[1]顾俊,胡伟,肖红兵,等.急性ST段抬高心肌梗死PCI术后替罗非班应用时间对住院期间预后的影响[J].介入放射学杂志,2007,(12):796.
GU Jun,HU Wei,XIAO Hong-bing,et al.Effects of tirofiban application time on in-hospital prognosis in patients with acute ST segment elevation myocardial infarction treated by primary percutaneous coronary intervention[J].journal interventional radiology,2007,(12):796.
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急性ST段抬高心肌梗死PCI术后替罗非班应用时间对住院期间预后的影响()
《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]
- 卷:
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- 期数:
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2007年12期
- 页码:
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796
- 栏目:
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心脏介入
- 出版日期:
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2007-12-15
文章信息/Info
- Title:
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Effects of tirofiban application time on in-hospital prognosis in patients with acute ST segment elevation myocardial infarction treated by primary percutaneous coronary intervention
- 作者:
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顾俊; 胡伟; 肖红兵; 等
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201100上海市闵行区中心医院心内科
- Author(s):
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GU Jun; HU Wei; XIAO Hong-bing; FENG Xiao-di; YU Qiang; JIN Xian; CHEN Cheng-jun; YANG Hui; CHEN Yao-guang; ZHANG Da-dong
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Department of Cardiology,Shanghai Minhang District Central Hospital,Shanghai201100,China
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- 关键词:
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心肌梗塞; 介人治疗; 替罗非班
- 分类号:
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R541.4
- 文献标志码:
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A
- 摘要:
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目的评价急性ST段抬高心肌梗死(STEMI)患者经皮冠状动脉介人治疗(PCI)术后应用替罗非班时间对住院期间预后的影响。方法从2006年1月-2006年12月,50例急性STEMI患者入院后均即刻接受替罗非班治疗,直接PCI治疗后即刻随机分为两组:短时间组(STG29例,PCI术后替罗非班继续使用24~36h)和长时间组(LTG21例,PCI术后替罗非班继续使用48~72h)。记录两组基础临床资料、造影资料、出血事件、住院期间主要心血管事件以及出院前心超评估的左心室射血分数。结果两组间的基础临床状况、造影资料、出血事件发生率差异均无统计学意义(P>0.05);但LTG组的住院期间心绞痛次数较STG组明显减少眼(1.26±0.72)次/d比(1.75±0.88)次/d,P=0.040演,且左心室射血分数明显好于STG组眼(57.2±8.6雪%比穴52.0±8.5雪%;P=0.037演。结论急性STEMI患者急症PCI术后较长时间应用国产替罗非班是安全的,并可减少住院期间心绞痛发作次数以及改善左室射血分数。
参考文献/References:
[1]王乐丰,杨新春,王明生,等.急性心肌梗死行急诊PCI的疗效观察[J].中华心血管病杂志,2002,30:165-168.
[2]Rezkalla SH,Khmer RA.No-reflow phenomenon[J].Circulation,2002,105:656-662.
[3]Montalescot G,Barragan P,Wittenbery O,et al.For the ADMIRAL investigators.Platelet glycopretionⅡb/Ⅲa inhibition with coronary stenting for acute myocardial infarction[J].N Engl J Med,2001,21:1895-1903.
[4]Lee DP,Herity NA,Hiatt BL,et al.Adjunctive platelet glyco-proteinⅡb/Ⅲa inhibition with tirofiban before primary angioplasty improves angiographic outcome:Results of the tirofiban give in the emergency room before primary angioplasty(TIGER-PA)pilot trial[J].Circulation,2003,107:1497-1501.
[5]Brener SJ,Barr LA,Burchenal JE,et al.Randomized,placebo-controlled trial of platelet glycoproteinⅡb/Ⅲa a blockade with primary PTCA Organization and Randomized Trial(RAPPORT)[J].Circulation,1998,98:734-741.
[6]Stone GW,Grines CL,Cox DA,et al.Comparision of angio-plasty with stenting,with or without abeiximab,in acuete myocardial infarction[J].N Engl J Med,2002,346:957-966.
[7]Yang YJ,Zhao JL,You SJ,et al.Different effect of Tirofiban and aspirin plus Clopidogrel on myocardial no-reflow in a mini-swine model of acute myocardial infarction and reperfusion[J].Heart,2006,92:1131-1137.
[8]杨新春,徐立,王乐丰,等.国产替罗非班对急性心肌梗死患者急诊介入治疗术后冠状动脉血流和心肌灌注影响的研究.中国循环杂志,2006,21:4-7.
备注/Memo
- 备注/Memo:
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收稿日期:2007-08-13
更新日期/Last Update:
2007-12-15