[1]韩志刚,张国福,谢洁林,等.Ⅰｂ２ ～ Ⅱａ期宫颈癌根治性子宫切除术前子宫动脉栓塞化疗及髂内动脉前干支化疗的疗效比较[J].介入放射学杂志,2010,(12):955-957.
　HAN Zhi-gang,ZHANG Guo-fu,XIE Jie-lin,et al. Therapeutic comparison of uterine artery chemoembolization with internal iliac anterior trunk arterial chemotherapy performed before radical hysterectomy in patients with stages Ⅰb2-Ⅱa cervical cancer[J].journal interventional radiology,2010,(12):955-957.
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Ⅰｂ２ ～ Ⅱａ期宫颈癌根治性子宫切除术前子宫动脉栓塞化疗及髂内动脉前干支化疗的疗效比较()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2010年12期
页码:
955-957
栏目:
肿瘤介入
出版日期:
2010-12-25

文章信息/Info

Title:

Therapeutic comparison of uterine artery chemoembolization with internal iliac anterior trunk arterial chemotherapy performed before radical hysterectomy in patients with stages Ⅰb2-Ⅱa cervical cancer

作者:
韩志刚; 张国福; 谢洁林; 王士甲; 胡培安; 王冬燕; 张燕玉
200011  上海 复旦大学附属妇产科医院放射科
Author(s):

HAN Zhi-gang;  ZHANG Guo-fu;  XIE Jie-lin;  WANG Shi-jia;  HU Pei-an;  WANG Dong-yan;  ZHANG Yan-yu.
Department of Radiology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China
关键词:
宫颈癌; 　新辅助化疗; 　子宫动脉化疗栓塞
分类号:
Ｒ７３７.３３
文献标志码:
Ａ
摘要:
目的探讨Ⅰｂ２～Ⅱａ期宫颈癌根治性子宫切除术前不同动脉化疗方式的近期及远期疗效。方法将１５１例患者分为研究组和对照组，研究组１１３例采取子宫动脉栓塞化疗术，对照组３８例采取髂内动脉前干支化疗，术后２～４周内行根治性子宫切除术，观察化疗后２周内肿瘤变化及根治性子宫切除术后２、５年生存率。结果介入术前测量肿瘤最大径平均为（４．５８±０．３７）ｃｍ，介入术后最大径平均值（２．１１±０．２４）ｃｍ。在研究组和对照组完全有效率分别为３１．９％和２１．１％；总有效率为９４．７％（１０７／１１３）和７６．３％（２９／３８），２周内疗效研究组明显好于对照组（Ｐ值均＜０．０１）。两组手术切缘均未见癌浸润，研究组３例切缘见脉管转移，５例见宫旁浸润，盆腔淋巴结转移６例；对照组１例切缘脉管转移，２例宫旁浸润，１例盆腔淋巴结转移。研究组２年生存为６８／８４，５年生存为４７／６４；对照组２年生存２６／３２，５年生存１８／２４。两组２年及５年生存率比无明显差异（Ｐ值均＞０．０５）。结论子宫动脉化疗栓塞术短期内使宫颈癌肿瘤明显缩小，有利于外科手术剥离，近期疗效好于髂内动脉前干化疗，远期疗效无差异，是Ⅰｂ２～Ⅱａ期宫颈癌的首选新辅助动脉化疗方式。

参考文献/References:

[1] 丰有吉, 沈 铿. 妇产科学[M]. 北京: 人民卫生出版社, 2005: 316.
[2] Selvaggi L, Loizzi V, DI-Gilio AR, et al. Neoadjuvant chemotherapy in cervical cancer: a 67 patients experience[J]. Int J Gynecol Cancer, 2006, 16: 631 - 637.
[3] Kumar JV, Doval DC, Rao R, et al. A retrospective study of patients with locally advanced cancer of the cervix treated with neoadjuvant chemotherapy followed by radical surgery[J]. Int J Gynecol Cancer, 2009, 19: 417 - 422.
[4] 庞义存, 宋月卿. 巨块型宫颈癌介入化疗探讨[J]. 介入放射学杂志, 2004, 13: 530 - 531.
[5] Adachi S, Ogasawara T, Wakimoto E, et al.Cancer. Phase I/II study of intravenous nedaplatin and intraarterial cisplatin with transcatheter arterial embolization for patients with locally advanced uterine cervical carcinoma[J]. Cancer, 2001, 91: 74 - 79.
[6] 张 璇, 邓敏瑞, 舒慧芳, 等. 新辅助化疗的两种用药途径对局部晚期宫颈癌的疗效比较[J]. 广东医学, 2009, 30: 1120 - 1121.
[7] 孔秋英, 谢红宁. 妇产科影像与介入治疗学[M]. 北京: 人民卫生出版社, 2001.
[8] Park DC, Suh MJ, Yeo SG. Neoadjuvant paclitaxel and cisplatin in uterine cervical cancer: long-term results[J]. Int J Gynecol Cancer, 2009, 19: 943 - 947.
[9] Yamakawa Y, Fujimura M, Hidaka T, et al. Neoadjuvant intraarterial infusion chemotherapy in patients with stage IB2-IIIB cervical cancer[J]. Gynecol Oncol, 2000, 77: 264 - 270.
[10] 姚志敏, 佟小强, 宋 莉, 等. 宫颈癌术前动脉化疗栓塞疗效[J]. 介入放射学杂志, 2009, 18: 189 - 192.
[11] 张国福, 田晓梅, 韩志刚, 等. 介入化疗栓塞在宫颈癌术前的临床应用[J]. 介入放射学杂志, 2009, 18: 97 - 99.
[12] Nagata Y, Araki N, Kimura H, et al. Neoadjuvant chemotherapy by transcatheter arterial infusion method for uterine cervical cancer[J]. J Vasc Interv Radiol, 2000, 11: 313 - 319.
[13] 朱 军, 罗建钧, 张 雯, 等. 术前介入治疗对早期宫颈癌近?远期疗效的影响[J]. 介入放射学杂志, 2010, 19: 28 - 31.

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备注/Memo

备注/Memo:
收稿日期：２０１００８０６
更新日期/Last Update: 2010-12-25