[1]胡 萍,司同国,郭 志.血清高迁移率族蛋白B1检测在T3N0M0期前列腺癌冷冻治疗后复发中的意义[J].介入放射学杂志,2013,(04):298-300.
　HU Ping,SI Tong? guo,GUO Zhi..The significance of serum HMGB1 in forecasting the recurrence of stage T3N0M0 prostate cancer after cryotherapy[J].journal interventional radiology,2013,(04):298-300.
点击复制

血清高迁移率族蛋白B1检测在T3N0M0期前列腺癌冷冻治疗后复发中的意义()

PDF下载中关闭

分享到：

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2013年04期
页码:
298-300
栏目:
肿瘤介入
出版日期:
2013-04-17

文章信息/Info

Title:
The significance of serum HMGB1 in forecasting the recurrence of stage T3N0M0 prostate cancer after cryotherapy
作者:
胡 萍;  司同国;  郭 志
Author(s):
HU Ping;  SI Tong?蛳 guo;  GUO Zhi.
Department of Interventional Therapy， Affiliated Tumor Hospital of Tianjin Medical University， Tianjin Municipal Key Laboratory of Cancer Prevention and Treatment， Tianjin 300060， China
关键词:
【关键词】 前列腺癌;  复发;  转移;  高迁移率族蛋白B1;  肿瘤标记
文献标志码:
A
摘要:
【摘要】 目的 探讨血清高迁移率族蛋白B1（HMGB1）预测T3N0M0期前列腺癌冷冻治疗后复发的临床意义。方法 收集65例T3期前列腺癌患者（PCa组）和30例前列腺良性增生患者（BPH组）的血清样本，应用酶联免疫吸附试验测定血清HMGB1水平；PCa组患者均行经皮穿刺冷冻消融治疗，术后随访外周血前列腺特异抗原（PSA）、前列腺MRI，可疑复发者行病理穿刺活检证实。比较PCa组患者血清HMGB1水平。结果 术前血清HMGB1在PCa组为（55.28 ± 29.37）ng/ml，明显高于BPH组的（34.61 ± 13.15）ng/ml（P = 0.004）。PCa组患者冷冻治疗后，无复发46例，局部复发15例，远处转移4例，三者术前HMGB1平均值分别为（55.49 ± 7.12）ng/ml、（73.13 ± 7.89）ng/ml和（94.23 ± 17.91）ng/ml，差异有统计学意义（P < 0.01）。结论 术前血清HMGB1水平高的PCa患者冷冻治疗后复发、转移率较高，血清HMGB1的检测可为冷冻治疗后复发性前列腺癌的诊断提供重要临床价值。

参考文献/References:

［1］ Tanaka N， Fujimoto K， Hirayama A， et al. Trends of the primary therapy for patients with prostate Cancer in Nara uro?蛳 oncological research group （NUORG）： a comparison between the CaPSURE data and the NUORG data［J］. Jpn J Clin Oncol， 2010， 40： 588 ?蛳 592.［2］ Lian H， Guo H， Gan W， et al. Cryosurgery as primary treatment for localized prostate Cancer［J］. Int Urol Nephrol， 2011， 43： 1089 ?蛳 1094.［3］ Ishiguro H， Nakaigawa N， Miyoshi Y， et al. Receptor for advanced glycation end products （RAGE） and its ligand， amphoterin are overexpressed and associated with prostate Cancer development［J］. Prostate， 2005， 64： 92 ?蛳 100.［4］ 郭 志． 关注冷冻消融治疗前列腺癌的若干问题［J］． 中华医学杂志， 2010， 84： 2959 ?蛳 2961．［5］ 郭 志， 王海涛， 邢文阁， 等． 冷冻消融治疗T3N0M0期前列腺癌的初步临床观察［J］． 中华医学杂志， 2004， 90： 2815 ?蛳 2819．［6］ 朱 刚， 刘 明， 万 奔， 等. 早期前列腺癌的诊断和治疗［J］． 中华男科学杂志， 2005， 11： 693 ?蛳 696.［7］ Kuban DA， Levy LB， Potters L， et al. Comparison of biochemi?蛳 cal failure definitions for permanent prostate brachytherapy［J］. Int J Radiat Oncol Biol Phys， 2006， 65： 1487 ?蛳 1493.［8］ Kuniyasu H， Chihara Y， Kondo H， et al. Amphoterin induction in prostatic stromal cells by androgen deprivation is associated with metastatic prostate Cancer［J］. Oncol Rep， 2003， 10： 1863 ?蛳 1868.［9］ Chen J， Liu X， Zhang J， et al. Targeting HMGB1 inhibits ovarian Cancer growth and metastasis by lentivirus?蛳 mediated RNA interference［J］ J Cell Physiol， 2012， 227： 3629 ?蛳 3638.［10］ Lee H， Song M， Shin N， et al. Diagnostic significance of serum HMGB1 in colorectal carcinomas［J］. PLoS One， 2012， 7： e34318.［11］ Li T， Gui Y， Yuan T， et al. Overexpression of high mobility group box 1 with poor prognosis in patients after radical prostatectomy［J］. BJU Int， 2012， 110： e1125 ?蛳 1130.

相似文献/References:

[1]杨熙章,吴纪瑞,杨永岩,等.灌注化疗预防肝癌术后复发[J].介入放射学杂志,1999,(02):32.
[2]许晓泉,施海彬,刘　　　圣,等. 外伤性颈动脉海绵窦瘘球囊栓塞术后复发危险因素分析及治疗[J].介入放射学杂志,2011,(12):931.
　XU Xiao-quan,SHI Hai-bin,LIU Sheng,et al.The analysis of risk factors and the treatment of recurrent traumatic carotid cavernous fistulas previously managed with detachable balloons[J].journal interventional radiology,2011,(04):931.
[3]顾俊鹏,顾 朋,迪力木拉提?巴吾东,等. 大咯血的介入治疗及复发的影响因素分析[J].介入放射学杂志,2012,(11):952.
　GU Jun? peng,GU Peng,DilimulatiBawudong,et al. The interventional management of massive hemoptysis and the analysis of factors influencing its recurrence[J].journal interventional radiology,2012,(04):952.
[4]宋国平,程英升.MR多序列成像对前列腺癌穿刺活检及重复活检的指导价值[J].介入放射学杂志,2013,(07):605.
　SONG Guo? ping,CHENG Ying? sheng. a.The guiding value of multi?蛳 sequence MRI in performing biopsy and repeated biopsy of the prostate cancer[J].journal interventional radiology,2013,(04):605.
[5]徐国斌,易广新,熊斌,等.原发性肝癌术后早期肝内复发转移36例的介入治疗[J].介入放射学杂志,2013,(04):325.
　XU Guo? bin,YI Guang? xin,XIONG Bin,et al.Interventional treatment of early intrahepatic recurrence or metastasis of primary liver carcinoma after surgical resection： initial experience of 36 cases[J].journal interventional radiology,2013,(04):325.
[6]任国荣,姜 平,曹枭强,等. 基于CT的三维颈内动脉瘤手术前后的血流动力学分析[J].介入放射学杂志,2013,(10):825.
　REN Guo? rong,JIANG Ping,CAO Xiao? qiang,et al. Hemodynamic analysis of preoperative and postoperative carotid aneurysm by using CT 3- D numerical simulation[J].journal interventional radiology,2013,(04):825.
[7]宗迎迎,徐 浩,许 伟,等.经肝动脉化疗栓塞联合经皮微波消融序贯治疗早期肝癌的疗效及预后影响因素[J].介入放射学杂志,2015,(03):210.
　ZONG Ying ying,XU Hao,XU Wei,et al.Sequential therapy of TACE followed by percutaneous microwave coagulation for early stage primary hepatocellular carcinomas： curative effect and prognostic factors[J].journal interventional radiology,2015,(04):210.
[8]任 炜,杨 薇.射频消融治疗复发性肝癌疗效及预后因素分析[J].介入放射学杂志,2015,(10):923.
　REN Wei,YANG Wei.Radiofrequency ablation for the treatment of recurrent hepatocellular carcinoma： analysis of the therapeutic results and prognostic factors[J].journal interventional radiology,2015,(04):923.
[9]徐中琪,甘 伟,钱国军.复发性肝内胆管细胞癌治疗现状[J].介入放射学杂志,2016,(09):834.
　XU Zhong- qi,GAN Wei,QIAN Guo- jun.The treatment of recurrent intrahepatic cholangiocarcinomas： its present situation[J].journal interventional radiology,2016,(04):834.
[10]徐中琪,甘 伟,刘 晟,等.经皮热消融治疗术后复发型肝内胆管细胞癌疗效分析[J].介入放射学杂志,2016,(11):973.
　XU Zhong- qi,GAN Wei,LIU Sheng,et al.Percutaneous thermal ablation for the treatment of recurrent intrahepatic cholangio carcinoma： analysis of curative effect[J].journal interventional radiology,2016,(04):973.

备注/Memo

备注/Memo:
（收稿日期：２０１2-11-12）
更新日期/Last Update: