[1]章美武,张 燕,范晓翔,等.甲状腺细针穿刺细胞学联合BRAF基因检测的诊断价值 [J].介入放射学杂志,2017,(07):622-626.
 ZHANG Meiwu,ZHANG Yan,FAN Xiaoxiang,et al.Thyroid cytological examination by using fine needle aspiration biopsy combined with BRAF gene testing: its diagnostic value in differentiating benign from malignant thyroid nodules[J].journal interventional radiology,2017,(07):622-626.
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甲状腺细针穿刺细胞学联合BRAF基因检测的诊断价值



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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2017年07期
页码:
622-626
栏目:
非血管介入
出版日期:
2017-07-25

文章信息/Info

Title:
Thyroid cytological examination by using fine needle aspiration biopsy combined with BRAF gene testing: its diagnostic value in differentiating benign from malignant thyroid nodules
作者:
章美武 张 燕 范晓翔 毛达峰 吕淑懿
Author(s):
ZHANG Meiwu ZHANG Yan FAN Xiaoxiang MAO Dafeng Lv Shuyi.
Department of Intervention, Ningbo Municipal No.2 Hospital, Ningbo, Zhejiang Province 315010, China
关键词:
【关键词】 甲状腺结节 细针穿刺细胞学 鼠类肉瘤滤过性毒菌致癌基因同源体B1 突变
文献标志码:
A
摘要:
【摘要】 目的 评价甲状腺细针穿刺细胞学(FNAB)联合BRAF V600E基因检测对甲状腺结节良恶性鉴别的诊断价值。方法 总结经手术病理证实的64个甲状腺结节术前超声引导下细针穿刺细胞学检查和BRAF V600E基因检测的资料,以手术后组织病理学结果作为甲状腺结节性质的诊断金标准,分析FNAB、BRAF V600E基因检测以及两者联合诊断的价值。结果 62例患者64个结节(2例双侧)接受手术处理,其中共有44个结节检测到BRAF V600E突变,43个结节术后病理为甲状腺乳头状癌, 1个术后病理为结节性甲状腺肿。在44个检测到BRAF V600E突变结节中,FNAB诊断恶性28个,良性6个,无法确定性质10个。在20个未检测到BRAF V600E突变结节中,FNAB诊断恶性5个,良性3,无法确定性质12个,术后病理14个甲状腺乳头状癌,4个结节性甲状腺肿,1个亚急性甲状腺炎,1个甲状腺腺瘤。共57个甲状腺乳头状癌中,检查到BRAF V600E基因突变有43个,突变率为75.4%。与手术病理金标准比较,FNAB判断甲状腺结节良恶性的灵敏度、特异度、阳性预测值、阴性预测值、正确率分别是78.9%、85.7%、97.8%、33.3%、79.7%;BRAF V600E基因检测判断甲状腺结节良恶性的灵敏度、特异度、阳性预测值、阴性预测值、正确率分别是75.4%、85.7%、97.7%、30.0%、76.6%;FNAB联合BRAF V600E基因检测判断甲状腺结节良恶性的灵敏度、特异度、阳性预测值、阴性预测值、正确率分别是94.7%、71.4%、96.4%、62.5%、92.2%。采用McNemar配对资料χ2检验比较FNAB、FNAB联合BRAF基因检测两种诊断方法的差别,P<0.001,两者差异有显著统计学意义。结论 对FNAB无法明确性质的甲状腺结节,辅助联合BRAF V600E基因检测,可以提高甲状腺结节良恶性诊断的准确性。

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备注/Memo

备注/Memo:
(收稿日期:2016-09-13)
(本文编辑:俞瑞纲)
更新日期/Last Update: 2017-07-12