[1]赵苏鸣,戴瑞茹,黄 健,等. 犬急性骨水泥肺栓塞的实验研究[J].介入放射学杂志,2012,(01):55-60.
 ZHAO Su-ming,DAO Rui-ru,HUANG Jian,et al. Acute pulmonary embolism caused by PMMA: an experimental study in canines[J].journal interventional radiology,2012,(01):55-60.
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 犬急性骨水泥肺栓塞的实验研究 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2012年01期
页码:
55-60
栏目:
实验研究
出版日期:
2012-01-30

文章信息/Info

Title:
 Acute pulmonary embolism caused by PMMA: an experimental study in canines
作者:
 赵苏鸣戴瑞茹黄 健赵 辉吴献华
226001 江苏省南通 南通大学附属医院介入科
Author(s):
ZHAO Su-ming DAO Rui-ru HUANG Jian ZHAO Hui WU Xian-hua.
 Department of Intervention Radiology, Affiliated Hospital of Nantong University, Nantong 226001, China
关键词:
 【关键词】 椎体成形术 骨水泥 肺栓塞 聚甲基丙稀酸甲酯
文献标志码:
A
摘要:
【摘要】 目的 通过股静脉注入骨水泥建立犬急性肺栓塞模型,探讨一定剂量范围内不同量骨水泥肺栓塞引起的生理病理变化间的差异。方法 18只成年家犬随机分成A、B、C 3组,每组6只,麻醉后行胸部CT平扫,穿刺右股静脉。左股动脉并置入血管鞘,经静脉鞘注入聚甲基丙烯酸甲酯(PMMA)A组0.5 ml,B组1 ml,C组2 ml。于注入PMMA前和注入后即刻、30 min及1 h分别检测血气分析、平均肺动脉压;于注入PMMA前、后5 min行肺动脉造影。术后1h行胸部CT平扫 + 增强。术后2 h将犬处死,开胸解剖观察大体形态后,沿肺动脉分支方向随机取肺组织3块进行病理学检查。结果 18只实验犬经股静脉注入PMMA操作均成功,经CT及病理证实均成功建立急性骨水泥肺栓塞模型。各组实验犬动脉血氧分压、二氧化碳分压在骨水泥注入前后差异均无统计学意义(P > 0.05)。仅C组骨水泥注入后即刻平均肺动脉压为(24.12 ± 1.74)mmHg,注入后30 min为(23.84 ± 1.25)mmHg,注入后1 h为(24.17 ± 1.63)mmHg,均较注射前的(16.47 ± 0.55)mmHg差异有统计学意义(P < 0.05)。A组 、B组平均肺动脉压在骨水泥注入前后差异均无统计学意义(P > 0.05)。各组实验犬术后胸部CT平扫均可见两肺高密度影,下肺多见,C 组尤为明显。部分实验犬平扫见条索状阴影及肺不张征象。C组部分实验犬胸部增强CT可见肺动脉小分支内部分充盈缺损。肺动脉造影仅C组部分实验犬出现肺内部分细小血管减少,血管纹理稀疏,未见肺动脉主干及分支的充盈缺损。病理学检查均发现肺动脉分支存在骨水泥栓子,未见继发血栓形成。结论 ≤ 2 ml的骨水泥致急性肺栓塞的严重程度与注入骨水泥剂量没有相关性。在心肺功能正常情况下,≤ 2 ml的急性骨水泥肺栓塞不会引起明显的呼吸功能障碍。

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备注/Memo

备注/Memo:
 (收稿日期:2011-01-15)
更新日期/Last Update: