[1]陆 健,王忠敏,陈克敏,等.微正电子发射断层扫描/CT扫描对荷人胰腺癌裸鼠组织间近距离放射治疗的早期疗效评估[J].介入放射学杂志,2012,(07):574-577.
　LU Jian,WANG Zhong- min,CHEN Ke- min,et al. Micro- PET/CT scanning for evaluating early effect of interstitial brachytherapy in treating transplantation tumor of human pancreatic carcinoma in Balb/c nu mice[J].journal interventional radiology,2012,(07):574-577.
点击复制

微正电子发射断层扫描/CT扫描对荷人胰腺癌裸鼠组织间近距离放射治疗的早期疗效评估 ()

PDF下载中关闭

分享到：

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2012年07期
页码:
574-577
栏目:
实验研究
出版日期:
2012-07-30

文章信息/Info

Title:
 Micro- PET/CT scanning for evaluating early effect of interstitial brachytherapy in treating transplantation tumor of human pancreatic carcinoma in Balb/c nu mice
作者:
 陆 健;  王忠敏;  陈克敏;  刘 玉;  郑云峰
Author(s):
 LU Jian;  WANG Zhong- min;  CHEN Ke- min;  LIU Yu;  ZHENG Yun- feng.
 Department of Radiology， Ruijin Hospital Luwan Branch， School of Medicine， Shanghai Jiaotong University， Shanghai 200020， China
关键词:
 ; 【关键词】 胰腺癌;  近距离放射治疗;  氟?蛳 18标记脱氧葡萄糖代谢;  微正电子发射计算机断层扫描
文献标志码:
A
摘要:
 【摘要】 目的 探讨氟?蛳18标记脱氧葡萄糖（18F?蛳 FDG）微正电子发射型计算机断层扫描/CT扫描（Micro?蛳 PET/CT）对125I放射性粒子组织间植入治疗人胰腺癌裸鼠移植瘤模型的评估价值。 方法 将人胰腺癌SW1990细胞株接种于18只BALB/C裸鼠，并将荷瘤裸鼠随机分为空白对照组、空载粒子组和125I粒子植入组，每组6只。分别于治疗前及治疗后1周行18F?蛳 FDG Micro?蛳 PET/CT检查，计算最大标准摄取值（SUVmax）、平均标准摄取值（SUVmean）。瘤体标本进行胸苷激酶1（TK1）检测细胞增殖及末端脱氧核苷酸转移酶-生物素dUTP切口末端标记法（TUNEL）检测细胞凋亡。 结果 治疗前三组间SUVmax和SUVmean值差异无统计学意义（P > 0.05）。治疗后1周，125I粒子植入组SUVmax和SUVmean分别为0.28 ± 0.20和0.02 ± 0.01，明显低于空白对照组分别为（3.54 ± 1.49和0.59 ± 0.18）和空载粒子组（分别为3.78 ± 1.67和0.57 ± 0.21），三组间SUVmax和SUVmean值差异有统计学意义（P < 0.05）。125I粒子植入组TK1阳性染色指数为37.86 ± 1.71，明显低于空白对照组（64.01 ± 1.48）和空载粒子组（62.88 ± 2.36），差异有统计学意义（P < 0.01）；而125I粒子植入组的凋亡指数为23.78 ± 2.53，明显高于空白对照组（7.99 ± 1.32）和空载粒子组（8.36 ± 1.60），差异亦有统计学意义（P < 0.01）。SUVmax与TK1阳性染色指数呈正相关，而与凋亡指数呈负相关。结论 18F?蛳 FDG Micro?蛳 PET/CT能有效监测胰腺癌近距离放射治疗的疗效，是一个有效的评估手段。

参考文献/References:

［1］   王燕芳， 刘   力， 魏    龙， 等． 小动物正电子断层扫描仪（Micro?蛳PET）技术概述［J］． 中国体视学与图像分析， 2005， 10： 174 ?蛳 175．
［2］   Eisenhauer EA， Therasse P， Bogaerts J， et al. New response evaluation criteria in solid tumours： revised RECIST guideline （version 1.1）［J］. Eur J Cancer， 2009， 45： 228 ?蛳 247.
［3］   Chatziioannou AF. PET scanners dedicated to molecular imaging of small animal models［J］. Mol Imaging Biol， 2002， 4： 47 ?蛳 63.
［4］   Chatziioannou AF. Molecular imaging of small animals with dedicated PET tomographs［J］. Eur J Nucl Med， 2002， 29： 98 ?蛳 114.
［5］  Wahl RL， Jacene H， Kasamon Y， et al. From RECIST to PERCIST： evolving considerations for PET response criteria in solid tumors［J］. J Nucl Med， 2009， 50 （Suppl 1）： 122S ?蛳 150S.
［6］   Park SS， Chunta JL， Robertson JM， et al. MicroPET/CT imaging of an orthotopic model of human glioblastoma multiforme and evaluation of pulsed low?蛳 dose irradiation［J］. Int J Radiat Oncol Biol Phys， 2011， 80： 885 ?蛳 892.
［7］   Ong LC， Song IC， Jin Y， et al. Effective inhibition of xenografts of hepatocellular carcinoma （HepG2） by rapamycin and bevacizumab in an intrahepatic model［J］. Mol Imaging Biol， 2009， 11： 334 ?蛳 342.
［8］   王忠敏， 黄    钢， 陈克敏， 等． CT引导下125I粒子放射性治疗胰腺癌的疗效观察［J］． 介入放射学杂志， 2009， 18： 668 ?蛳 672．
［9］   陆   健， 郑云峰， 张   欢， 等． CT引导下植入125I粒子治疗19例晚期胰腺癌的疗效观察［J］． 介入放射学杂志， 2010， 19： 550 ?蛳 553．
［10］ Wang ZM，Liu Y， Lin FJ， et al. Clinical efficacy of CT?蛳guided iodine?蛳125 seed implantation therapy in patients with advanced pancreatic Cancer［J］. Eur Radiol， 2010， 20： 1786 ?蛳 1791.
［11］ Kim SY， Yang ES， Lee YS， et al. Sensitive to apoptosis gene protein regulates ionizing radiation?蛳 induced apoptosis［J］. Biochimie， 2011， 93： 269 ?蛳 276.
［12］ Pinthus JH， Bryskin I， Trachtenberg J， et al. Androgen induces adaptation to oxidative stress in prostate Cancer： implications for treatment with radiation therapy［J］. Neoplasia， 2007， 9： 68 ?蛳 80.
［13］ Mao Y， Wu J， Wang N， et al. A comparative study： imm?蛳unohistochemical detection of cytosolic thymidine kinase and proliferating cell nuclear antigen in breast Cancer［J］. Cancer Invest， 2002， 20： 922 ?蛳 931.
［14］ Luo P， Wang N， He E， et al. The proliferation marker thymidine kinase 1 level is high in normal kidney tubule cells compared to other normal and malignant renal cells［J］. Pathol Oncol Res， 2010， 16： 277 ?蛳 283.
［15］ Mao Y， Wu J， Skog S， et al. Expression of cell proliferating genes in patients with non?蛳 small cell lung Cancer by immunohistochemistry and cDNA profiling［J］. Oncol Rep， 2005， 13： 837 ?蛳 846.

相似文献/References:

[1].Spontaneous regression of a giant basilar artery aneurysm in a young adult after surgical injury ：case report and literature review[J].介入放射学杂志,2007,(10):718.
　ZHANG He,LI Ming-hua,WANG Chun,et al.Spontaneous regression of a giant basilar artery aneurysm in a young adult after surgical injury ：case report and literature review[J].journal interventional radiology,2007,(07):718.
[2]李统怀,郑红枫. 子宫动脉栓塞治疗子宫瘢痕妊娠１１例[J].介入放射学杂志,2011,(11):898.
　LI Tong-huai,ZHENG Hong-feng..Clinical application of uterine artery embolization in treating uterine scar pregnancy[J].journal interventional radiology,2011,(07):898.
[3]吕维富,张爱武,周春泽,等. 子宫动脉的三维DSA表现及其最佳显示体位探讨[J].介入放射学杂志,2011,(11):853.
　LV Wei-fu,ZHANG Ai-wu,ZHOU Chun-ze,et al.3D-DSA findings of uterine artery and its optimal projection position[J].journal interventional radiology,2011,(07):853.
[4]张 靖,周少毅,陈昆山,等.经导管动脉硬化栓塞联合注射硬化治疗婴儿颌面部巨大高流量血管瘤[J].介入放射学杂志,2011,(11):848.
　ZHANG Jing,ZHOU Shao-yi,CHEN Kun-shan,et al.Transcatheter arterial sclerosing embolization with injection sclerotherapy for the treatment of huge and high-flow maxillofacial hemangiomas in infants[J].journal interventional radiology,2011,(07):848.
[5]谢小西,吕银祥,章宏欣,等. 肝动脉化疗栓塞、射频消融联合１２５Ⅰ粒子植入 治疗原发性肝癌的临床应用[J].介入放射学杂志,2011,(11):863.
　XIE Xiao-xi,LV Yin-xiang,ZHANG Hong-xin,et al.The clinical application of TACE together with RFA and 125Ⅰ seed implantation in treating hepatocellular carcinoma[J].journal interventional radiology,2011,(07):863.
[6]王铭义,王 峰. 脑灌注成像在颈动脉狭窄介入治疗中的应用[J].介入放射学杂志,2011,(11):915.
　WANG Ming-yi,WANG Feng..Application of brain perfusion imaging in interventional treatment of carotid artery stenosis[J].journal interventional radiology,2011,(07):915.
[7]杜 猛,张锦生. 介入治疗急性深静脉血栓的临床观察[J].介入放射学杂志,2011,(11):858.
　DU Meng,ZHANG Jing-sheng..Interventional therapy for acute deep venous thrombosis: a clinical observation[J].journal interventional radiology,2011,(07):858.
[8]孟庆娜,李国庆,白晓冬. 急性心肌梗死介入治疗术中恶心呕吐的护理[J].介入放射学杂志,2011,(11):913.
　MENG Qing-na,LI Guo-qing,BAI Xiao-dong..The nursing care of nausea and vomiting occurred in interventional treatment for acute myocardial infarction[J].journal interventional radiology,2011,(07):913.
[9]王海亭,蒋忠仆,周 毅,等. 透视引导下鱼肝油酸钠泡沫硬化剂治疗下肢静脉曲张３０例[J].介入放射学杂志,2011,(11):905.
　WANG Hai-ting,JIANG Zhong-pu,ZHOU Yi,et al.Fluoroscopically-guided foam sclerotherapy with sodium morrhuate for the treatment of lower extremity varices[J].journal interventional radiology,2011,(07):905.
[10]杜 鲲,管 生,胡小波,等. 原发性肝癌ＴＡＣＥ术后完全缓解病灶磁共振 ＡＤＣ值可重复性及一致性研究[J].介入放射学杂志,2011,(11):867.
　DU Kun,GUAN Sheng,HU Xiao-bo,et al.Magnetic resonance apparent diffusion coefficient values of the completely remitted lesions of primary hepatocellular carcinoma after TACE: a study of their repeatability and consistency[J].journal interventional radiology,2011,(07):867.
[11]中华医学会放射学分会介入学组. 胰腺癌经动脉灌注化疗指南（草案）[J].介入放射学杂志,2012,(05):353.
　,,et al.Ｇｕｉｄｅ ｔｏ ｉｎｔｒａａｒｔｅｒｉａｌ ｉｎｆｕｓｉｏｎ ｃｈｅｍｏｔｈｅｒａｐｙ ｆｏｒ ｐａｎｃｒｅａｔｉｃ ｃａｎｃｅｒｓ （ｄｒａｆｔ ｔｅｘｔ）[J].journal interventional radiology,2012,(07):353.
[12]宋 琦,刘 玉,胡曙东,等.磁共振弥散加权成像在125I粒子组织间植入治疗胰腺癌疗效评估中的应用[J].介入放射学杂志,2012,(06):492.
　SONG Qi,LIU Yu,HU Shu-dong,et al. The application of MR diffusion-weighted imaging in evaluating the efficacy of 125I seed interstitial brachytherapy for pancreatic carcinomas： an experimental study in vivo[J].journal interventional radiology,2012,(07):492.
[13]蒋 奡,王忠敏,张丽云,等. 125I粒子持续照射对Sw1990及Panc?蛳 1细胞 生物学效应的影响[J].介入放射学杂志,2013,(06):490.
　JIANG Ao,WANG Zhong? min,ZHANG Li? yun,et al. The biological effects of continuous 125I seeds irradiation on sw1990 and panc?蛳 1 cells： a comparison study[J].journal interventional radiology,2013,(07):490.
[14]赵晓阳,曹会存,李天晓,等. 经皮肝穿胆道引流术联合125I粒子植入治疗晚期胰腺癌合并梗阻性黄疸[J].介入放射学杂志,2013,(08):650.
　ZHAO Xiao? yang,CAO Hui? cun,LI Tian? xiao,et al. PTCD combined with 125I seed implantation for the treatment of advanced pancreatic cancer associated with obstructive jaundice[J].journal interventional radiology,2013,(07):650.
[15]吴普照,张跃伟. 胰腺癌综合性介入治疗进展[J].介入放射学杂志,2014,(05):452.
　WU Pu- zhao,ZHANG Yue- wei.. Comprehensive interventional therapy for pancreatic cancer： current progress[J].journal interventional radiology,2014,(07):452.

备注/Memo

备注/Memo:
 （收稿日期：2012-02-28）
更新日期/Last Update: