[1]周慷,李晓光,金征宇,等.经双侧子宫动脉介入化疗对进展期宫颈癌的疗效观察[J].介入放射学杂志,2010,(06):482.
 ZHOU Kang,LI Xiaoguang,JIN Zhengyu,et al.Therapeutic effect of intra-arterial chemotherapy with DDP and5-FU via bilateral uterine arteries for advanced uterine cervical cancer[J].journal interventional radiology,2010,(06):482.
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经双侧子宫动脉介入化疗对进展期宫颈癌的疗效观察()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2010年06期
页码:
482
栏目:
临床研究
出版日期:
2010-06-15

文章信息/Info

Title:
Therapeutic effect of intra-arterial chemotherapy with DDP and5-FU via bilateral uterine arteries for advanced uterine cervical cancer
作者:
周慷李晓光金征宇
100730北京中国医学科学院北京协和医院放射科
Author(s):
ZHOU KangLI Xiao-guangJIN Zheng-yuYANG NingLIU WeiPAN JieZHANG Xiao-boSHI Hai-fengSUN HaoWANG Zhi-wei.
Peking Union Hospital,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing100730,China
关键词:
介入化疗进展期宫颈癌
分类号:
R737.33
文献标志码:
B
摘要:
目的评估经双侧子宫动脉灌注DDP+5-Fu对进展期宫颈癌的疗效和并发症。方法回顾我院妇产科2006年1月至2009年1月收治的72例初治原发性进展期宫颈癌患者(ⅠB2期28例,ⅡA期12例,ⅡB期32例;鳞癌56例,腺癌16例),均行经双侧子宫动脉DDP+5-Fu介入化疗,以化疗前后的B超检查及临床妇科检查对比判断疗效,观察化疗并发症,同时评估其手术切除率,分析术后病理结果。结果72例患者中54例完成1个疗程,18例完成2个疗程,共进行了90个疗程。介入治疗后肿瘤明显缩小,宫旁组织或阴道浸润消退,总有效率为77.8%,ⅠB2期有效率92.9%(26/28),ⅡA期有效率83.3%(10/12),ⅡB期有效率62.5%(20/32),三者比较差异有统计学意义(P<0.05)。鳞癌有效率85.7%(48/56),腺癌有效率50.0%(8/16);两者比较差异有统计学意义(P<0.05)。化疗不良反应主要表现为胃肠道反应和骨髓抑制。34例患者嗣后接受宫颈癌根治术,其中ⅠB2期22例(78.6%,22/28),ⅡA期8例(66.7%,8/12),ⅡB期4例(12.5%,4/32),三者比较差异有统计学意义(P<0.05)。术后病理:所有手术病例阴道切缘均无癌灶残存,无卵巢转移,6例患者盆腔淋巴结转移(17.6%),4例患者宫旁浸润(11.8%),均为ⅡA期和ⅡB期的患者。结论经双侧子宫动脉DDP+5-Fu术前介入化疗在近期内能安全有效的缩小宫颈癌病灶,抑制淋巴结转移及宫旁浸润,为手术创造条件并降低手术难度。对ⅠB2期患者疗效好于ⅡA和ⅡB期患者,对鳞癌有效率高于腺癌。

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2010-03-29
更新日期/Last Update: 2010-06-15