[1]朱虹颖,嵇再雄,王建波.血管外膜在血管成形术后再狭窄中的作用[J].介入放射学杂志,2023,32(03):293-297.
 ZHU Hongying,JI Zaixiong,WANG Jianbo..The role of adventitia in the formation of restenosis after angioplasty[J].journal interventional radiology,2023,32(03):293-297.
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血管外膜在血管成形术后再狭窄中的作用()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
32
期数:
2023年03
页码:
293-297
栏目:
综述
出版日期:
2023-03-31

文章信息/Info

Title:
The role of adventitia in the formation of restenosis after angioplasty
作者:
朱虹颖 嵇再雄 王建波
Author(s):
ZHU Hongying JI Zaixiong WANG Jianbo.
Department of Biology, College of Fisheries and Life, Shanghai Ocean University, Shanghai 201306, China
关键词:
【关键词】 血管再狭窄 血管重塑 外膜成纤维细胞 炎性微环境
文献标志码:
A
摘要:
【摘要】 血管成形术是治疗血管狭窄、改善患者生活质量的重要手段。然而血管成形术可能会导致内膜过度增生,血管成形术再狭窄已成为临床严重问题。血管外膜由多种类型细胞组成,与血管成形术后再狭窄密切相关。血管损伤后激活的外膜成纤维细胞(AF)可转化为肌成纤维细胞(MF)并向内膜迁移,同时促进产生各种细胞因子和炎性分子,而AF衍生的活性氧(ROS)引起的氧化应激也会参与血管炎症,这一炎性反应加剧了血管再狭窄。炎性微环境下,祖细胞分化加剧,脂肪细胞功能失调,引起细胞增殖。本文首次综述了几种外膜细胞如AF、炎性细胞、祖细胞和脂肪细胞在血管成形术后血管重构和内膜增殖中的关键作用。

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备注/Memo

备注/Memo:
(收稿日期:2022- 01- 05)
(本文编辑:边 佶)
更新日期/Last Update: 2023-03-28