[1]贾中芝,黄渊全,冯耀良,等.原发性肝癌经导管动脉化疗栓塞术治疗前后血清血管内皮生长因子与CT灌注成像的相关性研究[J].介入放射学杂志,2010,(01):23.
　JIA Zhongzhi,HUANG Yuanquan,FENG Yaoliang,et al.Correlation between serum VEGF level and CT perfusion imaging in patients with primary liver cancer pre－and post TACE[J].journal interventional radiology,2010,(01):23.
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原发性肝癌经导管动脉化疗栓塞术治疗前后血清血管内皮生长因子与CT灌注成像的相关性研究()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2010年01期
页码:
23
栏目:
肿瘤介入
出版日期:
2010-01-15

文章信息/Info

Title:
Correlation between serum VEGF level and CT perfusion imaging in patients with primary liver cancer pre－and post TACE
作者:
贾中芝; 黄渊全; 冯耀良; 施海彬
２１００２９江苏南京医科大学第一附属医院介入放射科
Author(s):
JIA Zhong－zhi ; HUANG Yuan－quan; FENG Yao－liang; SHI Hai－bin
the First Hospital Affiliated to Nanjing Medical University，Nanjing２１００２９，China
关键词:
原发性肝癌; 血管内皮生长因子; CT灌注成像; 经导管动脉栓塞
分类号:
R７３５.７
文献标志码:
A
摘要:
目的探讨原发性肝癌（PLC）患者行经导管动脉栓塞（TACE）术前、术后血清血管内皮生长因子（VEGF）与肿瘤组织CT灌注参数的相关性。方法对１８例PLC患者TACE术前１d，术后６～８d、３２～４０d行血清VEGF检测及CT灌注扫描成像（CTPI ），得到血清VEGF、肿瘤组织肝动脉灌注量（ALP）、门静脉灌注量（PVP）、肝动脉灌注指数（HPI ）等参数值，并进行统计学分析。结果根据TACE治疗效果分为完全缓解（CR）组和部分缓解及无变化（PR＋SD）组。术前两组血清VEGF及ALP、PVP、HPI 差异无统计学意义（P＞０．０５）；术后６～８d两组血清VEGF及PVP较术前变化差异无统计学意义（P＞０．０５），而ALP、HPI 较术前明显降低（P＜０．０５）。术后３２～４０d，CR组血清VEGF较术前明显降低（P＜０．０５），PR＋SD组则较术前增高，但差异无统计学意义（P＝０．２２１）。血清VEGF与肿瘤组织ALP、HPI 呈正相关。结论血清VEGF能间接反映TACE术后肿瘤组织微血管及侧支循环生成情况；CTPI 能直观和定量反映肿瘤组织TACE术前后的血流动力学变化；血清VEGF与肿瘤组织ALP、HPI 呈正相关。故联合应用血清VEGF及CTPI 有助于TACE疗效的评价，对进一步治疗时间、方案的确定提供重要参考依据。

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备注/Memo

备注/Memo:
收稿日期：２００９－０６－２９
更新日期/Last Update: 2010-01-15