[1]庄一平,张 晋,史美祺,等.CT导向肺癌穿刺标本表皮生长因子受体基因突变检测的应用价值[J].介入放射学杂志,2011,(04):276.
 ZHUANG Yi-ping,ZHANG Jin,SHI Mei-qi,et al.Determination of epidermal growth factor receptor gene mutation of lung cancer specimen obtained by CT-guided transthoracic needle aspiration: its clinical value[J].journal interventional radiology,2011,(04):276.
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CT导向肺癌穿刺标本表皮生长因子受体基因突变检测的应用价值()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2011年04期
页码:
276
栏目:
肿瘤介入
出版日期:
2011-04-30

文章信息/Info

Title:
Determination of epidermal growth factor receptor gene mutation of lung cancer specimen obtained by CT-guided transthoracic needle aspiration: its clinical value
作者:
庄一平   张 晋 史美祺   冯   勇   王海彦
210009 南京 江苏省肿瘤医院放射科,内科
Author(s):
ZHUANG Yi-ping ZHANG Jin SHI Mei-qi FENG Yong WANG Hai-yan.
Department of Radiology, Cancer Hospital of Jiangsu Province, Nanjing 210009, China
关键词:
肺癌 表皮生长因子受体 突变 活检
分类号:
R656;R734.2
文献标志码:
摘要:
目的   评价应用CT导向肺癌穿刺活检标本检测表皮生长因子受体(EGFR)基因突变的价值。方法 21例穿刺前未接受肿瘤治疗,无其他肿瘤病史,临床诊断Ⅲ ~ Ⅳ期期肺癌病例。采用多排螺旋CT导向作病灶活检,所有标本均作病理学检查并采用PCR法检测EGFR突变。结果   ① 21例中9例使用18 G Chiba针,12例用20 G Chiba针。病理诊断为腺癌12例、鳞癌3例、小细胞癌1例、未分化癌5例。② 21例穿刺术后3例见针道少量渗血,无一例出现气胸。③ 21例标本中,共检测到EGFR突变10例(47.6%)。12例腺癌患者中8例检出EGFR突变,其他类型肿瘤2例突变;在12例女性患者中有8例发现EGFR体突变,9例男性患者有2例突变。结论   活检标本中EGFR基因突变可为临床药物分子靶向治疗提供依据。

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:20101021
更新日期/Last Update: 2011-04-30