[1]胡继红,赵学凌,李宏昆,等.TGF)、- β1、Serpine1、vWF、PF4在深静脉血栓患者血白细胞和血小板中的表达[J].介入放射学杂志,2013,(03):185-189.
HU Ji? hong,ZHAO Xue? ling,LI Hong? kun,et al.The TGF-β1, serpine1, vHF and PF4 expression of leucocytes and platelets in patients with deep vein thrombosis[J].journal interventional radiology,2013,(03):185-189.
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TGF)、- β1、Serpine1、vWF、PF4在深静脉血栓患者血白细胞和血小板中的表达()
《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]
- 卷:
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- 期数:
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2013年03期
- 页码:
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185-189
- 栏目:
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血管介入
- 出版日期:
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2013-03-25
文章信息/Info
- Title:
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The TGF-β1, serpine1, vHF and PF4 expression of leucocytes and platelets in patients with deep vein thrombosis
- 作者:
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胡继红; 赵学凌; 李宏昆; 吴雪梅; 王 兵
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- Author(s):
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HU Ji?蛳 hong; ZHAO Xue?蛳 ling; LI Hong?蛳 kun; WU Xue?蛳 mei; WANG Bing.
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Department of Radiology and Department of Orthopaedics, the First Affiliated Hospital of Kunming Medical College, Kunming, Yunnan Province 650032, China.
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- 关键词:
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【关键词】 深静脉血栓; 转化生长因子-β1; 纤溶酶原激活物抑制因子1; 血管性血友病因子; 血小板第4因子
- 文献标志码:
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A
- 摘要:
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【摘要】 目的 研究转化生长因子(TGF)- β1、纤溶酶原激活物抑制因子1(Serpine1)、血管性血友病因子(vWF)、血小板第4因子(PF4) mRNA在深静脉血栓患者血白细胞和血小板中的表达变化及在血栓形成中的作用。方法 将患者分为血栓形成组15例和无血栓形成组15例,另选正常对照组15例。采集患者血栓形成和不形成时相应状态的血液样本,提取血白细胞和血小板中总RNA,并反转录为cDNA,采用PCR和实时-PCR技术,检测TGF?蛳 β1、Serpine1、vWF、PF4 mRNA在各组中的表达。结果 PCR和实时-PCR的检测结果一致,TGF?蛳 β1、Serpine1、vWF、PF4 mRNA在血栓形成组中的表达明显高于无血栓形成组和正常对照组(P < 0.05),而在无血栓形成组和正常对照组间则差异无统计学意义(P > 0.05)。结论血白细胞和血小板中TGF?蛳 β1、Serpine1、vWF、PF4 mRNA表达上调可能在深静脉血栓形成中发挥了重要作用。
参考文献/References:
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备注/Memo
- 备注/Memo:
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(收稿日期:2013-01-12)
更新日期/Last Update: