[1]李虎子,段振东,赵 成,等.TACE联合冷冻消融治疗不可切除肝癌临床疗效的meta分析[J].介入放射学杂志,2021,30(08):804-813.
 LI Huzi,DUAN Zhendong,ZHAO Cheng,et al.TACE combined with cryoablation for inoperable liver cancers: a meta analysis of clinical efficacy[J].journal interventional radiology,2021,30(08):804-813.
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TACE联合冷冻消融治疗不可切除肝癌临床疗效的meta分析()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
30
期数:
2021年08
页码:
804-813
栏目:
临床研究
出版日期:
2021-08-25

文章信息/Info

Title:
TACE combined with cryoablation for inoperable liver cancers: a meta analysis of clinical efficacy
作者:
李虎子 段振东 赵 成 方文岩 张 洪 贺 斌 李 悦
Author(s):
LI Huzi DUAN Zhendong ZHAO Cheng FANG Wenyan ZHANG Hong HE Bin LI Yue.
Department of Oncology, First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300182, China
关键词:
【关键词】 肝癌 肝动脉化疗栓塞术 冷冻消融 meta分析
文献标志码:
A
摘要:
【摘要】 目的 对比分析肝动脉化疗栓塞(TACE)联合冷冻消融治疗与单独TACE治疗不可切除肝癌的临床疗效。方法 计算机检索关于TACE联合冷冻消融(实验组)与单独TACE治疗(对照组)肝癌的随机对照试验(RCT),制定纳入和排除标准进行筛选,对比分析短期疗效和远期生存率。结果 经过纳入标准和排除标准筛选,纳入5篇RCT文献,共418例患者进行meta分析,结果显示:实验组的完全缓解(CR)(RR=2.20,95%CI:1.51~3.22,P<0.000 1)、客观缓解率(ORR)(RR=1.49,95%CI:1.26~1.77,P<0.000 1)、疾病控制率(DCR)(RR=1.23,95%CI:1.12~1.35,P<0.000 1),1年(RR=1.38,95%CI:1.20~1.60,P<0.000 1)和2年(RR=1.68,95%CI:1.23~2.29,P=0.001)生存率明显高于对照组,而疾病进展(PD)(RR=0.38,95%CI:0.24~0.59,P<0.000 1)明显低于对照组。进一步对采用mRECIST短期疗效评价的2篇RCT研究meta分析显示:实验组ORR(RR=1.35,95%CI:1.02~1.78,P=0.03)、DCR(RR=1.27,95%CI:1.07~1.50,P=0.005)明显高于对照组,而PD明显低于对照组(RR=0.36,95%CI:0.17~0.76,P=0.007)。结论 TACE联合冷冻消融治疗不可切除肝癌的临床疗效优于单独TACE治疗。

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备注/Memo

备注/Memo:
(收稿日期:2020- 06- 25)
(本文编辑:俞瑞纲)
更新日期/Last Update: 2021-08-18