[1]翁文采,张文俊,王 峰,等.动脉灌注3-溴丙酮酸对兔移植性直肠肿瘤的作用[J].介入放射学杂志,2015,(07):616-620.
 WENG Wen-cai,ZHANG Wen-jun,WANG Feng,et al.Effect of arterial perfusion of 3-bromopyruvate on transplanted rectal tumors: an experimental study in rabbits[J].journal interventional radiology,2015,(07):616-620.
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动脉灌注3-溴丙酮酸对兔移植性直肠肿瘤的作用 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年07期
页码:
616-620
栏目:
实验研究
出版日期:
2015-07-25

文章信息/Info

Title:
Effect of arterial perfusion of 3-bromopyruvate on transplanted rectal tumors: an experimental study in rabbits
作者:
翁文采 张文俊 王 峰 梁文波 高宏波 李成刚 艾 琦 宋吉慧
Author(s):
WENG Wen-cai ZHANG Wen-jun WANG Feng LIANG Wen-bo GAO Hong-bo LI Cheng-gang AI Qi SONG Ji-hui
Department of Interventional Radiology,Affiliated Xinhua Hospital, Dalian University, Dalian, Liaoning Province 116021, China
关键词:
【关键词】 3-溴丙酮酸 移植性动物模型 直肠肿瘤 动脉灌注
文献标志码:
A
摘要:
【摘要】 目的 观察动脉灌注3-溴丙酮酸(3-BrPA)对兔移植性直肠肿瘤的作用效果。方法 将60只移植有直肠肿瘤的新西兰大白兔随机分为低、中、高剂量治疗组及生理盐水对照组,每组各15只。对低、中、高剂量组实验兔分别经导管于肠系膜后动脉灌注0.5 mmol/L、1.0 mmol/L、2.0 mmol/L浓度的3-BrPA各10 ml;对照组灌注等量生理盐水。4 d后活体解剖取出直肠肿瘤,镜下观察肿瘤细胞坏死程度并计算坏死率,评估各浓度3-BrPA对肿瘤的作用效果。结果 60只实验兔完成直肠肿瘤移植、动脉灌注实验,镜下实验兔肿瘤细胞均有不同程度损坏。低剂量组Ⅰ级坏死3只,Ⅱ级坏死11只,Ⅲ级坏死1只,治疗有效率为6.7%;中剂量组Ⅱ级坏死2只,Ⅲ级坏死10只,Ⅳ级坏死3只,治疗有效率为86.6%;高剂量组Ⅲ级坏死2只,Ⅳ级坏死13只,治疗有效率为100%;对照组Ⅰ级坏死15只。中、高剂量组Ⅲ、Ⅳ级肿瘤坏死率、治疗有效率、4级肿瘤坏死水平比较差异有统计学意义(P<0.05),3-BrPA治疗作用明显,而正常肠组织无损伤。结论 动脉灌注3-BrPA治疗兔移植性直肠肿瘤有一定疗效,高浓度剂量组肿瘤坏死率和治疗有效率最高,疗效显著。     

参考文献/References:

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备注/Memo

备注/Memo:
(收稿日期:2014-11-05)
(本文编辑:边 佶)
更新日期/Last Update: 2015-07-22