[1]杜自忠,王 晨,张明星,等.下肢动脉硬化闭塞症患者介入治疗后血清miR-342-5p水平及其意义[J].介入放射学杂志,2020,29(09):894-898.
 DU Zizhong,WANG Chen,ZHANG Mingxin,et al.Serum level of miR-342-5p and its clinical significance in patients with arteriosclerosis obliterans of lower extremity after interventional therapy[J].journal interventional radiology,2020,29(09):894-898.
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下肢动脉硬化闭塞症患者介入治疗后血清miR-342-5p水平及其意义()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
29
期数:
2020年09
页码:
894-898
栏目:
血管介入
出版日期:
2020-09-25

文章信息/Info

Title:
Serum level of miR-342-5p and its clinical significance in patients with arteriosclerosis obliterans of lower extremity after interventional therapy
作者:
杜自忠 王 晨 张明星 靳金龙 赵 丹 马书平 白会玲 章 立
Author(s):
DU Zizhong WANG Chen ZHANG Mingxin JIN Jinlong ZHAO Dan MA Shuping BAI Huiling ZHANG Li.
Department of Peripheral Vascular Intervention, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, Gansu Province 730050, China
关键词:
【关键词】 下肢动脉硬化闭塞症 miR-342-5p 预后
文献标志码:
A
摘要:
【摘要】 目的 探讨下肢动脉硬化闭塞症患者介入治疗后血清miR-342-5p水平及其意义。方法 选取2015年3月至2018年3月甘肃省中医院诊治的195例下肢动脉硬化闭塞症患者作为研究对象。根据患者预后情况,分为预后良好组(n=160)和预后不良组(n=35)。检测介入治疗前后患者血清miR-342-5p相对表达,分析其与预后的关系。结果 介入治疗后两组患者血清miR-342-5p相对表达均降低,预后良好组降低幅度高于预后不良组(P<0.05)。Logistic多因素回归分析结果显示,伴糖尿病、伴高脂血症、吸烟史、泛大西洋学会联盟(TASC)分型、C反应蛋白(CRP)、miR-342-5p与下肢动脉硬化闭塞症患者介入治疗预后密切相关。二元回归分析显示,模型B评估介入治疗预后曲线下面积(AUC)高于miR-342-5p和模型A,差异均有显著统计学意义(Z=2.683,P=0.007;Z=4.624,P<0.001)。结论 miR-342-5p与介入治疗后下肢动脉硬化闭塞症患者预后密切相关,检测血清miR-342-5p相对表达有助于评估患者介预后。

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备注/Memo

备注/Memo:
(收稿日期:2019- 10- 10)
(本文编辑:边 佶)
更新日期/Last Update: 2020-09-15