[1]王宏伟,何仕诚,滕皋军,等.经皮椎体成形术治疗椎体转移性肿瘤的疗效分析[J].介入放射学杂志,2010,(10):784-787.
 WANG Hong-wei,HE Shi-cheng,TENG Gao-jun,et al.Percutaneous vertebroplasty for the treatment of spinal metastasis: evaluation of the therapeutic efficacy[J].journal interventional radiology,2010,(10):784-787.
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经皮椎体成形术治疗椎体转移性肿瘤的疗效分析()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2010年10期
页码:
784-787
栏目:
非血管介入
出版日期:
2010-10-30

文章信息/Info

Title:
Percutaneous vertebroplasty for the treatment of spinal metastasis: evaluation of the therapeutic efficacy
作者:
王宏伟何仕诚滕皋军
210009  南京  东南大学医学院医学影像系研究生(王宏伟);东南大学附属中大医院放射科
Author(s):
WANG Hong-wei HE Shi-cheng TENG Gao-jun FANG Wen GUO Jin-he DENG Gang ZHU Guang-yu
Department of Radiology, the Affiliated Zhongda Hospital, Southeast University, Nanjing 21009, China
关键词:
脊柱 转移瘤 椎体成形术 骨水泥
分类号:
R738.1
文献标志码:
摘要:
目的 探讨经皮椎体成形术(PVP)治疗椎体转移性肿瘤的疗效及其影响因素。方法 入住南京东南大学附属中大医院椎体转移性肿瘤患者163例266节椎体采用PVP治疗且随访资料完整,原发癌肿主要为肺癌(42例),肝癌(19例),食管及胃肠癌(34例),肾癌(10例),乳腺癌(46例)等。PVP术后3 d CT复查观察骨水泥分布状况及有无渗漏。按PVP术后24 h,1周,1、3、6和1年以上定期随访评价临床疗效、疼痛复发的原因及观察生存时间。结果 266节椎体PVP操作均成功,138节胸椎骨水泥平均注入量为(3.6 ± 1.5)ml,128节腰椎为(4.5 ± 1.7)ml。平均随访时间(12.0 ± 10.6)个月,术后24 h,1周,1、3、6和12个月有效率分别为87.7%(143/163)、92.6%(151/163)、91.4%(149/163)、84.5%(136/161)、78.3%(108/138)和77.2%(71/92)。术后12个月症状复发39例,复发率23.9%(39/163),包括骨水泥周围癌肿进展6例,其他椎体转移33例。平均生存时间(10.5 ± 10.5)个月,其中乳腺癌与前列腺癌椎体转移54例生存时间为(15.4 ± 11.7)个月,明显长于肺癌、肝癌、胃肠癌及肾癌等105例的生存时间[(8.5±8.1)个月](P < 0.05)。随访期间死亡136例,主要死亡原因为脊椎外原发肿瘤进展及全身多发转移衰竭。CT证实椎旁骨水泥渗漏58例,均无临床症状。结论 PVP治疗椎体转移性肿瘤可迅速缓解疼痛且可保持较长时间稳定;疼痛复发的主要原因是其他椎体新发转移;生存时间与椎体外原发癌肿类型和合并内脏转移密切相关。

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备注/Memo

备注/Memo:
收稿日期 2010-03-16
江苏省科技厅2006年度面上项目(BS2006048)
更新日期/Last Update: 2010-10-30