[1]周 炜,庄治国,池嘉昌,等.导管室内平板探测器CT定量评估兔肝肿瘤血管生成研究[J].介入放射学杂志,2017,(10):907-911.
 ZHOU Wei,ZHUANG Zhiguo,CHI Jiachang,et al.Quantitative assessment of angiogenesis of rabbit liver tumors by using flat detector CT in the angiography suite[J].journal interventional radiology,2017,(10):907-911.
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导管室内平板探测器CT定量评估兔肝肿瘤血管生成研究()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2017年10期
页码:
907-911
栏目:
实验研究
出版日期:
2017-10-25

文章信息/Info

Title:
Quantitative assessment of angiogenesis of rabbit liver tumors by using flat detector CT in the angiography suite
作者:
周 炜 庄治国 池嘉昌 所世腾 管 逊 许建荣
Author(s):
ZHOU Wei ZHUANG Zhiguo CHI Jiachang SUO Shiteng GUAN Xun XU Jianrong
Department of Radiology, Affiliated Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
关键词:
【关键词】 平板探测器 计算机断层摄影 肝肿瘤 血容量 微血管密度 血管内皮细胞生长因子
文献标志码:
A
摘要:
【摘要】 目的 探讨导管室内平板探测器CT(FDCT)技术定量评估肝肿瘤血管生成的可行性。方法25只新西兰大白兔VX2肝肿瘤模型构建后行FDCT检查,重建肿瘤血容量(BV)灌注图,分别检测肝肿瘤和肝实质BV值。FDCT检查后处死所有实验兔,取相应部位肝肿瘤标本检测微血管密度(MVD)和血管内皮细胞生长因子(VEGF)表达,分析肝肿瘤BV值与MVD和VEGF表达的关系。结果 25只实验兔中22只兔(88%)成功完成FDCT检查,BV灌注图均清晰显示肝组织和肿瘤,肝肿瘤表现为高灌注环伴低灌注中心的环状强化模式。肿瘤BV值与MVD和VEGF分级均存在良好相关性(P值均<0.05),MVD与VEGF分级呈正相关(r=0.504,P<0.001)。结论 导管室内FDCT检查可定量评估肝肿瘤血管生成情况,可能有助于肝肿瘤介入诊疗。

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备注/Memo

备注/Memo:
(收稿日期:2017-01-18)
(本文编辑:边 佶)
更新日期/Last Update: 2017-10-15