[1]张玉锋.肠系膜上动脉灌注化疗治疗大网膜转移癌所致肠梗阻的疗效观察[J].介入放射学杂志,2015,(02):130-133.
 ZHANG Yu feng..Therapeutic efficacy of superior mesenteric arterial infusion chemotherapy for bowel obstruction caused by metastatic carcinoma of greater omentum[J].journal interventional radiology,2015,(02):130-133.
点击复制

肠系膜上动脉灌注化疗治疗大网膜转移癌所致肠梗阻的疗效观察 ()

PDF下载中关闭

分享到:

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年02期
页码:
130-133
栏目:
肿瘤介入
出版日期:
2015-02-25

文章信息/Info

Title:
Therapeutic efficacy of superior mesenteric arterial infusion chemotherapy for bowel obstruction caused by metastatic carcinoma of greater omentum
作者:
张玉锋
Author(s):
ZHANG Yu feng.
Section II, Department of Oncology, Renhe Hospital, Beijing 102600, China
关键词:
【关键词】 动脉灌注化疗 肠系膜上动脉 大网膜转移癌 恶性肠梗阻
文献标志码:
A
摘要:
【摘要】 目的 探讨肠系膜上动脉灌注化疗治疗大网膜转移癌所致肠梗阻的治疗效果,为临床治疗恶性肠梗阻提供参考。方法 115例因大网膜转移癌患者存在腹痛、腹胀、无排气排便伴或不伴有恶心、呕吐等肠梗阻症状、腹部增强CT明确腹膜转移结节、腹部立位X线平片证实存在肠管扩张、肠内积气伴或不伴有液平等肠梗阻表现、腹部彩色多普勒超声明确腹水情况,随机分为动脉灌注化疗组58例和对照组57例,分别行肠系膜上动脉灌注化疗和内科姑息治疗。比较两组肠梗阻缓解时间、腹水消退情况、治疗效果及患者生存时间,并观察肠系膜上动脉灌注化疗的不良反应。结果 动脉灌注化疗组患者腹胀及腹痛缓解时间、恢复排气时间及恢复排便时间均显著短于对照组(t = 3.22、5.60、3.81,P < 0.05),肠道通畅维持时间较对照组显著延长(t = 9.05,P < 0.01),腹水改善情况(75.0%)明显较对照组(33.3%)好(χ2 = 11.35,P < 0.01)。动脉灌注化疗组肠梗阻治疗有效率为82.8%,显著高于对照组的42.1%(χ2 = 14.55,P < 0.01);动脉灌注化疗组生存时间(5.3 ± 1.2)个月,较对照组的(2.8 ± 0.9)个月显著延长(P < 0.01)。动脉灌注化疗组27例(46.6%)发生腹泻,血液系统及肝肾功能损害较小。结论 采用肠系膜上动脉灌注化疗治疗大网膜转移癌所致肠梗阻疗效较好,能够在短期内缓解肠梗阻症状,不良反应少,可以延长患者的生存期。

参考文献/References:

[1] Nissan A, Stojadinovic A, Garofalo A, et al. Evidence based medicine in the treatment of peritoneal carcinomatosis: Past, present, and future[J]. J Surg Oncol, 2009, 100: 335 344.
[2] Krouse RS. Surgical management of malignant bowel obstruction[J]. Surg Oncol Clin N Am, 2004, 13: 479 490.
[3] Idelevich E, Kashtan H, Mavor E, et al. Small bowel obstruction caused by secondary tumors[J]. Surg Oncol, 2006, 15: 29 32.
[4] Ripamonti C, Bruera E. Palliative management of malignant bowel obstruction[J]. Int J Gynecol Cancer, 2002, 12: 135 143.
[5] Ueshima Y, Taniguchi H, Miyata K, et al. Superior mesenteric arterial infusion chemotherapy in patient with both peritoneal carcinomatosis and liver metastasis[J]. Gan To Kagaku Ryoho, 1992, 19: 1731 1733.
[6] 万德森, 潘志忠. 大肠癌[M]. 北京: 中国医药科技出版社, 2004: 430.
[7] 于世英, 王杰军, 王金万, 等. 晚期癌症患者合并肠梗阻治疗的专家共识[J]. 中华肿瘤杂志, 2007, 29: 637 640.
[8] Pameijer CR, Mahvi DM, Stewart JA, et al. Bowel obstruction in patients with metastatic cancer: does intervention influence outcome?[J]. Int J Gastrointest Cancer, 2005, 35: 127 133.
[9] 吴铁成, 邵永孚. 恶性肠梗阻诊治进展[J]. 国际外科学杂志, 2007, 34: 658 659.

相似文献/References:

[1]王兴华,朱汉洲,李立.腹部手术后消化道出血的介入诊断与治疗[J].介入放射学杂志,2000,(04):240.
[2]张大海.胰周血管的螺旋CT血管造影[J].介入放射学杂志,1998,(03):130.
[3]陆永,季博青,尚克中,等.腹部大血管多发性栓塞经导管尿激酶溶栓治疗一例[J].介入放射学杂志,1992,(01):56.
[4]张一平,许绍雄,尚国燕,等.华蟾素联合化疗药物经动脉灌注栓塞治疗原发性肝癌的临床研究[J].介入放射学杂志,1996,(01):42.
[5]黄坤林,刘玉金.紫杉醇- 顺铂方案经导管动脉灌注化疗治疗不可切除非小细胞肺癌的临床应用[J].介入放射学杂志,2020,29(06):612.
 HUANG Kunlin,LIU Yujin..The clinical application of transcatheter arterial infusion chemotherapy with TP regimen in treating unresectable non- small cell lung cancer[J].journal interventional radiology,2020,29(02):612.

备注/Memo

备注/Memo:
(收稿日期:2014-04-24)
(本文编辑:俞瑞纲)
更新日期/Last Update: 2015-02-16