[1]曾江正,刘光清,郝新宝,等. 冷循环射频消融治疗后肝癌患者调节性T细胞变化及其对预后的影响[J].介入放射学杂志,2014,(06):491-495.
　ZENG Jiang- zheng,LIU Guang- qing,HAO Xin- bao,et al. Changes of regulatory T cells in patients with hepatocellular carcinoma after percutaneous cool- tip radiofrequency ablation and its influence on the prognosis[J].journal interventional radiology,2014,(06):491-495.
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 冷循环射频消融治疗后肝癌患者调节性T细胞变化及其对预后的影响()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2014年06期
页码:
491-495
栏目:
非血管介入
出版日期:
2014-07-05

文章信息/Info

Title:
 Changes of regulatory T cells in patients with hepatocellular carcinoma after percutaneous cool- tip radiofrequency ablation and its influence on the prognosis
作者:
 曾江正;  刘光清;  郝新宝;  洪 涛;  张建辉;  苏群豪;  黄美珠;  黄 芬;  雷俊华
Author(s):
 ZENG Jiang- zheng;  LIU Guang- qing;  HAO Xin- bao;  HONG Tao;  ZHANG Jian- hui;  SU Qun- hao;  HUANG Mei- zhu;  HUANG Fen;  LEI Jun- hua.
 Department of Oncology， Tumor Institute， Affiliated Hospital of Hainan Medical College， Haikou， Hainan Province 570102， China
关键词:
 ; 【关键词】 冷循环电极;  射频消融;  肝癌;  调节性T细胞;  受试者工作特征曲线
文献标志码:
A
摘要:
 【摘要】 目的 探讨冷循环射频消融（RFA）治疗对肝癌（HCC）患者调节性T细胞（Treg）变化及其对预后的影响。方法 流式细胞仪检测冷循环RFA治疗前，治疗后1、4、7和12个月后外周血Treg的变化。随访期间采用超声造影或肝脏增强CT评估疗效。采用受试者工作特征（ROC）曲线及Kaplan?蛳 Meier生存函数的方法分析Treg动态变化与肿瘤无进展生存期的关系。结果 RFA术后1个月，30例患者肿瘤缓解（TR）率93.3%（28/30），肿瘤进展（TP）率6.67%（2/30）。RFA术前Treg（9.42 ± 1.16）%，术后1个月（6.55 ± 0.97）%，较术前显著下降（t = 15.325，P ＜ 0.01）。经12个月随访，TR率33.3%（10/30），TP率66.7%（20/30）。TR组术前Treg为（8.75 ± 0.72）%，显著低于TP组（9.76 ± 1.20）%（t = -2.448，P = 0.021）。ROC曲线表明Treg谷值以4.82%为最佳临界值时，灵敏度为90.0%，特异度为60.0%；Treg达谷时间以5.5个月为最佳临界值，灵敏度为70.0%，特异度为85.0%。采用Kaplan?蛳 Meier曲线分析表明，肝癌RFA术后Treg谷值 ≤ 4.82%的肿瘤无进展生存率优于Treg谷值 ＞ 4.82%的患者；Treg达谷时间 ≥ 5.5个月的患者预后优于Treg达谷时间 ＜ 5.5个月的患者，Log?蛳 rank检验分别为?字2 = 5.207，P = 0.023；?字2 = 22.079，P ＜ 0.01。结论 冷循环RFA可以下调Treg水平，并且Treg谷值及Treg达谷时间在一定程度上反映RFA治疗HCC患者的预后。

参考文献/References:

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备注/Memo

备注/Memo:
 （收稿日期：２０１3-11-28）
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