[1]黄文军,闫博宇,叶君明,等.缺血后适应对急性心肌梗死急症介入治疗 患者心肌灌注及预后的影响[J].介入放射学杂志,2015,(07):571-574.
 HUANG Wen- jun,YAN Bo- yu,YE Jun- ming,et al.Effects of ischemic postconditioning on myocardial perfusion and prognosis in patients with acute myocardial infarction treated with emergency percutaneous coronary intervention[J].journal interventional radiology,2015,(07):571-574.
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缺血后适应对急性心肌梗死急症介入治疗    患者心肌灌注及预后的影响 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年07期
页码:
571-574
栏目:
心脏介入
出版日期:
2015-07-25

文章信息/Info

Title:
Effects of ischemic postconditioning on myocardial perfusion and prognosis in patients with acute myocardial infarction treated with emergency percutaneous coronary intervention
作者:
黄文军 闫博宇 叶君明 周国忠 荣德爱 李 莺
Author(s):
HUANG Wen- jun YAN Bo- yu YE Jun- ming ZHOU Guo- zhong RONG De- ai LI Ying
Department of Cardiology, Pingxiang Municipal People’s Hospital, Pingxiang, Jiangxi Province 337055, China
关键词:
【关键词】 急性心肌梗死 经皮冠状动脉介入 缺血后适应 主要心血管事件
文献标志码:
A
摘要:
【摘要】 目的 探讨缺血后适应(IPOC)对急性ST段抬高型心肌梗死(STEMI)急症经皮冠状动脉介入治疗(PCI)患者心肌灌注和预后的影响。方法 203例接受急症PCI 治疗的STEMI患者随机分为IPOC组(n=103)和对照组(n=100),IPOC组在再灌注开始1 min内行IPOC处理,对照组在再灌注后最初6 min内不作干预。观察两组患者心肌肌钙蛋白I(cTnI)峰值、肌酸激酶同工酶(CK?蛳 MB)峰值、左室射血分数(LVEF)、室壁运动评分指数(WMSI)、校正的TIMI计帧(CTFC)及住院期间主要心血管不良事件(MACE)有无差异。结果 两组患者在年龄、性别、危险因素、梗死相关血管、缺血时间等方面差异均无统计学意义(P>0.05);IPOC组CTFC明显快于对照组[(25.3±7.9)帧对(29.4±8.4)帧(P<0.05)];IPOC组CK?蛳 MB峰值、cTnI峰值明显低于对照组[(157.3±83.6) U/L对(201.5±77.3) U/L,(2.5±1.3) ng/ml对(3.1±1.0) ng/ml)(P<0.05)];两组患者入院时LVEF、WMSI均无统计学差异,术后3个月IPOC组LVEF、WMSI均明显优于对照组[(57.4±8.7)%对(53.6±9.3)%,1.19±0.4对1.27±0.3(P<0.05)]。IPOC组术后3个月MACE发生率明显低于对照组(P<0.05)。结论 IPOC能够改善STEMI急症PCI 治疗患者冠状动脉血流,减轻心肌细胞缺血-再灌注损伤,改善心功能及预后。

参考文献/References:

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备注/Memo

备注/Memo:
(收稿日期:2014-10-07)
(本文编辑:边 佶)
更新日期/Last Update: 2015-07-22