[1]陆 健,张丽云,王忠敏,等.组织间近距离125I放射性粒子治疗转移瘤硬膜外脊髓压迫症16例[J].介入放射学杂志,2015,(08):693-697.
　LU Jian,ZHANG Li- yun,WANG Zhong- min,et al.125I radioactive seed interstitial brachytherapy for the treatment of metastatic epidural spinal cord compression[J].journal interventional radiology,2015,(08):693-697.
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组织间近距离125I放射性粒子治疗转移瘤硬膜外脊髓压迫症16例()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年08期
页码:
693-697
栏目:
非血管介入
出版日期:
2015-08-25

文章信息/Info

Title:
125I radioactive seed interstitial brachytherapy for the treatment of metastatic epidural spinal cord compression
作者:
陆 健;  张丽云;  王忠敏;  滕皋军;  陈克敏;  陈志瑾;  贡 桔
Author(s):
LU Jian;  ZHANG Li- yun;  WANG Zhong- min;  TENG Gao- jun;  CHEN Ke- min;  CHEN Zhi- jin;  GONG Ju
Department of Radiology， Affiliated Ruijin Hospital Luwan Branch， School of Medicine， Shanghai Jiaotong University， Shanghai 200020， China
关键词:
【关键词】 转移瘤硬膜外脊髓压迫症;  CT引导;  125I粒子;  近距离治疗
文献标志码:
A
摘要:
【摘要】 目的 探讨125I放射性粒子组织间植入治疗转移瘤硬膜外脊髓压迫症（MESCC）的疗效及患者的生存质量。方法 16例无法手术或放疗的MESCC患者，在CT引导下行病灶内125I放射性粒子植入术。根据肿瘤大小植入粒子数6～45颗，粒子活度0.50～0.80 mCi，肿瘤匹配周缘剂量（MPD）为80～140 Gy。应用视觉模拟评分（VAS）评价患者治疗前、后疼痛情况，应用美国脊髓损伤协会（ASIA）标准评价患者治疗前、后神经功能，卡氏评分评估患者治疗前、后身体功能状态。结果 16例患者疼痛明显缓解，VAS评分由治疗前（4.2±2.1）分下降至治疗后1个月（2.1±1.3）分，卡氏评分由治疗前（66.25±16.28）分提高至治疗后3个月时的（74.69±17.56）分，差异均有统计学意义（P＜0.05）。神经功能保留率和恢复率分别为81.3%和50.0%。治疗后随访1～20个月，全组中位生存时间10个月。随访期间均未出现严重并发症。结论 125I放射性粒子组织间植入治疗MESCC可缩小肿瘤体积，减轻患者疼痛，改善患者生活质量和生存时间，是一种可选择的姑息性治疗方法。

参考文献/References:

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备注/Memo

备注/Memo:
（收稿日期：２０１4-12-０2）
（本文编辑：俞瑞纲）
更新日期/Last Update: 2015-08-23