[1]牛立志,曾健滢,张怡湜,等.不可逆电穿孔消融治疗胰腺癌的安全性及近期疗效观察[J].介入放射学杂志,2016,(03):225-230.
　NIU Li- zhi,ZENG Jian- ying,ZHANG Yi- shi,et al.Irreversible electroporation ablation therapy for pancreatic adenocarcinoma： observation of its safety and short- term effect[J].journal interventional radiology,2016,(03):225-230.
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不可逆电穿孔消融治疗胰腺癌的安全性及近期疗效观察 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2016年03期
页码:
225-230
栏目:
非血管介入
出版日期:
2016-03-25

文章信息/Info

Title:
Irreversible electroporation ablation therapy for pancreatic adenocarcinoma： observation of its safety and short- term effect
作者:
牛立志;  曾健滢;  张怡湜;  梁 冰;  周 亮;  方 刚;  李书英;  李忠海;  李蓉蓉;  陈继冰;  李朝龙;  王建南;  李海波;  穆 峰;  徐克成
Author(s):
NIU Li- zhi;  ZENG Jian- ying;  ZHANG Yi- shi;  LIANG Bing;  ZHOU Liang;  FANG Gang;  LI Shu- ying;  LI Zhong- hai;  LI Rong- rong;  CHEN Ji- bing;  LI Chao- long;  WANG Jian- nan;  LI Hai- bo;  MU Feng;  XU Ke- cheng
Fuda Cancer Hospital， School of Medicine， Ji’nan University， Guangzhou， Guangdong Province 510665， China
关键词:
【关键词】 不可逆电穿孔;  胰腺癌;  近期疗效
文献标志码:
A
摘要:
【摘要】 目的 使用不可逆电穿孔（IRE）消融技术治疗不可手术切除性局部进展胰腺癌，观察该技术治疗胰腺癌的安全性和疗效。方法 前瞻性观察IRE消融术后30 d内不良反应并按照mRECIST标准评价术后（30±7） d客观疗效。结果 共12例患者接受治疗，IRE手术均顺利完成，术后30 d内不良反应有穿刺点疼痛（5例，占41.7%）、恶心呕吐（3例，占25.0%）、咳嗽、术后低血糖、低钾血症、胃壁和十二指肠水肿各2例，占16.7%、胃瀦留、发热及胸闷气促各1例，8.3%，经对症治疗后好转，未见治疗相关性大出血、胆漏或胰漏等严重并发症。术后24 h、7 d血液淀粉酶与术前相比，差异无统计学意义（P>0.05）。术后（30±7） d评价效果：完全缓解（CR）1例，部分缓解（PR）9例，稳定（SD）2例，肿瘤缓解率（CR+PR）为83.3%。结论 IRE消融治疗不可手术切除性胰腺癌，不良反应轻，安全性高，近期疗效显著。远期疗效有待进一步观察。

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备注/Memo

备注/Memo:
（收稿日期：２０１5-０9-3０）
（本文编辑：俞瑞纲）
更新日期/Last Update: 2016-03-22