[1]张 磊,顾伟瑾,万军,等.氨甲蝶呤与氟尿嘧啶在介入治疗剖宫产后子宫切口妊娠中的疗效对比[J].介入放射学杂志,2012,(04):327-330.
 ,,et al.The clinical efficacy of methotrexate and 5fluorouracil in the interventional treatment of uterine incisional pregnancy after cesarean section: a comparative study [J].journal interventional radiology,2012,(04):327-330.
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氨甲蝶呤与氟尿嘧啶在介入治疗剖宫产后子宫切口妊娠中的疗效对比 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2012年04期
页码:
327-330
栏目:
临床研究
出版日期:
2012-04-28

文章信息/Info

Title:

The clinical efficacy of methotrexate and 5fluorouracil in the interventional treatment of uterine incisional pregnancy after cesarean section: a comparative study  
作者:
 张 磊顾伟瑾万军纪莉华王海云王 颖季 芳陈 庆
Author(s):
 ZHANG Lei GU Weijin WAN Jun JI Lihua WANG Haiyun WANG Ying JI Fang CHEN Qing.  
 Department of Interventional Radiology, Jing'an Branch of Huashan Hospital, Fudan University, Shanghai 200040, China
关键词:
 【关键词】 切口妊娠 剖宫产 氨甲蝶呤 氟尿嘧啶
文献标志码:
A
摘要:
 【摘要】 目的 比较剖宫产后切口妊娠介入治疗中氨甲蝶呤(MTX)和5氟尿嘧啶(5FU)的疗效。方法 将2007年至2010年收治的92例剖宫产后子宫切口妊娠患者随机分成两组,MTX组46例,给予MTX 60 ~ 200 mg子宫动脉内灌注和灌注后栓塞; 5FU组46例,给予5FU 1 000 ~ 1 250 mg子宫动脉内灌注和灌注后栓塞,比较两种药物对剖宫产后切口妊娠的疗效。介入术后第1、2、3天连续复查患者血β人绒毛膜促性腺激素(βhCG)和孕酮,并随访3个月。结果 MTX组痊愈率97.2%,5FU组痊愈率100%,两组间疗效差异无统计学意义(P > 0.05)。在MTX组和5FU组,分别有40例和38例第 1 ~ 3天血βhCG和孕酮水平迅速下降,下降幅度为50% ~ 80%,两组间差异无统计学意义(P > 0.05)。两组患者均于手术当日出现腹痛,MTX组和5FU组分别有3例和2例术后出现轻度恶心、呕吐,两组间差异无统计学意义(P > 0.05)。术后随访中,两组月经恢复时间、激素水平无显著差别。结论 两种药物在剖宫产后切口妊娠介入治疗中的疗效相似。

参考文献/References:

[1]   谭海平. 子宫切口瘢痕妊娠30 例临床分析[J]. 医学临床研究, 2008, 25: 1457  1458.
[2]  Hung TH, Jeng CJ, Yang YC, et al. Treatment of cervical pregnancy with methotrexate[J]. Int J Gynaecol Obstet, 1996, 53: 243  247.
 [3]  吕美雅.子宫动脉输注甲氨蝶呤加栓塞术治疗子宫疤痕处妊娠〔J〕. 中国计划生育学杂志, 2008, 16: 240  241.
 [4]  Godin PA,Bassil S,Donnez J . An ectopic pregnancy developing in a previous caesarian section scar〔J〕. Fertil Steril 1997 , 67: 398  400.
[5]   顾伟瑾, 王海云, 万   军. 不同剂量MTX经动脉灌注治疗切口妊娠疗效的分析 [J]. 介入放射学杂志, 2010, 19: 568  571.

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备注/Memo

备注/Memo:
(收稿日期:2011-08-16)
更新日期/Last Update: