[1]丁以锟,吕维富,周春泽,等. 术后预防性肝动脉化疗栓塞对肝癌患者生存的影响及预后相关因素分析[J].介入放射学杂志,2014,(04):299-302.
 DING Yi-kun,LV Wei-fu,ZHOU Chun-ze,et al. The influence of postoperative TACE on the survival time and prognosis in hepatocellular carcinoma patients after liver resection[J].journal interventional radiology,2014,(04):299-302.
点击复制

 

术后预防性肝动脉化疗栓塞对肝癌患者生存的影响及预后相关因素分析

()

PDF下载中关闭

分享到:

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2014年04期
页码:
299-302
栏目:
肿瘤介入
出版日期:
2014-04-29

文章信息/Info

Title:
 The influence of postoperative TACE on the survival time and prognosis in hepatocellular carcinoma patients after liver resection
作者:
 

丁以锟 吕维富 周春泽 鲁 东 唐文静

Author(s):
 DING Yi-kun LV Wei-fu ZHOU Chun-ze LU Dong TANG Wen-jing.
 

Department of Interventional Radiology, Affiliated Anhui Provincial Hospital, Anhui Medical University, Hefei, Anhui Province 230001, China

关键词:
 

【关键词】 肝癌术后 生存 预防 肝动脉化疗栓塞 预后

文献标志码:
A
摘要:
 【摘要】 目的 探讨术后行预防性肝动脉化疗栓塞(TACE)对肝细胞癌(HCC)患者生存的影响及预后相关因素分析。方法 回顾性分析我院2008年1月—2012年11月确诊肝癌行根治性肝切除且术后行TACE治疗的92例患者的临床和随访资料。将术后2个月内影像学检查未发现病灶行预防性TACE者为预防组;按期随访直至复发再行TACE者为对照组,用Kaplan?蛳 Meier法比较两组生存差异,并采用COX回归分析影响肝癌术后患者生存及预后的相关因素。结果 92例患者中预防组为38例,对照组54例,两组患者基线资料比较差异无统计学意义。预防组1、2、3年生存率分别为85.1%、56.8%、56.8%,中位生存时间为39个月;对照组分别为65.2%、43.4%、30.4%,中位生存时间为21个月。预防组和对照组累计生存率差异有统计学意义(P = 0.021)。在单因素分析中门脉癌栓、肿瘤直径、腹水、凝血酶原时间及是否行预防性TACE是可能影响预后的相关因素。多因素分析中,是否行预防性TACE及肿瘤直径是显著影响预后的独立相关因素。结论 肝癌患者术后行预防性TACE可明显提高患者的生存率,另外肿瘤直径也是显著影响预后的独立相关因素。

参考文献/References:

 

[1] Tanaka S, Noguchi N, Ochiai T, et al. Outcomes and recurrence of initially resectable hepatocellular carcinoma meeting Milan criteria: Rationale for partial hepatectomy as first strategy[J]. J Am Coll Surg, 2007, 204: 1 ?蛳 6.

[2] Xi T, Yan ZL, Wang K, et al. Role of post?蛳 operative transcatheter arterial chemoembolization in hepatocellular carcinoma with different pathological characteristics[J]. Zhonghua Wai Ke Za Zhi, 2007, 45: 587 ?蛳 590.

[3] Lau WY, Lai EC, Leung TW, et al. Adjuvant intra?蛳 arterial iodine?蛳 131?蛳 labeled lipiodol for resectable hepatocellular carcinoma: a prospective randomized trial?蛳 update on 5?蛳 year and 10?蛳 year survival[J]. Ann Surg, 2008, 247: 43 ?蛳 48.

[4] 刘鹏飞, 刘荣华, 徐 荷, 等. 原发性肝癌术后预防性TACE的意义(附433例病例随访)[J]. 中华肝胆外科杂志, 2005, 11: 81 ?蛳 82.

[5] Poon RT, Fan ST, Tsang HF, et al. Locoregional therapies for hepatocellular carcinoma: a critical review form the surgeons perspective[J]. Ann Surg, 2002, 235: 466 ?蛳 486.

[6] Mathurin P, Raynard B, Dharancy S, et al. Meta?蛳 analysis: evaluation of adjuvant therapy after curative liver resection for hepatocellular carcinoma[J]. Aliment Pharmacol Ther, 2003, 17: 1247 ?蛳 1261.

[7] 徐国斌, 易广新, 熊 斌, 等. 原发性肝癌术后早期肝内复发转移36例的介入治疗[J]. 介入放射学杂志, 2013, 22: 325 ?蛳 328.

[8] Portolani N, Coniglio A, Ghidoni S, et al. Early and late recurrence after liver resection for hepatocellular carcinoma: prognostic and therapeutic implications[J]. Ann Surg, 2006, 243: 229 ?蛳 235.

[9] Mehrabi A, Mood ZA, Mood Z, et al. Mesohepatectomy as an option for the treatment of central liver tumors[J]. J Am Coll Surg, 2008, 207: 499 ?蛳 509.

[10] Giannelli G, Pierri F, Trerotoli P, et al. Occurrence of portal vein tumor thrombus in hepatocellular carcinoma affects prognosis and survival. A retrospective clinical study of 150 cases[J]. Hepatol Res, 2002, 24: 50.

[11] 樊 嘉, 汤钊猷, 吴志全, 等. 门静脉微癌栓和肉眼癌栓对肝癌患者术后生存的影响[J]. 中华外科杂志, 2005, 43: 433 ?蛳 435.

相似文献/References:

[1]张 琳,黄学全,王健,等.自主研发电化学治疗同轴电极与传统针式电极电解效应的对比研究[J].介入放射学杂志,2012,(02):148.
 ZHANG Lin,HUANG Xue-quan,WANG Jian,et al.The electrolytic effect in electrochemotherapy: a comparative study between self-prepared coaxial electrode and conventional needle electrode[J].journal interventional radiology,2012,(04):148.
[2]赵 玮,王伟中,陈莹,等.耳部动静脉畸形供血动脉的血管造影研究[J].介入放射学杂志,2012,(02):103.
 ZHAO Wei,WANG Wei-zhong,CHEN Ying,et al.Angiographic findings of the feeding arteries of auricular arteriovenous malformations[J].journal interventional radiology,2012,(04):103.
[3]邹俊民,龙世娟,张振明. 改良髂内动脉化疗联合放疗治疗Ⅲ~Ⅳa期 子宫颈癌32例[J].介入放射学杂志,2012,(02):123.
 ZOU Jun-min,LONG Shi-Juan,ZHANG Zheng-ming..Improved internal iliac artery chemotherapy combined with radiotherapy for the treatment of stage Ⅲ-Ⅳa cervical cancers[J].journal interventional radiology,2012,(04):123.
[4]王昌明,李 选,宋世兵,等.肝门部胆道引流管折叠技术在肝移植后胆道非吻合口狭窄治疗中的应用[J].介入放射学杂志,2012,(02):136.
 WANG Chang-ming,LI Xuan,SONG Shi-bing,et al.The application of biliary catheter folding technique in the treatment of hilar nonanastomotic biliary strictures after orthotopic liver transplantation[J].journal interventional radiology,2012,(04):136.
[5]赵玉峰,孙玉琴,韩晓静,等. 输卵管介入再通术后受孕时机的研究[J].介入放射学杂志,2012,(02):158.
 ZHAO Yu-feng,SUN Yu-qin,HAN Xiao-jing,et al.The optimal time for conception after fallopian tube recanalization therapy[J].journal interventional radiology,2012,(04):158.
[6]含 笑,曹建民,史东宏,等.吉西他滨、顺铂动静脉联合化疗治疗晚期非小细胞肺癌的近期疗效分析[J].介入放射学杂志,2012,(02):119.
 HAN Xiao,CAO Jian-min,SHI Dong-hong,et al.Bronchial artery infusion of Gemcitabine and Cisplatin combined with systemic chemotherapy for advanced non-small cell lung cancer: its short-term efficacy[J].journal interventional radiology,2012,(04):119.
[7]姚雪松,李 槐.不可手术切除的肝细胞癌的疗效评价标准——改良RECIST标准更可靠[J].介入放射学杂志,2012,(03):177.
 . Therapeutic evaluation criterion of inoperable hepatocellular carcinomas: modified RECIST as a more reliable standard[J].journal interventional radiology,2012,(04):177.
[8]齐 立,李慎茂,俸军林,等. 动脉溶栓与机械碎栓联合动脉溶栓的对比分析[J].介入放射学杂志,2012,(03):180.
 ,,et al. Comparison of the therapeutic efficacy between simple arterial thrombolysis and mechanical thrombectomy combined with arterial thrombolysis for acute cerebral infarction at its ultraearly stage[J].journal interventional radiology,2012,(04):180.
[9]石 潆,赵 卫,沈 进,等.脑动静脉畸形栓塞治疗术并发颅内出血的原因及处理[J].介入放射学杂志,2012,(03):185.
 ,,et al.Intracranial hemorrhage due to embolization therapy for cerebral arteriovenous malformation: its causes and management [J].journal interventional radiology,2012,(04):185.
[10]周 慷,李晓光,金征宇,等.清宫术前子宫动脉化疗栓塞术治疗瘢痕妊娠的疗效分析[J].介入放射学杂志,2012,(03):190.
 ,,et al.Therapeutic analysis of bilateral uterine artery chemoembolization performed before uterine dilation and curettage for cesarean scar pregnancy [J].journal interventional radiology,2012,(04):190.

备注/Memo

备注/Memo:
 收稿日期:2013-09-13
更新日期/Last Update: