[1]王 珏,赵玉武,朱悦琦,等.颈动脉分叉部动脉瘤模型的建立[J].介入放射学杂志,2015,(03):231-235.
 WANG Jue,ZHAO Yu wu,ZHU Yue qi,et al.The establishment of aneurysm model at the carotid artery bifurcation in experimental dogs[J].journal interventional radiology,2015,(03):231-235.
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颈动脉分叉部动脉瘤模型的建立 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年03期
页码:
231-235
栏目:
实验研究
出版日期:
2015-03-25

文章信息/Info

Title:
The establishment of aneurysm model at the carotid artery bifurcation in experimental dogs
作者:
王 珏 赵玉武 朱悦琦 李 菁
Author(s):
WANG Jue ZHAO Yu wu ZHU Yue qi LI Jing.
School of Medicine, Soochow University, Suzhou, Jiangsu Province 215123, China
关键词:
【关键词】 动脉瘤 动物模型 颈动脉
文献标志码:
A
摘要:

【摘要】 目的 探讨建立犬颈动脉分叉部动脉瘤模型的可行性。方法 建立18只犬新的颈总动脉(CCA)分叉部动脉瘤模型,随机分为分叉部顶端弹性蛋白酶处理组(实验组,n = 9)和生理盐水处理组(对照组,n = 9)。术后即刻、12周和24周分别行血管造影观察动脉瘤顶端形态变化,术后12周和24周分别行组织病理学分析。结果 血管造影显示实验组中5只模型动脉分叉顶部观察到新生动脉瘤形成,平均直径(3.2 ± 0.4)mm,对照组中所有模型分叉部顶端均未观察到有新生动脉瘤形成。实验组中新生动脉瘤在随访过程中未见到动脉瘤破裂。组织病理学分析显示实验组中分叉部顶端动脉瘤表现为内弹力膜不连续、弹力纤维断裂、肌层变薄、平滑肌细胞减少(与对照组相比,P < 0.001)。结论 犬重建颈动脉分叉顶端经弹力酶消化所致动脉壁退化可引起新生动脉瘤形成。

 

参考文献/References:

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备注/Memo

备注/Memo:
(收稿日期:2014-09-22)
(本文编辑:边 佶)
更新日期/Last Update: 2015-03-29