[1]陈 越,蒋霆辉,刘 艳,等.姜黄素对肝癌大鼠碘油栓塞后信号传导与转录激活因子3及其磷酸化形式表达的影响[J].介入放射学杂志,2016,(10):911-915.
CHEN Yue,JIANG Ting- hui,LIU Yan,et al.The effect of curcumin on the expression of STAT3 and pSTAT3 in experimental rats with transplanted liver cancer after lipiodol embolization[J].journal interventional radiology,2016,(10):911-915.
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姜黄素对肝癌大鼠碘油栓塞后信号传导与转录激活因子3及其磷酸化形式表达的影响 ()
《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]
- 卷:
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- 期数:
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2016年10期
- 页码:
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911-915
- 栏目:
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临床研究
- 出版日期:
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2016-10-25
文章信息/Info
- Title:
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The effect of curcumin on the expression of STAT3 and pSTAT3 in experimental rats with transplanted liver cancer after lipiodol embolization
- 作者:
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陈 越; 蒋霆辉; 刘 艳; 茅爱武
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- Author(s):
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CHEN Yue; JIANG Ting- hui; LIU Yan; MAO Ai- wu
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Imaging Interventional Department, Affiliated Tongren Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200336, China
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- 关键词:
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【关键词】 姜黄素; 移植性肝癌模型; 碘油栓塞; STAT3; pSTAT3
- 文献标志码:
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A
- 摘要:
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【摘要】 目的 研究姜黄素对大鼠移植性肝癌模型碘油栓塞后生存时间、肿瘤生长率及对信号转导和转录活化因子3(STAT3)及其磷酸化形式pSTAT3表达的影响。方法 建立SD 大鼠移植性肝癌模型,将建模成功SD 大鼠随机分为模型组、碘油组、姜黄素组、碘油联合姜黄素组,根据组别经肝动脉分别灌注生理盐水、超液态碘油和(或)姜黄素,观察实验动物的生存时间、肿瘤生长率,Western blot法检测肿瘤边缘组织中STAT3及pSTAT3表达水平。结果 碘油联合姜黄素组与模型组、姜黄素组、碘油组相比,生存时间明显延长(P<0.01)。姜黄素组、碘油组比较差异无统计学意义(P>0.05), 治疗后模型组、姜黄素组、碘油组肿瘤体积较治疗前明显增大(P<0.01),姜黄素组、碘油组肿瘤生长率均低于模型组(P<0.01);碘油联合姜黄素组肿瘤体积与治疗前相比无明显改变(P>0.05),肿瘤生长率明显低于其它3组(P<0.01)。碘油联合姜黄素组STAT3及pSTAT3表达水平明显低于模型组。结论 姜黄素可抑制大鼠移植性肝癌模型碘油栓塞后肿瘤组织中STAT3及其磷酸化形式pSTAT3表达水平,同时本实验提示姜黄素与碘油栓塞联合治疗肝癌可能具有良好的应用前景。
参考文献/References:
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备注/Memo
- 备注/Memo:
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(收稿日期:2016-03-17)
(本文编辑:俞瑞纲)
更新日期/Last Update:
2016-10-20