[1]许永华,符忠祥,杨利霞,等.MRI导航和温度监控下高强度聚焦超声治疗子宫肌瘤[J].介入放射学杂志,2010,(11):869-873.
 XU Yong-hua,FU Zhon-gxiang,YANG Li-xia,et al.MR-guided high intensity focused ultrasound thermoablation under temperature mapping monitoring for the treatment of uterine fibroids[J].journal interventional radiology,2010,(11):869-873.
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MRI导航和温度监控下高强度聚焦超声治疗子宫肌瘤()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2010年11期
页码:
869-873
栏目:
非血管介入
出版日期:
2010-11-25

文章信息/Info

Title:
MR-guided high intensity focused ultrasound thermoablation under temperature mapping monitoring for the treatment of uterine fibroids
作者:
许永华符忠祥杨利霞陈文直刘映江叶方伟王智彪
作者单位: 200031 上海市徐汇区中心医院医学影像科;重庆医科大学生物医学工程系
Author(s):
XU Yong-hua FU Zhon-gxiang YANG Li-xia CHEN Wen-zhi LIU Ying-jiang YE Fang-wei WANG Zhi-biao.
Department of Medical Imaging, Central Hospital of Xuhui District, Shanghai 200031, China
关键词:
高强度聚焦超声 子宫肌瘤 磁共振
分类号:
R737.33
文献标志码:
A
摘要:
目的评价高强度聚焦超声(HIFU)在MR导航定位和靶区焦域温度监控下治疗子宫肌瘤的可行性和疗效。方法采用西门子1.5TAvantoTIMMR导航和温度监控JMHIFU进行HIFU治疗52例子宫肌瘤共61个肌瘤。肌瘤大小(6.1±2.1)cm,其中浆膜下10枚、肌壁间46枚和黏膜下5枚。治疗前、后采用增强扫描MRI检查,测量肌瘤体积、消融坏死区域大小占肌瘤体积的比率,并记录治疗时间和超声释放剂量。治疗后3个月MRI检查观察肌瘤的缩小情况;同时观察和评估其并发症及不良反应事件发生,并对治疗前后患者症状变化进行评分。结果MR导航HIFU(MRgHIFU)治疗前和治疗后3个月肌瘤平均体积分别为(113.3±87.7)cm3和(58.1±45.0)cm3,肌瘤体积平均缩小(48.7±16.4)%(P<0.05);每个肌瘤被消融区域占整个肌瘤体积平均为(78.8±18.8)%(51%~100%);聚焦超声治疗时间(19.8±8.8)min,治疗所用的超声热剂量为(7.1±6.7)焦耳/mm3。患者症状平均总分治疗前、后从(24.7±4.8)下降至(16.7±3.2)分(P<0.05),除1例术中出现腹壁皮下轻度烫伤,余无并发症及不良反应事件。结论MRgHIFU治疗子宫肌瘤是一种可行、安全、有效的无创治疗方法,而且单次热消融可达到肌瘤大部分甚至完全凝固性坏死,并使其短期内缩小的治疗效果。

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备注/Memo

备注/Memo:
收稿日期:20100903
更新日期/Last Update: 2010-11-25