[1]朱永强,陈俊英,郭剑峰.ＣＴ引导下１２５Ｉ粒子植入治疗晚期胰腺癌的临床疗效分析[J].介入放射学杂志,2011,(04):283.
　ZHU Yong-qiang,CHEN Jun-ying,GUO Jian-feng.CT-guided 125I seed implantation for the treatment of advanced pancreatic carcinoma: a clinical therapeutic analysis[J].journal interventional radiology,2011,(04):283.
点击复制

ＣＴ引导下１２５Ｉ粒子植入治疗晚期胰腺癌的临床疗效分析()

PDF下载中关闭

分享到：

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2011年04期
页码:
283
栏目:
非血管介入
出版日期:
2011-04-30

文章信息/Info

Title:
CT-guided 125I seed implantation for the treatment of advanced pancreatic carcinoma: a clinical therapeutic analysis
作者:
朱永强;  陈俊英;  郭剑峰
212003  江苏省镇江市中医院介入科
Author(s):
ZHU Yong-qiang;  CHEN Jun-ying;  GUO Jian-feng
Department of Interventional Radiology, Zhenjiang Municipal Hospital of Traditional Chinese Medicine, Zhenjiang 212003, China
关键词:
胰腺癌;  ＣＴ引导;  １２５Ｉ粒子;  组织间植入;  疗效
分类号:
Ｒ７３５.９
摘要:
目的 探讨ＣＴ引导下１２５Ｉ粒子组织间植入治疗晚期胰腺癌的疗效。方法 回顾性分析２００６年６月至２００８年６月１４例无法手术切除的晚期胰腺癌患者，于术前采用治疗计划系统（ＴＰＳ）重建胰腺肿瘤的三维立体图像，通过ＴＰＳ计算出所需粒子数目和总活度，在ＣＴ引导下将１２５Ｉ粒子植入胰腺肿瘤体内。采用的粒子活度为每粒０．５ ～ ０．８ ｍＣｉ，粒子间距为０．６ ～ １．０ ｃｍ，植入时避开血管、胰管以及肠管尤其是结肠等重要脏器，粒子植入后随访时间为２ ～ １８个月。结果 １４例患者粒子植入术后３ ～ ７ ｄ，疼痛开始缓解，术后２个月ＣＴ复查，完全缓解（ＣＲ）１例，部分缓解（ＰＲ）８例，疾病稳定（ＮＣ）３例，疾病进展（ＰＤ）２例，总有效率（ＣＲ　＋　ＰＲ）６４．３％。全组生存时间５　～　１８个月，中位生存时间１０个月。随访中无胰腺炎、胃肠道出血、放射性肠炎等严重并发症。结论　　　１２５Ｉ粒子组织间植入治疗晚期胰腺癌在疼痛缓解方面疗效明确，具有近期疗效好、创伤小、并发症少等优点。

参考文献/References:

[1] Alfieri S, Morganti AG, Giorgio A, et al. Improved survival and local control after intraoperative radiation therapy and postoperative radiotherapy: a multivariate analysis of 46 patients undergoing surgery for pancreatic head cancer[J]. Arch Surg, 2001, 136: 343 - 347.
[2] Cooperman AM, Pancreatic cancer the bigger picture[J]. Surg Clin of North Am, 2001, 81: 557 - 574.
[3] Levin B, Remine WH, Hermann RE, et al. Cancer of the pancreas[J]. Am J Surg, 1978, 135: 185 - 191.
[4] 王俊杰, 修典荣, 冉维强, 等. 术中超声引导放射性Ⅰ粒子植入治疗胰腺癌[J]. 中华放射肿瘤学杂志, 2007, 16: 34 - 37.
[5] 许尔夫. 碘125粒子植入治疗在不能切除的胰腺癌中的应用[J]. 中国现代医生, 2009, 47: 81 - 82.
[6] 王俊杰, 黄 毅, 冉维强. 放射性粒子组织间种植治疗肿瘤近期疗效[J]. 中国微创外科杂志, 2003, 3: 148 - 149.
[7] Shipley WU, Nardi GL, Cohen AM, et a1. Iodine-125 implant and external beam irradiation in patients with localized pancreatic carcinoma:a comparative study to surgical resection[J]. Cancer, 1980, 45: 709 - 714.
[8] Syed AM, Puthawala AA, Neblett DL. Interstitial lodine- I25 implant in the management of unresectable pancreatic carcinoma[J].Cancer, 1983, 52: 808 - 813.
[9] 王忠敏, 陈克敏, 金冶宁, 等. CT引导下植入125Ⅰ粒子放射性粒子治疗胰腺癌的疗效观察[J]. 中国肿瘤临床, 2009, 36: 65 - 69.
[10] Mahnken AH, Ricke J. CT和MR引导下的介入放射学[M]. 李龙,译. 北京: 人民军医出版社, 2010: 84 - 85.
[11] 邵成伟, 田建明, 左长京, 等. CT引导下125Ⅰ放射性粒子植入治疗胰腺癌的疗效评价[J]. 介入放射学杂志, 2007, 12: 825 - 827.

相似文献/References:

[1]刘卫东,苗善巧,李铁钢,等.胰腺癌介入治疗初步经验[J].介入放射学杂志,1997,(03):182.
[2]张大海.胰周血管的螺旋CT血管造影[J].介入放射学杂志,1998,(03):130.
[3]杨宁,刘巍,任安,等.选择性动脉造影与CT检查在胰腺癌术前分期中的作用[J].介入放射学杂志,2000,(01):19.
[4]席名未,谢宗贵,李健,等.经皮穿刺胰管引流及支架置入术在胰腺癌姑息治疗中的应用[J].介入放射学杂志,2007,(05):323.
　XI Ming-wei,XIE Zong-gui,LI Jian,et al.Application of percutaneous pancreatic duct draining and stenting in palliative treatment of pancreatic carcinoma[J].journal interventional radiology,2007,(04):323.
[5]杜学明,许建辉,郎建华,等.多学科技术联合１２５Ⅰ治疗癌梗阻性黄疸[J].介入放射学杂志,2008,(05):346.
　DU Xueming,XU Jianhui,LANG Jianhua,et al.Combination of multi－disciplinary techniques with１２５Ⅰseeds in treating malignant obstructive jaundice[J].journal interventional radiology,2008,(04):346.
[6]王彬,闫东,刘德忠,等.胰腺癌不同治疗模式的疗效分析[J].介入放射学杂志,2008,(06):404.
　WANG Bin,YANG Dong,LIU Dezhong,et al.Analysis of different therapeutic programs for patients with pancreatic carcinoma[J].journal interventional radiology,2008,(04):404.
[7]刘德忠,王彬,闫东,等.胰腺癌综合治疗现状及其价值[J].介入放射学杂志,2008,(06):451.
　LIU Dezhong,WANG Bin,YAN Dong,et al.The current status and evaluation of comprehensive therapy of pancreatic carcinoma[J].journal interventional radiology,2008,(04):451.
[8]李槐,刘德忠,闫东.胰腺癌的介入诊疗[J].介入放射学杂志,2008,(06):381.
　LI Huai,LIU Dezhong,YAN Dong.Interventional therapy for pancreatic carcinoma[J].journal interventional radiology,2008,(04):381.
[9]宋恬,殷士蒙,孙荣跃,等.探讨介入治疗对晚期胰腺癌的疗效[J].介入放射学杂志,2008,(06):411.
　SONG Tian,YIN Shimeng,SUN Rongyue,et al.The efficacy discussion of interventional therapy for advanced pancreatic carcinoma[J].journal interventional radiology,2008,(04):411.
[10]王彬,闫东,刘德忠,等.影响胰腺癌疗效的多因素分析[J].介入放射学杂志,2008,(06):414.
　WANG Bin,YAN Dong,LIU Dezhong,et al.Prognostic factors in patients with pancreatic carcinoma[J].journal interventional radiology,2008,(04):414.

备注/Memo

备注/Memo:
收稿日期２０１０１０１９
更新日期/Last Update: 2011-04-30