[1]钟景阳,杜晓光,孙建彬.抗凝与局部溶栓治疗颅内静脉窦血栓形成对比分析[J].介入放射学杂志,2016,(03):257-260.
　ZHONG Jing- yang,DU Xiao- guang,SUN Jian- bin.Anticoagulant therapy and local thrombolytic therapy for intracranial venous sinus thrombosis： a comparative analysis of curative effect[J].journal interventional radiology,2016,(03):257-260.
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抗凝与局部溶栓治疗颅内静脉窦血栓形成对比分析 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2016年03期
页码:
257-260
栏目:
临床研究
出版日期:
2016-03-25

文章信息/Info

Title:
Anticoagulant therapy and local thrombolytic therapy for intracranial venous sinus thrombosis： a comparative analysis of curative effect
作者:
钟景阳;  杜晓光;  孙建彬
Author(s):
ZHONG Jing- yang;  DU Xiao- guang;  SUN Jian- bin
Department of Neurosurgery， Weifang Municipal Hospital of Traditional Chinese Medicine， Weifang， Shandong Province 261041， China
关键词:
【关键词】 静脉窦血栓;  抗凝;  溶栓;  疗效
文献标志码:
A
摘要:
【摘要】 目的 对比评价单纯抗凝与血管内局部溶栓结合抗凝治疗颅内静脉窦血栓形成（CVST）的效果。方法 收集采用单纯抗凝治疗和局部溶栓结合抗凝治疗的CVST患者各30例，单纯抗凝组患者接受皮下注射低分子肝素，后改为口服华法林治疗12个月；局部溶栓结合抗凝组患者分别接受静脉窦内接触性溶栓（18例）、颈内动脉溶栓（6例）、静脉窦内接触性溶栓结合颈内动脉溶栓（6例）治疗，术后常规口服华法林12个月。结果 局部溶栓结合抗凝组30例患者静脉窦主干实现再通，有2例窦内接触性溶栓患者出现颅内出血增多并发症；单纯抗凝组27例患者静脉窦主干实现再通，3例患者影像学显示再通不明显，但临床症状改善，无出血并发症。出院前单纯抗凝组患者和局部溶栓结合抗凝组患者Glasgow昏迷量表评分、改良Rankin 量表评分分别为13.4±1.6、1.8±0.7和14.2±1.3、1.4±0.7，与治疗前相比差异均有统计学意义（P＜0.05）。出院后6、12个月随访时局部溶栓结合抗凝组患者恢复好于单纯抗凝组，单纯抗凝组有2例患者自觉偶发头痛，其中1例为CVST复发。结论 局部溶栓结合抗凝治疗CVST是安全有效的，可根据患者具体情况选择不同溶栓治疗手段。

参考文献/References:

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备注/Memo

备注/Memo:
（收稿日期：２０１5-０6-3０）
（本文编辑：边 佶）
更新日期/Last Update: 2016-03-22