[1]陆发承,王家平,邢艺苑,等.肾动脉移植骨髓间充质干细胞治疗大鼠慢性肾病结果分析 [J].介入放射学杂志,2017,(04):351-354.
 LU Facheng,WANG Jiaping,XING Yiyuan,et al.Bone marrow mesenchymal stem cells transplantation via renal artery for the treatment of chronic nephropathy in rats: analysis of experimental results[J].journal interventional radiology,2017,(04):351-354.
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肾动脉移植骨髓间充质干细胞治疗大鼠慢性肾病结果分析



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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2017年04期
页码:
351-354
栏目:
实验研究
出版日期:
2017-04-25

文章信息/Info

Title:
Bone marrow mesenchymal stem cells transplantation via renal artery for the treatment of chronic nephropathy in rats: analysis of experimental results
作者:
陆发承 王家平 邢艺苑 万珊杉 韩 磊
Author(s):
LU Facheng WANG Jiaping XING Yiyuan WAN Shanshan HAN Lei
Department of Radiology, Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650101, China
关键词:
【关键词】 骨髓间充质干细胞 干细胞移植 肾动脉 肾病
文献标志码:
A
摘要:
【摘要】 目的 分析和评价经肾动脉途径移植骨髓间充质干细胞(BMSC)对慢性阿霉素肾病模型大鼠的治疗结果。方法 采用50只雄性Sprague- Dawley大鼠作为实验动物。其中2只 12周龄大鼠用于BMSC分离培养;12只作为空白对照组(N组),36只经尾静脉注入阿霉素制作慢性肾病大鼠模型,并随机分为慢性肾病对照组(C组)、经肾动脉移植BMSC组(A组)和经尾静脉移植BMSC组(V组),每组12只。N组经尾静脉注入等量0.9%氯化钠溶液。结果 A组、V组、C组在各观察时点血尿素氮、血肌酐、24 h尿蛋白、24 h尿微量蛋白水平均明显高于N组(P<0.01)。移植后1、2周A组24 h尿微量蛋白均低于C组(P<0.01),且血肌酐均较C组和V组低(P<0.01);移植后1周A组24 h尿蛋白、24 h尿微量蛋白均明显低于V组(P<0.01),但2周时与V组差异无统计学意义。结论 经肾动脉途径移植BMSC可提高细胞归巢效率,并提高对损伤组织的修复作用。

参考文献/References:

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备注/Memo

备注/Memo:
(收稿日期:2016-07-07)
(本文编辑:边 佶)
更新日期/Last Update: 2017-04-11