[1]陈 亮,丁 健,王永利,等.镁合金支架植入兔腹主动脉后降解时间及血管内膜增生观察 [J].介入放射学杂志,2017,(05):443-446.
 CHEN Liang,DING Jian,WANG Yongli,et al.The degradation time and the intimal hyperplasia of biodegradable magnesium alloy stent implanted in the abdominal aorta of experimental rabbits[J].journal interventional radiology,2017,(05):443-446.
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镁合金支架植入兔腹主动脉后降解时间及血管内膜增生观察

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2017年05期
页码:
443-446
栏目:
实验研究
出版日期:
2017-05-25

文章信息/Info

Title:
The degradation time and the intimal hyperplasia of biodegradable magnesium alloy stent implanted in the abdominal aorta of experimental rabbits
作者:
陈 亮 丁 健 王永利 王征宇 谢 科 彭志清 刘 强
Author(s):
CHEN Liang DING Jian WANG Yongli WANG Zhengyu XIE Ke PENG Zhiqing LIU Qiang
Department of Interventional Radiology, South Branch of Affiliated Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai 201499, China
关键词:
【关键词】 可降解镁合金支架 腹主动脉 降解时间 血管内膜增生
文献标志码:
A
摘要:
【摘要】 目的 观察新型可降解镁合金支架——MPM植入兔腹主动脉后降解时间及血管内膜增生。方法 24只新西兰大白兔随机分为4组,每组6只,分别于距左肾动脉水平下1 cm腹主动脉处植入MPM支架各1枚。术后30、60、90、180 d分别复查腹主动脉造影,分离支架段血管进行观察。采用SPSS20.0软件对数据进行分析。结果 24只实验兔在随访期间存活良好。植入支架逐渐降解,180 d时基本降解;血管内膜增生,90 d时达峰值,整个降解过程血管通畅。结论 可降解镁合金支架MPM完全降解时间为182 d,可满足血管正性重塑。

参考文献/References:

[1] 尹铁英, 王亚洲, 王贵学. 血管支架内再狭窄机制的研究现状[A]. 第一届全国介入医学工程学术会议论文集[C]. 2007年.
[2] 卢 旺, 刘建民. 支架植入后再狭窄防治的研究进展[J]. 介 入放射学杂志, 2003, 12: 230- 232.
[3] 肖健勇, 刘 寅. 镁合金可吸收金属支架的研究进展[J]. 天津医药, 2011, 39: 285- 287.
[4] 丁 健. 可降解镁合金支架MPM 置入兔腹主动脉后的实验研究[D]. 苏州: 苏州大学, 2014.
[5] 陈 亮, 丁 健, 王永利, 等. 镁合金支架植入兔腹主动脉后降解时间观察[J]. 介入放射学杂志, 2015, 24: 994- 997.
[6] Moscucci M, Ricciardi M, Eagle KA, et al. Frequency, predictors, and appropriateness of blood transfusion after percutaneous coronary interventions[J]. Am J Cardiol, 1998, 81: 702- 707.
[7] 张春晓. 冠状动脉支架内再狭窄的相关因素分析[D]. 天津: 天津医科大学, 2012.
[8] Moravej M, Mantovani D. Biodegradable metals for cardiovascular stent application: interests and new opportunities[J]. Int J Mol Sci, 2011, 12: 4250- 4270.
[9] Garg S, Serruys PW. Coronary stents: looking forward[J]. J Am Coll Cardiol, 2010, 56: S43- S78.
[10] Bowen PK, Gelbaugh JA, Mercier PJ, et al. Tensile testing as anovel method for quantitatively evaluating bioabsorbable material degradation[J]. J Biomed Mater Res B Appl Biomater, 2012, 100: 2101- 2113.
[11] 谭志刚, 周 倩, 蒋宇钢. 生物可降解镁合金血管支架:缺点及未来研究趋势[J]. 中国组织工程研究, 2015, 19: 1284- 1288.
[12] Ghimire G, Spiro J, Kharbanda R, et al. Initial evidence for the return of coronary vasoreactivity following the absorption of bioabsorbable magnesium alloy coronary stents[J]. EuroInter- vention, 2009, 4: 481- 484.
[13] Curcio A, Torella D, Indolfi C. Mechanisms of smooth muscle cell proliferation and endothelial regeneration after vascular injury and stenting: approach to therapy[J]. Circ J, 2011, 75: 1287- 1296.
[14] 李海伟, 徐 克, 杨 柯, 等. 可降解AZ31镁合金支架在兔腹主动脉的降解性能研究[J]. 介入放射学杂志, 2010, 19: 315-317.

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备注/Memo

备注/Memo:
(收稿日期:2016-09-06)
(本文编辑:边 佶)
更新日期/Last Update: 2017-05-15