[1]李 菁,王 珏,谭华桥.颈动脉分叉部动脉瘤模型形态学、血流动力学和组织病理学研究[J].介入放射学杂志,2015,(10):890-896.
 LI Jing,WANG Jue,TAN Hua- qiao.Carotid artery bifurcation aneurysm model: a morphological, hemodynamic and histopathological study[J].journal interventional radiology,2015,(10):890-896.
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颈动脉分叉部动脉瘤模型形态学、血流动力学和组织病理学研究 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年10期
页码:
890-896
栏目:
实验研究
出版日期:
2015-10-25

文章信息/Info

Title:
Carotid artery bifurcation aneurysm model: a morphological, hemodynamic and histopathological study
作者:
李 菁 王 珏 谭华桥
Author(s):
LI Jing WANG Jue TAN Hua- qiao
Department of Diagnostic and Interventional Radiology, Affiliated Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai 200233, China
关键词:
【关键词】 动脉瘤 动物模型 颈动脉 血流动力学 组织病理学
文献标志码:
A
摘要:
【摘要】 目的 建立犬动物模型,研究特定血流动力学变化及动脉壁退化是否会导致动脉瘤发生发展。方法 建立18只犬颈总动脉(CCA)新分叉模型,随机分组为弹力蛋白酶处理组(EBG,n=9)和分叉模型对照组(CBG,n=9);同时设弹力蛋白酶处理直段CCA对照组(ESG,n=3)。术后即刻,术后12周、24周分别行血管造影及血流动力学分析,术后12周和24周行组织病理学分析。结果 血管造影显示EBG组5只犬模型CCA分叉顶部出现新生动脉瘤形成,瘤体平均直径(3.2±0.4) mm,CBG组和ESG组均未观察到新生动脉瘤形成;EBG组新生动脉瘤在随访期间未见破裂。组织学分析显示EBG组内层弹力膜不连续、弹力纤维断裂、肌层变薄、平滑肌细胞减少,炎性细胞(巨噬细胞)浸润及MMP- 2、MMP- 9表达增多(与CBG组和ESG组对比,P<0.001)。血流动力学分析显示EBG组分叉顶部壁面切应力减低、血流速度减慢、相对压力和总压力最高,动脉壁重塑后均恢复正常。结论 本实验表明动脉壁退化和动脉分叉处血流动力学作用可导致犬模型新生动脉瘤形成。

参考文献/References:

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备注/Memo

备注/Memo:
(收稿日期:2015-01-24)
(本文编辑:边 佶)
更新日期/Last Update: 2015-10-19