[1]刘 强,王永利,王征宇,等.导管接触溶栓治疗急性下肢深静脉血栓形成时D-二聚体和纤维蛋白原变化规律 [J].介入放射学杂志,2019,28(05):421-425.
 LIU Qiang,WANG Yongli,WANG Zhengyu,et al.Study on the changes of plasma D- dimmer and fibrinogen concentrations in catheter- directed thrombolysis for acute lower extremity deep venous thrombosis[J].journal interventional radiology,2019,28(05):421-425.
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导管接触溶栓治疗急性下肢深静脉血栓形成时D-二聚体和纤维蛋白原变化规律
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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
28
期数:
2019年05期
页码:
421-425
栏目:
血管介入
出版日期:
2019-05-25

文章信息/Info

Title:
Study on the changes of plasma D- dimmer and fibrinogen concentrations in catheter- directed thrombolysis for acute lower extremity deep venous thrombosis
作者:
刘 强 王永利 王征宇 彭志清 相建峰 陈 亮
Author(s):
LIU Qiang WANG Yongli WANG Zhengyu PENG Zhiqing XIANG Jianfeng CHEN Liang.
Department of Interventional Radiology, South Branch of Affiliated Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai 201499, China
关键词:
【关键词】 下肢深静脉血栓形成 导管接触溶栓 D-二聚体 纤维蛋白原
文献标志码:
A
摘要:
【摘要】 目的 研究导管接触溶栓(CDT)治疗急性下肢深静脉血栓形成(LEDVT)过程中血浆D-二聚体(D- D)和纤维蛋白原(FIB)变化,分析其意义。方法 选取2016年12月至 2017年12月采用CDT术治疗的18例急性LEDVT患者,治疗中每隔8 h检测患者血浆D- D、FIB浓度。计算每例患者D- D峰值、D- D上升速度、FIB下降速度及D- D增高时间,统计学分析D- D、FIB变化规律,以及D- D峰值、D- D上升速度、FIB下降速度及D- D增高时间之间相关性和线性关系。结果 CDT术后18例患者中13例(72%)疗效评价为优或良,无严重出血并发症发生。CDT治疗中尿激酶微泵速度不变情况下,D- D先上升后下降,FIB持续下降;尿激酶微泵速度减半后,D- D下降速度变缓,FIB逐渐上升。统计学分析显示,D- D峰值与D- D上升速度呈正相关(Pearson比0.88,P<0.01),D- D峰值与D- D增高时间呈正相关(Pearson比0.80,P<0.01),D- D上升速度与D- D增高时间呈正相关(Pearson比0.62,P=0.01),D- D上升速度与FIB下降速度呈正相关(Pearson比0.49,P=0.04),D- D峰值与FIB下降速度呈正相关(Pearson比0.76,P<0.01),D- D增高时间与FIB下降速度间无相关性。结论 急性LEDVT患者CDT治疗过程中血浆D- D、FIB会产生规律性变化,监测和分析D- D、FIB变化规律,有助于提高CDT疗效,减少并发症。

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备注/Memo

备注/Memo:
(收稿日期:2018-07-17)
(本文编辑:边 佶)
更新日期/Last Update: 2019-05-11