[1]梁晓东,王子亮,李天晓,等.替罗非班在颅内破裂动脉瘤介入治疗术中预防性应用研究[J].介入放射学杂志,2015,(12):1034-1038.
 LIANG Xiao- dong,WANG Zi- liang,LI Tian- xiao,et al.The prophylactic application of tirofiban in interventional treatment for ruptured intracranial aneurysms: a clinical research[J].journal interventional radiology,2015,(12):1034-1038.
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替罗非班在颅内破裂动脉瘤介入治疗术中预防性应用研究 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年12期
页码:
1034-1038
栏目:
神经介入
出版日期:
2015-12-25

文章信息/Info

Title:
The prophylactic application of tirofiban in interventional treatment for ruptured intracranial aneurysms: a clinical research
作者:
梁晓东 王子亮 李天晓 贺迎坤 赵同源 许岗勤 汪勇锋 周腾飞 邵秋季
Author(s):
LIANG Xiao- dong WANG Zi- liang LI Tian- xiao HE Ying- kun ZHAO Tong- yuan XU Gang- qin WANG Yong- feng ZHOU Teng- fei SHAO Qiu- ji
Interventional Therapy Center, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, Henan Province 450003, China
关键词:
【关键词】 替罗非班 颅内动脉瘤 破裂 预防 抗血小板 出血 血栓栓塞
文献标志码:
A
摘要:
【摘要】 目的 探讨替罗非班在颅内破裂动脉瘤介入栓塞治疗术中应用的安全性和有效性。方法 回顾性分析2012年1月至2014年11月因颅内动脉瘤破裂在河南省人民医院接受介入栓塞治疗且术中应用替罗非班患者的临床资料。替罗非班应用方案:支架释放前或单纯弹簧圈栓塞完成时经静脉给予负荷剂量(8.0 μg/kg,3 min内推注完毕),继而维持剂量(0.1 μg/kg?min)至术后24 h,撤药前2 h给予负荷剂量抗血小板口服药物替换。观察分析替罗非班应用期间发生的颅内出血和血栓栓塞事件。结果 入组208例患者中支架辅助栓塞166例(79.81%),单纯弹簧圈栓塞42例(20.19%)。替罗非班相关颅内出血4例(1.92%,均发生在支架辅助栓塞队列),其中术中3例(1.44%),术后1例(0.48%);血栓栓塞事件6例(2.88%,支架辅助栓塞5例,单纯弹簧圈栓塞1例),其中术中支架内血栓形成1例(0.48%),术后维持用药期间血栓栓塞相关症状5例(2.40%)。结论 经静脉负荷剂量继而维持剂量替罗非班在颅内破裂动脉瘤介入栓塞治疗术中预防性应用是安全、有效的。

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备注/Memo

备注/Memo:
(收稿日期:2015-05-22)
(本文编辑:边 佶)
更新日期/Last Update: 2015-12-24