[1]李彩霞,冯 艳,谷 涛,等.ｐ５３介入治疗对ＶＸ２兔肝癌侵袭转移特性的影响[J].介入放射学杂志,2010,(10):800-804.
　LI Cai-xia,FENG Yan,GU Tao,et al.Effect of interventional treatment with p53 on the invasion and metastasis of VX2 liver tumor in experimental rabbits[J].journal interventional radiology,2010,(10):800-804.
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ｐ５３介入治疗对ＶＸ２兔肝癌侵袭转移特性的影响()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2010年10期
页码:
800-804
栏目:
实验研究
出版日期:
2010-10-30

文章信息/Info

Title:
Effect of interventional treatment with p53 on the invasion and metastasis of VX2 liver tumor in experimental rabbits
作者:
李彩霞; 冯 艳; 谷 涛; 等
250012  济南 山东大学齐鲁医院放射科
Author(s):
LI Cai-xia;  FENG Yan;  GU Tao;  LI Chun-hai.
Department of Radiology, Affiliated Qilu Hospital, Shandong University, Ji’nan 250012, China
关键词:
ｐ５３; 　介入治疗; 　兔; 　ＶＸ２肝癌; 　基质金属蛋白酶２; 　增殖细胞核抗原; 　血管内皮生长因子
分类号:
Ｒ７３－３７
文献标志码:
Ｂ
摘要:
目的　　　探讨ｐ５３介入治疗对ＶＸ２兔肝癌侵袭转移的影响。方法　　　开腹方法将ＶＸ２瘤细胞分别植入４８只新西兰大白兔的肝左叶，建立ＶＸ２兔肝癌模型，随机分为４组（１２只／组），分别进行肝动脉插管介入治疗，对照组注入生理盐水、Ａ组、Ｂ组、Ｃ组分别注入水化碘油、Ａｄｐ５３、Ａｄｐ５３＋水化碘油。术后１周处死肿瘤兔，免疫组化方法测定基质金属蛋白酶２（ＭＭＰ２）、增殖细胞核抗原（ＰＣＮＡ）、血管内皮生长因子（ＶＥＧＦ）表达。结果　　　实验组（Ａ，Ｂ，Ｃ组）观测到肿瘤生长受到明显抑制，与对照组比较差异有统计学意义（Ｐ　＜ ０．０５）。单纯碘油栓塞后，肿瘤区ＭＭＰ２、ＰＣＮＡ表达略有降低，ＶＥＧＦ表达略有升高，与对照组比较差异均无统计学意义（Ｐ　＞ ０．０５）；Ａｄｐ５３组与 Ａｄｐ５３＋水化碘油组的ＭＭＰ２、ＰＣＮＡ及ＶＥＧＦ的表达阳性率降低，与对照组相比差异有统计学意义（Ｐ　＜０．０５）；转移组的ＭＭＰ２、ＰＣＮＡ及ＶＥＧＦ的表达阳性率均高于无转移组（Ｐ　＜　０．０５）；ＭＭＰ２与ＶＥＧＦ及ＰＣＮＡ之间均存在相关性（Ｐ　＜ ０．０５）。结论 ＭＭＰ２、ＶＥＧＦ及ＰＣＮＡ的增高预示着肿瘤高转移、高增殖能力，肿瘤血管高形成能力。Ａｄｐ５３及Ａｄｐ５３＋ 碘油介入治疗可抑制肿瘤的生长，抑制肿瘤新生血管形成，减少转移。

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备注/Memo

备注/Memo:
收稿日期：２０１００３０９
山东省卫生厅资助项目（2001CAICJA12）;山东省自然科学基金Y2007C004
更新日期/Last Update: 2010-10-30