[1]刘振良,贾国渠.阿托伐他汀序贯治疗对接受急症PCI术急性心肌梗死患者缺血修饰白蛋白的影响[J].介入放射学杂志,2016,(09):755-758.
　LIU Zhen- liang,JIA Guo- qu.Effect of sequential therapy of atorvastatin on the levels of ischemia modified albumin in patients undergoing emergency percutaneous coronary intervention for acute ST- segment elevation myocardial infarction[J].journal interventional radiology,2016,(09):755-758.
点击复制

阿托伐他汀序贯治疗对接受急症PCI术急性心肌梗死患者缺血修饰白蛋白的影响 ()

PDF下载中关闭

分享到：

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2016年09期
页码:
755-758
栏目:
心脏介入
出版日期:
2016-09-25

文章信息/Info

Title:
Effect of sequential therapy of atorvastatin on the levels of ischemia modified albumin in patients undergoing emergency percutaneous coronary intervention for acute ST- segment elevation myocardial infarction
作者:
刘振良;  贾国渠
Author(s):
LIU Zhen- liang;  JIA Guo- qu
Department of Cardiology， No.416 Hospital of Nuclear Industry， Chengdu， Sichuan Province 610051， China
关键词:
【关键词】 序贯治疗;  经皮冠状动脉介入治疗;  缺血修饰白蛋白
文献标志码:
A
摘要:
【摘要】 目的 探讨阿托伐他汀序贯治疗对接受急症经皮冠状动脉介入治疗（PCI）急性心肌梗死患者血清缺血修饰白蛋白（IMA）的影响。方法 收集2010年9月至2014年1月收治的符合纳入标准的83例急性ST段抬高型心肌梗死（STEMI）患者，随机分为阿托伐他汀常规治疗组（n=40，对照组）和序贯治疗组（n=43），对照组阿托伐他汀20 mg/d，序贯治疗组术前80 mg/d，术后40 mg/d，3个月后20 mg/d。观察术前及术后2、4、6、8、10、12、14 h IMA，术中及术后6个月主要心血管不良事件（MACE）。结果 序贯治疗组PCI术后血清IMA水平明显低于常规治疗组，差异有统计学意义（P＜0.05）；序贯治疗组术后6个月MACE发生率明显明显低于常规治疗组，差异有统计学意义（P＜0.05）。结论 阿托伐他汀序贯治疗可显著改善急症PCI患者心肌缺血，对心肌起主要保护作用，并降低术后MACE发生率，安全有效。

参考文献/References:

［1］ 中华医学会心血管病学分会介入心脏病学组， 中华心血管病杂志编辑委员会. 中国经皮冠状动脉介入治疗指南2012（简本）［J］. 中华心血管病杂志， 2012， 40： 271- 277.
［2］ 霍 勇， 葛均波， 韩雅玲， 等． 急性冠状动脉综合征患者强化他汀治疗专家共识［J］. 中国介入心脏病学杂志， 2014， 22： 4- 6．
［3］ 金 玫. 急性ST段抬高型心肌梗死的诊断和治疗指南［J］. 中华心血管病杂志， 2010， 38： 675- 690.
［4］ 替罗非班治疗冠状动脉粥样硬化性心脏病专家共识组．替罗非班在冠状动脉粥样硬化性心脏病治疗的中国专家共识［J］． 中华内科杂志， 2013， 52： 434- 439．
［5］ Roy D, Quiles J, Gaze DC, et al. Role of reactive oxygen species on the formation of the novel diagnostic marker ischaemia modified albumin［J］. Heart, 2006, 92: 113- 114.
［6］ Collinson PO, Gaze DC. Biomarkers of cardiovascular damage and dysfunction: an overview［J］. Heart Lung Circ, 2007, 16: S71- S82.
［7］ Acikgoz S, Edebali N, Barut F, et al. Ischemia modified albumin increase indicating cardiac damage after experimental subarachnoid hemorrhage［J］. BMC Neurosci, 2014, 15: 33.
［8］ Task Force on the management of ST- segment elevation acute myocardial infarction of the European Society of Cardiology （ESC）, Steg PG, James SK, et al. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST- segment elevation［J］. Eur Heart J, 2012, 33: 2569- 2619.
［9］ Tan J, Hua Q. Correlations between serum inflammation factors and left ventricular remodeling in acute ST segment elevation myocardial infarction［J］. Yonsei Med J, 2012, 53: 501- 507.
［10］ Kiyici A, Mehmetoglu I, Karaoglan H, et al. Ischemia- modified albumin levels in patients with end- stage renal disease patients on hemodialysis: does albumin analysis method affect albumin- adjusted ischemia- modified albumin levels?［J］. J Clin Lab Anal, 2010, 24: 273- 277.
［11］ Lee DH, Jeon HK, Park HJ, et al. Change in ischemia- modified albumin and its clinical significance during exercise stress testing［J］. Circ J, 2010, 74: 484- 489.
［12］ American College of Emergency Physicians, Society for Cardiovas- cular Angiography and Interventions, O’Gara PT, et al. 2013 ACCF/AHA guideline for the management of ST- elevation myocar- dial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines［J］. J Am Coll Cardiol, 2013, 61: e78- e140.
［13］ Di Sciascio G, Patti G, Pasceri V, et al. Efficacy of atorvastatin reload in patients on chronic statin therapy undergoing percutaneous coronary intervention: results of the ARMYDA- RECAPTURE （Atorvastatin for Reduction of Myocardial Damage During Angioplasty） Randomized Trial［J］. J Am Coll Cardiol, 2009, 54: 558- 565.
［14］ Otake H, Shite J, Shinke T, et al. Relation between plasma adiponectin, high- sensitivity C- reactive protein, and coronary plaque components in patients with acute coronary syndrome［J］. Am J Cardiol, 2008, 101: 1- 7.
［15］ Patti G, Pasceri V, Colonna G, et al. Atorvastatin pretreatment improves outcomes in patients with acute coronary syndromes undergoing early percutaneous coronary intervention: results of the ARMYDA- ACS randomized trial［J］. J Am Coll Cardiol, 2007, 49: 1272- 1278.
［16］ Nusca A, Melfi R, Patti G, et al. Statin loading for acute coronary syndromes［J］. Curr Opin Cardiol, 2010, 25: 373- 378.
［17］ Briguori C, Visconti G, Focaccio A, et al. Novel approaches for preventing or limiting events（Naples） Ⅱ trial: impact of a single high loading dose of atorvastatin on periprocedural myocardial infarction［J］. J Am Coll Cardiol, 2009, 54: 2157- 2163.

相似文献/References:

[1]徐翠荣,李国宏,陈 泳,等. 临床路径在急性心肌梗死介入治疗整体护理中的应用[J].介入放射学杂志,2012,(12):1046.
　XU Cui? rong,LI Guo? hong,CHEN Yong,et al. The application of clinical nursing path in holistic nursing care for patients with acute myocardial infarction treated with emergency percutaneous coronary intervention[J].journal interventional radiology,2012,(09):1046.
[2]彭育红,汝磊生,王冬梅,等.国产无聚合物紫杉醇微孔载药支架与雷帕霉素涂层支架对比治疗急性心肌梗死[J].介入放射学杂志,2013,(06):458.
　PENG Yu? hong,RU Lei? sheng,WANG Dong? mei,et al. Domestic polymer- free paclitaxel- eluting stent and polymer-based rapamycin- eluting stent for the treatment of acute myocardial infarction： a comparison study[J].journal interventional radiology,2013,(09):458.
[3]孙俊翔,陈燕春,殷云杰,等.脂蛋白（a）与稳定型心绞痛患者经皮冠状动脉介入治疗围术期心肌损伤研究[J].介入放射学杂志,2019,28(01):19.
　SUN Junxiang,CHEN Yanchun,YIN Yunjie,et al.The correlation between lipoprotein level and perioperative myocardial injury in patients with stable angina after percutaneous coronary intervention[J].journal interventional radiology,2019,28(09):19.
[4]李文庆,程志勇,魏明霞,等.血管内超声指导介入治疗冠状动脉分叉病变临床研究[J].介入放射学杂志,2015,(04):292.
　LI Wen qing,CHENG Zhi yong,WEI Ming xia,et al.Intravascular ultrasound guided interventional treatment of coronary true bifurcation lesions： a clinical study[J].journal interventional radiology,2015,(09):292.
[5]丁 力,庄国红,丁 飚.静脉水化和口服水化预防心功能不全患者对比剂肾病临床应用[J].介入放射学杂志,2016,(01):15.
　DING Li,ZHUANG Guo- hong,DING Biao.Clinical application of intravenous hydration or oral hydration in preventing contrast- induced nephropathy in patients with cardiac insufficiency[J].journal interventional radiology,2016,(09):15.
[6]余云华,姜梦妮,郑 兴.上海市户籍冠心病患者经皮冠状动脉介入治疗10年变化趋势研究[J].介入放射学杂志,2016,(04):298.
　YU Yun- hua,JIANG Meng- ni,ZHENG Xing.Study on the trend of percutaneous coronary intervention in the past 10 years in treating Shanghai patients with coronary heart disease at Changhai Hospital[J].journal interventional radiology,2016,(09):298.
[7]曾松柏,曾 山,张 梅,等.老年患者择期冠状动脉介入治疗中低剂量比伐卢定安全性观察[J].介入放射学杂志,2016,(03):250.
　ZENG Song- bai,ZENG Shan,ZHANG Mei,et al.The use of low- dose bivalirudin in elderly patients receiving elective percutaneous coronary intervention： observation of its safety[J].journal interventional radiology,2016,(09):250.
[8]于亚梅,余云华,李 然,等.老年冠心病患者介入治疗血运重建方式临床疗效分析[J].介入放射学杂志,2017,(01):6.
　YU Ya- mei,YU Yun- hua,LI Ran,et al.Interventional revascularization therapy for the reconstruction of blood circulation in aged patients with coronary heart disease： analysis of clinical curative effect[J].journal interventional radiology,2017,(09):6.
[9]漆红梅,吴志勇,颜 琼,等.导引导丝操作托盘在经皮冠状动脉介入治疗中的应用 [J].介入放射学杂志,2017,(07):585.
　QI Hongmei,WU Zhiyong,YAN Qiong,et al.Application of self- made guided wire operating- tray in performing percutaneous coronary intervention[J].journal interventional radiology,2017,(09):585.
[10]陈燕春,殷云杰,徐 亮,等.脂蛋白相关磷脂酶A2预测稳定型心绞痛患者经皮冠状动脉介入治疗围手术期心肌损伤研究 [J].介入放射学杂志,2017,(12):1073.
　CHEN Yanchun,YIN Yunjie,XU Liang,et al.Predictive value of lipoprotein- associated phospholipase A2 on perioperative myocardial injury in patients with stable angina after percutaneous coronary intervention[J].journal interventional radiology,2017,(09):1073.

备注/Memo

备注/Memo:
（收稿日期：２０１6-０3-26）
（本文编辑：边 佶）
更新日期/Last Update: 2016-09-19