[1]华 秋,黄 静.射频消融联合腹腔神经丛射频热凝治疗中晚期肝癌患者的临床疗效[J].介入放射学杂志,2026,(03):307-312.[doi:10.3969/j.issn.1008-794X.2026.03.013]
　HUA Qiu,HUANG Jing..Radiofrequency ablation combined with radiofrequency thermocoagulation of celiac plexus in the treatment of patients with advanced liver cancer:analysis of its clinical efficacy[J].J Intervent Med,2026,(03):307-312.[doi:10.3969/j.issn.1008-794X.2026.03.013]
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射频消融联合腹腔神经丛射频热凝治疗中晚期肝癌患者的临床疗效()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2026年03
页码:
307-312
栏目:
临床研究
出版日期:
2026-03-25

文章信息/Info

Title:
Radiofrequency ablation combined with radiofrequency thermocoagulation of celiac plexus in the treatment of patients with advanced liver cancer:analysis of its clinical efficacy
文章编号:
1008-794X(2026)-003-0307-06
作者:
华 秋;  黄 静
211112 江苏常州 南京医科大学第三附属医院放疗科(华 秋),疼痛科(黄 静)
Author(s):
HUA Qiu; HUANG Jing.
Department of Radiotherapy,Third Affiliated Hospital of Nanjing Medical University,Changzhou,Jiangsu Province 211112,China
关键词:
射频消融;  腹腔神经丛射频热凝;  原发性肝癌;  疼痛
分类号:
R735.7
DOI:
10.3969/j.issn.1008-794X.2026.03.013
文献标志码:
B
摘要:
目的 探讨CT引导下射频消融(radiofrequency ablation,RFA)联合腹腔神经丛射频热凝(celiac plexus radiofrequency thermocoagulation,CPRF)在伴有中重度顽固性疼痛中晚期原发性肝癌疼痛患者中的疗效。方法 回顾性分析2019年4月至2021年5月在南京医科大学第三附属医院接受治疗的原发性肝癌患者102例,根据治疗方案分为观察组54例和对照组48例。对照组实施RFA治疗,观察组实施RFA联合CPRF治疗。比较两组穿刺引导时间、操作时间、术后并发症、肿瘤标志物[癌胚抗原(carcinoembryonic antigen,CEA)、甲胎蛋白(alpha-fetoprotein,AFP)、糖类抗原125(carbohydrate antigen 125,CA125)]、肝功能指标[谷草转氨酶(aspartate aminotransferase,AST)、谷丙转氨酶(alanine aminotransferase,ALT)]、疼痛反应、局部复发率、总生存期(OS)和无进展生存期(PFS)。结果 两组患者的手术成功率均为100.00%,术中、术后未见严重并发症。术中,观察组和对照组的穿刺引导时间分别为31.61(26.95～38.45)min、23.07(20.24～29.17)min(P<0.05); 操作时间分别为54.59(49.47～65.26)min、41.16(31.89～50.71)min(P<0.05)。观察组术后恶心/呕吐、腹泻及腰部区域麻木的占比高于对照组(P<0.05)。治疗后,两组血清CEA、AFP、CA125、AST、ALT水平均降低(P<0.05),组间比较差异无统计学意义(P>0.05)。术后24、48 h,两组患者的疼痛评分较术前降低,观察组低于对照组(P<0.05)。术后1、3年,观察组的局部复发率分别为31.48%、53.70%,对照组的局部复发率分别为35.42%、60.42%; 两组患者均未达到中位OS,中位PFS分别为35、28个月,两组局部复发率及PFS比较差异均无统计学意义(P>0.05)。结论 RFA联合CPRF治疗能够有效减轻原发性肝癌患者术后的疼痛程度。

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(收稿日期:2025-05-19)
(本文编辑:元 禾)

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备注/Memo

备注/Memo:
通信作者: 黄 静 E-mail:h19840700312@163.com
更新日期/Last Update: 2026-03-25