[1]李 鑫,王黎洲,李 兴,等.糖尿病患者颈动脉支架植入后认知功能与S-100 B蛋白水平探讨[J].介入放射学杂志,2015,(08):653-657.
　LI Xin,WANG Li- zhou,LI Xing,et al.Investigation of cognitive function and serum S- 100 B protein level in diabetic patients after receiving carotid artery stent implantation[J].journal interventional radiology,2015,(08):653-657.
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糖尿病患者颈动脉支架植入后认知功能与S-100 B蛋白水平探讨 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年08期
页码:
653-657
栏目:
神经介入
出版日期:
2015-08-25

文章信息/Info

Title:
Investigation of cognitive function and serum S- 100 B protein level in diabetic patients after receiving carotid artery stent implantation
作者:
李 鑫;  王黎洲;  李 兴;  宋 杰;  蒋天鹏;  周 石
Author(s):
LI Xin;  WANG Li- zhou;  LI Xing;  SONG Jie;  JIANG Tian- peng;  ZHOU Shi
Department of Radiology， Affiliated Hospital of Guiyang Medical College， Guiyang， Guizhou Province 550004， China
关键词:
【关键词】 S- 100 B蛋白;  颈动脉狭窄;  颈动脉支架植入术;  认知功能;  糖尿病
文献标志码:
A
摘要:
【摘要】 目的 探讨严重颈动脉狭窄伴糖尿病和不伴糖尿病患者经颈动脉支架成形术（CAS）治疗后认知功能改善是否存在差异，认知功能改善与血清S- 100 B蛋白水平的关系。方法 随机将128例重度颈内动脉狭窄患者纳入本研究，分为伴糖尿病组（n=52）和不伴糖尿病组（n=76），两组患者术前临床一般情况及认知功能情况无显著差异。对患者CAS术前及术后3个月血清S- 100 B蛋白水平及简易智能精神状态检查量表（MMSE）、Montreal认知评估量表（MoCA）、Alzheimer评定量表认知分表（ADAS- Cog）、画钟测验（CDT）等评分数据进行分析比较。结果 不伴糖尿病组CAS术后血清S- 100 B蛋白水平（0.10±0.04） ng/ml较术前（0.11±0.04） ng/ml明显降低（P=0.000），术后3个月认知功能相关MMSE（24.8± 2.2对25.2±2.1）、MoCA（25.6±2.0对26.1±1.9）、ADAS- Cog（6.5±1.3 对6.1±1.3）、CDT（3.3±0.7对3.5±0.7）评分均较术前有明显改善（P＜0.01）；伴糖尿病组CAS术后血清S-100 B蛋白水平及MMSE、MoCA、ADAS- Cog、CDT评分较术前无明显变化（P=0.159）。血清S- 100 B蛋白下降水平与MMSE（r=0.38，P＜0.01）、MoCA（r=0.39，P＜0.01）评分增加和ADAS- Cog（r=0.19，P＜0.05）评分递减呈正相关。结论 CAS术后颈动脉狭窄伴认知功能障碍患者认知功能恢复存在个体差异，认知功能改善程度与血清S- 100 B蛋白水平降低相关。颈动脉狭窄伴糖尿病患者认知功能障碍无明显改善，且S-100 B蛋白水平无明显变化。伴和不伴糖尿病患者认知功能障碍的机制可能不同，单纯改善缺血情况不能改善伴糖尿病患者认知功能障碍。

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备注/Memo

备注/Memo:
（收稿日期：２０１5-０2-21）
（本文编辑：边 佶）
更新日期/Last Update: 2015-08-23