[1]李忠海,曾健滢,陈梓晴,等.磁共振弥散加权成像观察胰腺癌冷冻术后近期疗效的应用价值[J].介入放射学杂志,2017,(02):142-146.
 LI Zhonghai,ZENG Jianying,CHEN Ziqing,et al.Clinical application of MR diffusion-weighted imaging in evaluating the short-term curative effect of cryoablation for pancreatic carcinoma[J].journal interventional radiology,2017,(02):142-146.
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磁共振弥散加权成像观察胰腺癌冷冻术后近期疗效的应用价值 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2017年02期
页码:
142-146
栏目:
非血管介入
出版日期:
2017-02-25

文章信息/Info

Title:
Clinical application of MR diffusion-weighted imaging in evaluating the short-term curative effect of cryoablation for pancreatic carcinoma
作者:
李忠海 曾健滢 陈梓晴 李建男 张 利 牛立志 徐克成
Author(s):
LI Zhonghai ZENG Jianying CHEN Ziqing LI Jiannan ZHANG Li NIU Lizhi XU Kecheng
Ulanhot Municipal People’s Hospital, Ulanhot, Xing’an Meng, Inner Mongolia Autonomous Region 137400, China
关键词:
【关键词】 磁共振弥散加权成像 表观弥散系数 胰腺癌 冷冻消融
文献标志码:
A
摘要:
【摘要】 目的 探讨采用磁共振弥散加权成像(MRI-DWI)评估胰腺癌冷冻术后肿瘤坏死及肿瘤残存的应用价值。方法 对接受冷冻治疗的26例胰腺癌患者行T1WI、T2WI常规MRI平扫、DWI序列及动态增强扫描。观察胰腺癌冷冻前后MRI信号改变。测量并比较正常胰腺、术前肿瘤组织及术后残存、坏死组织的表现弥散系数(ADC)值。评价肿瘤组织ADC值与肿瘤大小的相关性,不同肿瘤直径、肿瘤位置及分期表现ADC值的差异。结果 26例患者中16例肿瘤完全坏死,冷冻坏死的胰腺肿瘤组织在T1WI图像上呈低信号,T2WI呈高信号,DWI呈低信号,动态增强无强化。活性肿瘤组织残留9例(其中7例肿瘤直径>5.0 cm),残留率为34.6%。ADC值由低到高依次为:术前胰腺肿瘤组织(1.022±0.126)×10-3 mm2/s、术后残存肿瘤组织(1.130±0.155)×10-3 mm2/s、正常胰腺组织(1.924±0.124)×10-3 mm2/s及术后坏死组织(2.312±0.214)×10-3 mm2/s。术前胰腺肿瘤组织ADC值与术后残存肿瘤组织相比,差异无统计学意义(P=0.452),与正常胰腺组织、术后坏死组织相比,差异有显著统计学意义(P<0.001)。胰腺肿瘤ADC值与肿瘤大小呈负相关(R=-0.43,P=0.027 2),与肿瘤位置、肿瘤分期无关(P=0.738 8,P=0.089 5)。结论 DWI能有效鉴别胰腺癌冷冻治疗后的病灶坏死及残存,为进一步临床诊治提供依据。

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备注/Memo

备注/Memo:
(收稿日期:2016-04-30)
(本文编辑:俞瑞纲)
更新日期/Last Update: 2017-02-13