[1]徐 克,宋梦宇,赵金鑫,等.TPS模拟不同活度125I胆道粒子链剂量学研究[J].介入放射学杂志,2026,(09):1015-1020.[doi:10.3969/j.issn.1008-794X.2026.09.008]
　XU Ke,SONG Mengyu,ZHAO Jinxin,et al.Dosimetric study of intrabiliary 125I seed strands with different activities simulated by treatment planning system[J].J Intervent Med,2026,(09):1015-1020.[doi:10.3969/j.issn.1008-794X.2026.09.008]
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TPS模拟不同活度125I胆道粒子链剂量学研究()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2026年09
页码:
1015-1020
栏目:
实验研究
出版日期:
2026-09-10

文章信息/Info

Title:
Dosimetric study of intrabiliary 125I seed strands with different activities simulated by treatment planning system
文章编号:
1008-794X(2026)-009-1015-06
作者:
徐 克;  宋梦宇;  赵金鑫;  刘泽洲;  曹国辉;  王泽阳;  王 娟;  张宏涛
050051 河北石家庄 河北省肿瘤放射性粒子植入诊疗中心、河北省放射性粒子近距离治疗研究所、河北省人民医院肿瘤一科(徐 克,赵金鑫,刘泽洲,曹国辉,王泽阳,王 娟,张宏涛); 050011 河北石家庄 河北医科大学第四医院影像科(宋梦宇)
Author(s):
XU Ke1; SONG Mengyu2; ZHAO Jinxin1; LIU Zezhou1; CAO Guohui1; WANG Zeyang1; WANG Juan1; ZHANG Hongtao1.
1Section I,Department of Oncology,Hebei Provincial People's Hospital(Hebei Provincial Cancer Radioactive Particle Implantation Diagnosis and Treatment Center/Hebei Provincial Radioactive Seeds Brachytherapy Institute),Shijiazhuang,Hebei Province 050051,China; 2Department of Radiology,Fourth Hospital of Hebei Medical University,Shijiazhuang,Hebei Province 050011,China
关键词:
粒子链;  三维治疗计划系统;  活度;  剂量优化;  模拟
分类号:
R735.8
DOI:
10.3969/j.issn.1008-794X.2026.09.008
文献标志码:
A
摘要:
目的 通过三维治疗计划系统(3D treatment planning system,3D-TPS)模拟不同活度125I粒子链的剂量分布特征,探讨最适合胆道肿瘤治疗的放射性活度范围。方法 通过扫描河北省肿瘤放射性粒子植入诊疗中心粒子剂量测量模体,采用3D-TPS计划系统,勾画直径8 mm(胆道),管壁厚度1.5 mm,长度7 cm的腔道肿瘤模型,在肿瘤中心位置分别模拟0.3～1.0 mCi长度为11 cm粒子链,将粒子链中心点上下两侧5 mm点分别定义为A点与A'点,中心点10 mm上下两侧分别定义为B点与B'点,左侧粒子链边缘上下5 mm为AL点与AL'点,右侧粒子链边缘上下5 mm为AR点与AR'点,同理在以上位置点10 mm处点命名为BL点、BL'点、BR点、BR'点,并分别计算A点及B点1～3月实际吸收剂量,按照活度大小将0.3～0.4 mCi定义为低活度组,0.5～0.6 mCi为中活度组,0.7～1.0 mCi为高活度组,将3组数据进行对比,中心处剂量与端点位置剂量点进行对比,并将A、B两点术后1至3月实际吸收剂量与粒子活度进行曲线拟合,寻找其与粒子活度的关联性。结果 各点剂量与活度差异存在统计学意义(P<0.05),中心处各点与端点比较差异存在统计学意义(P<0.05),高活度组与中、低活度组对比差异存在统计学意义(P<0.05),A、B两点及术后1至3月吸收剂量呈线性相关,其中A、B点点剂量与活度分别得出拟合曲线:y=212.42x+0.252(R2=1.000)、y=130.83x+0.136(R2=1.000)。结论 高活度粒子保证粒子链植入剂量,可作为粒子链治疗胆道肿瘤首选活度范围。

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(收稿日期:2026-01-12)
(本文编辑:元 禾)

相似文献/References:

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　ZHAO Shaojun,GAO Zhen,YU Huimin,et al.Advances in 125I radioactive particle chains for cancer treatment[J].J Intervent Med,2026,(09):944.[doi:10.3969/j.issn.1008-794X.2026.08.020]

备注/Memo

备注/Memo:
基金项目: 河北省卫计委科研基金项目(20242265)
通信作者: 张宏涛 Email:hongtaozhangmd@163.com
更新日期/Last Update: 2026-09-25