[1]叶 娟,尚海龙,沈海林,等.DSA引导下食蟹猴大脑中动脉栓塞模型的建立与评价[J].介入放射学杂志,2022,31(04):369-373.
 YE Juan,SHANG Hailong,SHEN Hailin,et al.Establishment of DSA-guided middle cerebral artery embolization mode in cynomolgus monkeys and its technical evaluation[J].journal interventional radiology,2022,31(04):369-373.
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DSA引导下食蟹猴大脑中动脉栓塞模型的建立与评价()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
31
期数:
2022年04
页码:
369-373
栏目:
实验研究
出版日期:
2022-06-15

文章信息/Info

Title:
Establishment of DSA-guided middle cerebral artery embolization mode in cynomolgus monkeys and its technical evaluation
作者:
叶 娟 尚海龙 沈海林 杜红娣 沈 萍 朱 枫 邱志富 曹 莹 赵芳红 王 莺
Author(s):
YE Juan SHANG Hailong SHEN Hailin DU Hongdi SHEN Ping ZHU Feng QIU Zhifu CAO Ying ZHAO Fanghong WANG Ying.
Department of Medical Imaging, Suzhou Kowloon Hospital, School of Medicine, Shanghai Jiao Tong University, Suzhou, Jiangsu Province 215028, China
关键词:
【关键词】 食蟹猴 DSA导引 大脑中动脉闭塞 动物模型 影像评价
文献标志码:
A
摘要:
【摘要】 目的 建立并评价DSA导引下食蟹猴大脑中动脉闭塞(MCAO)模型。方法 纳入15只成年雄性食蟹猴。DSA导引下经股动脉切开通过导管向大脑中动脉(MCA)注入猴自体静脉血栓凝块构建MCAO模型。术后分别行颅脑MRI和头颈部CTA+CT灌注(CTP)检查,以明确MCA梗塞后影像学变化。术后7 d连续观察实验猴行为表现,于术后第8天处死,取脑组织行三苯基四唑氯染色。 结果 15只实验猴中1只术前头颈部CTA提示颅内血管畸形,未行手术。14只接受手术的猴中12只经DSA、头颈部CTA+CTP及颅脑MRA扫描证实MCA闭塞成功;1只术中死亡;另1只栓塞后DSA及CT、MRI扫描均显示无明显缺血,麻醉复苏后无脑缺血行为表现。12只实验猴术后均存活,神经功能评分提示有神经功能缺损,其缺损变化与影像学改变相符。结论 DSA导引下将自体静脉血栓引入MCA建立的食蟹猴MCAO模型具有手术创伤小、可重复性高、稳定性强的特点。

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备注/Memo

备注/Memo:
(收稿日期:2021- 09- 12)
(本文编辑:边 佶)
更新日期/Last Update: 2022-05-11