[1]马永强,杨宁,张晓峰,等.急性肠系膜上动脉栓塞动物模型的建立[J].介入放射学杂志,2009,(06):466.
　MA Yong-qiang,YANG Ning,ZHANG Xiao-feng,et al.The establishment of the animal model of acute superior mesenteric artery embolization[J].journal interventional radiology,2009,(06):466.
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急性肠系膜上动脉栓塞动物模型的建立()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2009年06期
页码:
466
栏目:
实验研究
出版日期:
2009-06-15

文章信息/Info

Title:
The establishment of the animal model of acute superior mesenteric artery embolization
作者:
马永强; 杨宁; 张晓峰; 等
１０００８３北京大学第三医院放射科（马永强）；北京协和医院放射科（杨宁）；北京妇产医院放射科（张晓峰）；北京军区总医院放射科（路军良）
Author(s):
MA Yong-qiang; YANG Ning; ZHANG Xiao-feng; LU Jun-liang．
Department of Radiology，the Third Hospital of Peking University，Beijing１０００８３，China
关键词:
肠系膜上动脉; 栓塞; 动物模型
分类号:
R５４３.５
文献标志码:
A
摘要:
目的制作一种适合后续去栓治疗的急性肠系膜上动脉栓塞动物模型。方法８只杂种犬，体外制作动物自体血栓，采用经皮股动脉穿刺入路，选择性插入８F动脉长鞘至犬肠系膜上动脉主干后注入自体血凝块，造影复查直至肠系膜上动脉主干完全闭塞。分别在栓塞后２、４、６和８h于肠系膜上动脉开口部造影复查，观察自体血栓是否稳定，肠系膜上动脉有无自行再通，并经腹部切口探察，取病理活检。结果８只实验犬均成功建立急性肠系膜上动脉栓塞致肠缺血模型。大体观察及镜下可见随栓塞时间的延长，肠管损伤逐渐加重，组内一致性良好。结论采用本实验方法可成功建立适合后续去栓治疗研究的急性肠系膜上动脉栓塞动物模型。

参考文献/References:

［１］黄品婕，蔡珺，甘小亮，等．SD大鼠不同肠缺血时间观察长期存活率模型的筛选［J］．实用医学杂志，２００７，２３：２９８３-２９８４．
［２］Han YM，Lee JM，Jin KY，et al．Embolization of superior mesenteric artery branches in dogs．ischemic bowel changes depend on location of vessel occlusion and embolic materials［J］．Inves

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备注/Memo

备注/Memo:
收稿日期：２００９-０２-１６
更新日期/Last Update: 2009-06-15