[1]费 伦,郭金友,郑家平,等.CT引导下放射性粒子125I植入治疗骨转移瘤患者的临床研究[J].介入放射学杂志,2020,29(09):930-933.
 FEI Lun,GUO Jinyou,ZHENG Jiaping,et al.CT-guided 125I particles implantation for the treatment of patients with bone metastases: a clinical study[J].journal interventional radiology,2020,29(09):930-933.
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CT引导下放射性粒子125I植入治疗骨转移瘤患者的临床研究()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
29
期数:
2020年09
页码:
930-933
栏目:
临床研究
出版日期:
2020-09-25

文章信息/Info

Title:
CT-guided 125I particles implantation for the treatment of patients with bone metastases: a clinical study
作者:
费 伦 郭金友 郑家平 梅伟东 韩瑞雪 沈剑英
Author(s):
FEI Lun GUO Jinyou ZHENG Jiaping MEI Weidong HAN Ruixue SHEN Jianying.
Department of Oncology, Yuhuan Municipal Second People’s Hospital, Yuhuan, Zhejiang Province 317605, China
关键词:
【关键词】 125I放射性粒子 骨转移瘤 癌痛 KPS NRS
文献标志码:
A
摘要:
【摘要】 目的 探讨125I粒子植入治疗骨转移瘤患者的有效性和安全性。 方法 将骨转移瘤患者54例分为两组,其中行125I粒子植入的30例患者为治疗组,植入粒子总数1 581粒,平均每例植入(52±6)粒,另24例患者行药物治疗为对照组,比较两组的疼痛治疗有效率(NRS评分)、功能状态改善有效率(KPS评分)、以及病灶治疗疗效的差异,比较两组治疗前后的血清碱性磷酸酶(ALP)变化,不良反应和并发症的发生情况。 结果 治疗组的功能状态改善率为60%,高于对照组的29.2%;治疗组的镇痛显效率为36.2%,高于对照组的4.2%;病灶治疗的临床有效率为93.3%,高于对照组的8.3%,差异均有统计学意义(均P<0.05)。治疗组治疗后血清ALP水平降低,差异有统计学意义(P<0.05)。无严重不良反应和并发症发生。结论 125I粒子植入能有效缓解骨转移瘤引起的疼痛,提高生活质量,是一种安全、有效的治疗方法。

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备注/Memo

备注/Memo:
(收稿日期:2019-07-08)
(本文编辑:俞瑞纲)
更新日期/Last Update: 2020-09-15