[1]田志刚,杨 茂,国永飞,等.术前超选择性直肠上动脉灌注化疗在局部进展期直肠癌转化治疗中的临床应用[J].介入放射学杂志,2026,(05):556-560.[doi:10.3969/j.issn.1008-794X.2026.05.016 ]
　TIAN Zhigang,YANG Mao,GUO Yongfei,et al.Clinical application of preoperative superselective superior rectal artery infusion chemotherapy in conversion therapy for locally advanced rectal cancer[J].J Intervent Med,2026,(05):556-560.[doi:10.3969/j.issn.1008-794X.2026.05.016 ]
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术前超选择性直肠上动脉灌注化疗在局部进展期直肠癌转化治疗中的临床应用()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2026年05
页码:
556-560
栏目:
临床研究
出版日期:
2026-05-25

文章信息/Info

Title:
Clinical application of preoperative superselective superior rectal artery infusion chemotherapy in conversion therapy for locally advanced rectal cancer
文章编号:
1008-794X(2026)-005-0556-05
作者:
田志刚;  杨 茂;  国永飞;  王 艳;  张炜浩;  司同国
300308 天津 天津市肿瘤医院空港医院微创介入科(田志刚、杨 茂、国永飞、王 艳、司同国); 天津医科大学肿瘤医院介入治疗科(张炜浩)
Author(s):
TIAN Zhigang; YANG Mao; GUO Yongfei; WANG Yan; ZHANG Weihao; SI Tongguo.
Department of Minimally Invasive Intervention,Tianjin Municipal Cancer Hospital Airport Hospital,Tianjin 300308,China
关键词:
局部进展期直肠癌;  动脉灌注化疗;  转化治疗
分类号:
R735.35
DOI:
10.3969/j.issn.1008-794X.2026.05.016
文献标志码:
B
摘要:
目的 评估术前超选择性直肠上动脉灌注化疗术新辅助治疗局部进展期直肠癌(locally advanced rectal cancer,LACR)的临床疗效及不良反应。方法 回顾性分析天津市肿瘤医院空港医院33例接受选择性直肠上动脉灌注化疗术 LACR患者的临床资料,评估超选择性直肠上动脉灌注化疗术后患者的手术率、R0切除率、保肛率、不良反应、TN分期、肿瘤标志物变化、TRG分级、肿瘤最大径、肿瘤与肛缘距离等相关指标,总结该治疗方法的疗效及不良反应发生率。结果 直肠上动脉灌注化疗术患者共33例,在治疗结束后疗效评价,①影像学评估:部分缓解(partial response,PR)24例,均行手术治疗; 疾病稳定(stable disease,SD)8例,其中6例行手术治疗,2例改为静脉化疗; 疾病进展(progressive disease,PD)1例,改为静脉化疗; 30例手术患者中:24例肿瘤最大径缩小、5例T分期降低、15例N分期降低; ②肿瘤标志物:癌胚抗原(carcinoembryonicantigen,CEA)、糖抗原724(carbohydrate antigen 724,CA724)、糖抗原242(carbohydrate antigen 242,CA242)阳性患者18例,其中16例在直肠上动脉灌注术后下降; ③30例行直肠癌根治术,均实现R0切除,28例实现保肛; ④术后病理评估:TRG分级0级1例、1级5例、2级21例、3级3例; ⑤不良反应:8例出现骨髓抑制,其中Ⅲ度以上1例; 轻度肝功能异常1例; 轻度腹泻2例; 轻度脱发3例; 轻度恶心、呕吐3例; 无肠系膜动脉缺血并发症。结论 选择性直肠上动脉灌注化疗可以提高局部进展期直肠癌的手术切除率与保肛率,不良反应较小,是局部进展期直肠癌转化治疗的方法之一。

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(收稿日期:2025-04-04)
(本文编辑:元 禾)

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备注/Memo

备注/Memo:
通信作者: 司同国 E-mail:sitongguo@tjmuch.com
更新日期/Last Update: 2026-05-25