅ ｖｏｌｕｍｅ ｏｆ Ｌｉｐｉｏｄｏｌ ｕｓｅｄ ｉｎ ＴＡＣＥ： ｉｔｓ ｃｕｒｒｅｎｔ ｓｉｔｕａｔｉｏｎ ａｎｄ ｒｅｓｅａｒｃｈ ｐｒｏｇｒｅｓｓ [J].journal interventional radiology,2012,(01):348.
[4]帕哈尔丁·白克热,杨树法,黄伍奎,等.肝动脉化疗栓塞联合射频消融术治疗３０例原发性大肝癌的疗效评价[J].介入放射学杂志,2012,(04):322.
　,,et al.ＴＡＣＥ ｃｏｍｂｉｎｅｄ ｗｉｔｈ ｒａｄｉｏｆｒｅｑｕｅｎｃｙ ａｂｌａｔｉｏｎ ｆｏｒ ｍａｓｓｉｖｅ ｐｒｉｍａｒｙ ｈｅｐａｔｏｃｅｌｌｕｌａｒ ｃａｒｃｉｎｏｍａｓ： ａ ｃｌｉｎｉｃａｌ ｔｈｅｒａｐｅｕｔｉｃ ｅｖａｌｕａｔｉｏｎ [J].journal interventional radiology,2012,(01):322.
[5]张　　　磊,陆骊工,李　　　勇,等.门静脉支架联合肝动脉化疗栓塞治疗肝癌伴门静脉癌栓的临床研究[J].介入放射学杂志,2011,(12):968.
　ZHANG Lei,LU Li-gong,LI Yong,et al.Portal vein stent placement combined with TACE for the treatment of hepatocellular carcinoma associated with tumor thrombus in portal vein[J].journal interventional radiology,2011,(01):968.
[6]敖 劲,张跃伟,徐 克. 明胶海绵微粒经动脉栓塞治疗原发性肝癌的研究现状[J].介入放射学杂志,2011,(12):1010.
　AO Jin,ZHANG Yue-wei,XU Ke..Gelatin sponge particle used as an embolic agent in transcatheter arterial chemoembolization treatment for primary hepatocellular carcinoma: its current situation in research[J].journal interventional radiology,2011,(01):1010.
[7]杜丹丹,吕维富. 肝癌射频消融后的影像学评价[J].介入放射学杂志,2012,(01):75.
　DU Dan dan,Lv Wei fu..Imaging evaluation of liver cancer after radiofrequency ablation therapy[J].journal interventional radiology,2012,(01):75.
[8]赵 艳,韩国宏,白 苇,等. 药物缓释微球肝动脉化疗栓塞治疗肝癌研究进展[J].介入放射学杂志,2012,(01):78.
　ZHAO Yan,HAN Guo-hong,BAI Wei,et al.Transarterial chemoembolization with drug-eluting beads for hepatocellular carcinoma: its research progress[J].journal interventional radiology,2012,(01):78.
[9]何海涛,刘 圣,刘建秦,等. 肝癌TACE术并发脑碘油栓塞二例并文献复习[J].介入放射学杂志,2012,(08):682.
　HE Hai- tao,LIU sheng,LIU Jian- qing,et al. Cerebral Lipiodol embolism occurred after transcatheter arterial chemoembolization for hepatocellular carcinoma: report of two cases with literature review[J].journal interventional radiology,2012,(01):682.
[10]罗中华,秦 勉,张学昕,等.原发性肝癌合并下腔静脉及右心房癌栓的动脉内化疗栓塞治疗[J].介入放射学杂志,2012,(12):1035.
　LUO Zhong? hua,QIN Mian,ZHANG Xue? xin,et al. Transcatheter arterial chemoembolization for hepatocellular carcinoma complicated by tumor thrombus in inferior vena cava and right atrium[J].journal interventional radiology,2012,(01):1035.

备注/Memo

备注/Memo:
（收稿日期：2019-03-19）
（本文编辑：俞瑞纲）
更新日期/Last Update: 2020-02-08