[1]陈少伯,赵季红,梁国庆,等.光学相干断层显像联合血流储备分数在冠状动脉临界病变中的应用[J].介入放射学杂志,2013,(03):177-180.
 CHEN Shao? bo,ZHAO Ji? hong,LIANG Guo? qing,et al.The application of optical coherence tomography combined with fractional flow reserve in assessing the functional significance of intermediate coronary artery stenosis[J].journal interventional radiology,2013,(03):177-180.
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光学相干断层显像联合血流储备分数在冠状动脉临界病变中的应用()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2013年03期
页码:
177-180
栏目:
心脏介入
出版日期:
2013-03-25

文章信息/Info

Title:
The application of optical coherence tomography combined with fractional flow reserve in assessing the functional significance of intermediate coronary artery stenosis
作者:
陈少伯 赵季红 梁国庆 姜铁民 李玉明
Author(s):
CHEN Shao?蛳 bo ZHAO Ji?蛳 hong LIANG Guo?蛳 qing JIANG Tie?蛳 min LI Yu?蛳 ming.
Cardiology Center, Affiliated Hospital of Armed Police Logistics College, Tianjin 300162, China
关键词:
【关键词】 冠心病 光学相干断层显像 冠状动脉血流储备分数 临界病变
文献标志码:
A
摘要:
【摘要】 目的 在冠状动脉临界病变中,联合应用光学相干断层显像(OCT)和冠状动脉血流储备分数(FFR),分析二者在判断冠状动脉有功能意义缺血上的相关性,探讨OCT指导介入治疗的合理标准。方法 2010年6月至2012年6月收治96例冠状动脉造影管径狭窄率为40% ~ 70%的患者,先后进行FFR和OCT检查,以FFR数值0.75为界,分为FFR正常组(67例)和FFR异常组(29例)。分析两组OCT参数和FFR的相关性。结果 FFR正常组和FFR异常组病变处最小管腔面积分别为(3.45 ± 1.74)mm2和(2.33 ± 1.62)mm2,组间差异有统计学意义(P < 0.01);面积狭窄率分别为(58.44 ± 13.52)%和(65.71 ± 17.16)%,组间差异亦有统计学意义(P < 0.05);脂核面积百分比分别为(23.72 ± 9.26)%和(29.84 ± 12.39)%,组间差异有统计学意义(P < 0.05);最小管腔面积、面积狭窄率和脂核面积百分比与FFR有统计学相关(P < 0.05或 < 0.01)。以最小管腔面积 < 2.3 mm2预测FFR < 0.75的敏感度为92.51%,特异度为78.43%,以面积狭窄率 > 70%预测FFR < 0.75的敏感度为90.64%,特异度为82.35%。以脂核面积百分比大于25%预测FFR < 0.75的敏感度为70.18%,特异度为62.74%。结论 OCT参数(最小管腔面积、面积狭窄率和脂核面积百分比)和FFR有很好的相关性,选取合适的OCT参数指导临界病变介入治疗是可行的。

参考文献/References:

[1] Patil CV, Beyar R. Intermediate coronary artery stenosis: evidence?蛳 based decisions in interventions to avoid the oculostenotic reflex[J]. Int J Cardiovasc Intervent, 2000, 3: 195 ?蛳 206.[2] 姜铁民, 陈少伯, 梁国庆, 等. OCT和IVUS在冠状动脉病变诊断中的对比研究[J]. 天津医药, 2007, 35: 338 ?蛳 340.[3] Ben?蛳 Dor I, Torguson R, Deksissa T, et al. Intravascular ultrasound lumen area parameters for assessment of physiological ischemia by fractional flow reserve in intermediate coronary artery stenosis[J]. Cardiovasc Revasc Med, 2012, 13: 177 ?蛳 182.[4] Pijls NH, Van Gelder B, Van der Voort P, et al. Fractional flow reserve. A useful index to evaluate the influence of an epicardial coronary stenosis on myocardial blood flow[J]. Circulation, 1995, 92: 3183 ?蛳 3193.[5] Pijls NH, De Bruyne B, Peels K, et al. Measurement of fractional flow reserve to assess the functional severity of coronary?蛳 artery stenoses[J]. N Engl J Med, 1996, 334: 1703 ?蛳 1708.[6] Trana C, Muller O, Eeckhout E. Coronary artery disease diagnostic with fractional flow reserve[J]. Rev Med Suisse, 2011, 7: 1182 ?蛳 1188.[7] 陈少伯, 梁国庆, 姜铁民, 等. OCT在冠心病介入治疗中应用的研究进展[J]. 武警医学院学报, 2008, 17: 921 ?蛳 923.[8] Karanasos A, Ligthart J, Witberg K, et al. Optical coherence tomography: potential clinical applications[J]. Curr Cardiovasc Imaging Rep, 2012, 5: 206 ?蛳 220.[9] Gonzalo N, Gonzalo N, Escaned J, et al. Morphometric assess?蛳 ment of coronary stenosis relevance with optical coherence tomography: a comparison with fractional flow reserve and intra?蛳 vascular ultrasound[J]. J Am Coll Cardiol, 2012, 59: 1080 ?蛳 1089.[10] Briguori C, Anzuini A, Airoldi F, et al. Intravascular ultra?蛳 sound criteria for the assessment of the functional significance of intermediate coronary artery stenoses and comparison with fractional flow reserve[J]. Am J Cardiol, 2001, 87: 136 ?蛳 141.[11] Ben?蛳 Dor I, Torguson R, Gaglia MA Jr, et al. Correlation between fractional flow reserve and intravascular ultrasound lumen area in intermediate coronary artery stenosis[J]. Euro?蛳 intervention, 2011, 7: 225 ?蛳 233.

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备注/Memo

备注/Memo:
(收稿日期:2012-08-21)
更新日期/Last Update: