[1]钱 玲,孟志强.冷冻消融治疗肿瘤现状和展望[J].介入放射学杂志,2026,(03):243-248.[doi:10.3969/j.issn.1008-794X.2026.03.002 ]
　QIAN Ling,MENG Zhiqiang..The current status and future prospects of cryoablation therapy for tumors[J].J Intervent Med,2026,(03):243-248.[doi:10.3969/j.issn.1008-794X.2026.03.002 ]
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冷冻消融治疗肿瘤现状和展望()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2026年03
页码:
243-248
栏目:
专论
出版日期:
2026-03-25

文章信息/Info

Title:
The current status and future prospects of cryoablation therapy for tumors
文章编号:
1008-794X(2026)-003-0243-06
作者:
钱 玲;  孟志强
200031 上海 复旦大学附属肿瘤医院肿瘤微创治疗中心、癌症研究中心
Author(s):
QIAN Ling; MENG Zhiqiang.
Cancer Minimally Invasive Treatment Center,Affiliated Cancer Hospital of Fudan University and Cancer Research Center,Shanghai 200031,China
关键词:
冷冻消融;  局部微创治疗;  肿瘤;  肝肿瘤;  联合治疗
分类号:
R730.5
DOI:
10.3969/j.issn.1008-794X.2026.03.002
文献标志码:
A
摘要:
局部微创消融日益广泛地应用于实体肿瘤治疗,尤其是为无法外科手术或手术耐受性差患者提供了重要的替代方案。冷冻消融(cryoablation,CRA)作为一种基于超低温微创治疗方式,通过冷冻探针在靶区诱导肿瘤细胞坏死并释放肿瘤相关抗原,理论上能激活后续的抗肿瘤免疫反应。CRA技术潜在优势在于影像下消融边界清晰、创伤较小、痛感较低以及免疫激活较强等,已逐渐成为前列腺癌、肾癌、肺癌、肝肿瘤等多种肿瘤的重要治疗手段。该文综合介绍CRA技术作用机制、优势及其在多种肿瘤治疗中应用,重点探讨其在肝肿瘤治疗中的安全性和有效性,并总结CRA联合化疗、靶向治疗、免疫治疗等应用策略。尽管CRA展现出良好的临床应用潜能,但仍存在穿刺道出血、治疗时间较长及冷冻休克风险等局限性。未来通过设备创新、手术流程优化和大规模临床研究,CRA有望在实体肿瘤治疗中发挥更大作用,为患者提供更精准、安全的治疗选择。

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(收稿日期:2025-05-15)
(本文编辑:谷 珂)

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备注/Memo

备注/Memo:
通信作者: 孟志强 E-mail:mengshca@fudan.edu.cn
更新日期/Last Update: 2026-03-25